Search results for "TTV"

Collaborative Management in Norwegian Municipalities: Do Middle Managers Make a Difference?

2022

Norway is an example of the Nordic model in which the local level is of fundamental importance. However, the municipalities are relatively small and increasingly subject to decentralisation of their activities. To compensate for scale disadvantages, a mixture of collaborative activities is pursued in order to build system capacity. Paradoxically, little is known about collaboration among key stakeholders. This article makes a contribution to reducing this knowledge gap by focusing on mid-level managers and municipal departments. This research is empirically underpinned by a cross sectional survey of middle managers in 64 municipalities in Norway (N = 1354) and presents, for the first time, …

Comparative evaluation of molecular methods for the quantitative measure of torquetenovirus (TTV) viremia, the new surrogate marker of immune compete…

2019

Background Torquetenovirus (TTV) viremia is emerging as a promising tool to assess functional immune competence, to predict posttransplant immune-related complications, and eventually to customize immunosuppression. Methods In this study, 327 blood samples were tested using two real-time PCR (rtPCR) assays both targeted to the untranslated region of the TTV genome. The first assay was an in-house rtPCR developed by our group, the second one was the recently marketed TTV R-GENE assay. Results In the validation study, the TTV R-GENE showed good performances in precision and reproducibility, and sensitivity as low as 12 TTV DNA copies/mL, like previously reported for the in-house rtPCR. The Bl…

Assessment of prevalence and load of torquetenovirus viraemia in a large cohort of healthy blood donors.

2020

OBJECTIVES: Torquetenovirus (TTV) is an emerging marker of functional immune competence with the potential to predict transplant-related adverse events. A large-scale epidemiological study was performed to understand how basal values vary in healthy individuals according to age and gender.; METHODS: We tested plasma from 1017 healthy blood donors aged 18-69years. The presence and load of TTV were determined by a real-time PCR assay. A sub-cohort of 384 donors was tested for anti-cytomegalovirus IgG antibodies, and 100 participants were also tested for TTV viraemia on a paired whole blood sample.; RESULTS: The overall prevalence of TTV was 65% (657/1017) with a mean (±SD) growth of 5±4% ever…

Coping with pandemics using social network sites: A psychological detachment perspective to COVID-19 stressors

2022

Prior research has often portrayed information technology (IT) as a stressor. In this paper, we propose and demonstrate that IT can also be an effective means of coping with life stressors, including those induced by pandemics such as COVID-19. We thus deviate from the common IT-as-a-stressor perspective and adopt an IT-as-a-coping-mechanism viewpoint. To this end, we apply the stressor-detachment model from organisational psychology to the use of social network sites (SNSs) in coping with stressors wrought by the COVID-19 pandemic. We examine psychological well-being as our dependant variable and introduce psychological detachment through SNS use as a mediator and moderator of the associat…

Zinātņu vēsture un muzejniecība (Latvijas Universitātes Raksti, 809. sēj.)

2015

Dynamics of Torque Teno virus plasma DNAemia in allogeneic stem cell transplant recipients

2017

Abstract Background Torque Teno virus (TTV) plasma DNA load directly correlate with the level of immunosuppresion in different clinical settings. It is uncertain whether this may be the case in allogeneic hematopoietic stem cell transplant recipients (allo-HSCT). Objectives We characterized the dynamics of TTV DNAemia in patients undergoing T-cell replete allo-SCT. Study design Retrospective single-center observational study including 72 allo-HSCT patients. Plasma TTV DNA loads were quantified before initiating the conditioning regimen and at different time-points after transplant by real-time PCR. White blood cells (WBC) and absolute lymphocyte counts (ALC) were measured by flow cytometry.…

Early Post-Transplant Torquetenovirus Viremia Predicts Cytomegalovirus Reactivations In Solid Organ Transplant Recipients.

2018

AbstractMonitoring the human virome has been recently suggested as a promising and novel area of research for identifying new biomarkers which would help physicians in the management of transplant patients. Imbalance of the immune system in transplant recipients has a significant impact on replication of Torquetenovirus (TTV), the most representative and abundant virus of human virome. TTV kinetic was studied by real-time PCR in 280 liver or kidney transplant recipients who underwent different drug regimens to maintain immunosuppression. During one-year post-transplant follow-up, TTV viremia fluctuated irrespective of transplanted organ type but consistent with the immunosuppression regimen…

Kinetics of torque teno virus DNA load in saliva and plasma following allogeneic hematopoietic stem cell transplantation

2018

Plasma torque teno virus (TTV) DNA load directly correlates with the degree of T-cell immune reconstitution early after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Here, the kinetics of oral TTV DNA shedding was examined to assess whether quantitation of TTV DNA load in saliva may either replace or complement that in plasma for predicting lymphocyte (ALC) reconstitution after engraftment. This prospective observational study enrolled 38 nonconsecutive allo-HSCT recipients. Saliva and plasma specimens were collected at baseline (pretransplant) and at around days +30, +50, and +90 after allo-HSCT. TTV DNA was quantitated in both specimen types by real-time PCR. ALCs were m…

Mitt liv - bare "mitt"? : konsekvenser av selvmord for foreldre når barn tar sitt eget liv

2018

Masteroppgave Sosiologi og sosialt arbeid ME522 - Universitetet i Agder 2018 Hovedformålet med denne studien er å bidra med mer kunnskap, for å forbedre faglig omsorg for foreldre som har mistet et barn i selvmord ved å utforske noen områder av interesse. I denne oppgaven bruker jeg et kvalitativt design og strukturert og åpent intervju i form av spørreskjema som fremgangsmåte for å få mer kunnskap om etterlatte ved selvmord. Oppgavens viktigste empiri er kvalitative intervjuer med mennesker som har opplevd å være etterlatt etter selvmord. Jeg har intervjuet ni foreldre som alle har mistet et barn i selvmord, seks kvinner og tre menn. De er intervjuet i forhold til arbeidssituasjonen, offen…

Brukerens erfaring og opplevelse av gjeninnleggelse i psykiatrisk døgnavdeling : "... de fleste mennesker har jo nok med sine egne familier, så det e…

2014

There has been a shifting change that has been in process over the years. From a hospital oriented based care offer in psyciatric health care, to a more desentralised direction where the care is oritented through community-based service. The idea is that everyone is to receive individual and costumised help in the community where they live. One wishes that every being gets the help they need in the community so that they can have the opportunity to be integrated and live as a part of the community. The number of bedposts in psychiatric hospitals has decreased over the years, and the community-based services has increased the offer. At the same time it has been noticed that some people are r…