Search results for "TYR"

Kalmbergin kartasto R III : List 10

1855

Differential roles of PKCα and PKCɛ in controlling the gene expression of Nox4 in human endothelial cells

2007

NADPH oxidases are major sources of superoxide in the vascular wall. This study investigates the role of protein kinase C (PKC) in regulating gene expression of NADPH oxidases. Treatment of human umbilical vein endothelial cells (HUVEC) and HUVEC-derived EA.hy 926 endothelial cells with phorbol 12-myristate 13-acetate (PMA) or phorbol 12,13-dibutyrate led to a PKC-dependent biphasic expression of the gp91phox homolog Nox4. A downregulation of Nox4 was observed at 6 h and an upregulation at 48 h after phorbol ester treatment. The early Nox4 downregulation was associated with a reduced superoxide production, whereas the late Nox4 upregulation was accompanied by a clear enhancement of superoxi…

A GEOSITE TO BE SAVED: THE TYRRHENIAN FOSSIL DEPOSIT ON THE ISLAND OF USTICA

2014

During the 1960s, fossil beds characterized by a tropical-sea malacofauna were discovered by G. Ruggieri and G. Buccheri in the Island of Ustica, on the southern slope of Falconiera hill, 32 m asl. Thanks to the presence of Strombus bubonius and other Senegalese guests, the authors estimated that the molluscan fauna had lived around 125,000 years ago, during the Tyrrhenian stage. Recently on the initiative of the “Centro Studi e Documentazione Isola di Ustica”, a research has been initiated to verify the persistence of sand-layers mixed up with Tyrrhenian fossils, even though, in the last 50 years, that area has undergone great changes, because of earthworks which have sealed the deposit. T…

Ethical Considerations in Crowdfunding

2020

AbstractThe current chapter addresses ethical issues in crowdfunding practice from a multiple stakeholder perspective. It draws on ethical principles outlined in both classical and business-specific approaches. The discussion first presents classical approaches to ethical decision making. It then discusses whether crowdfunding presents an ethical solution or a source of ethical problems. Later, it suggests a framework presenting a classification of potential ethical dilemmas and pitfalls in crowdfunding practice, as well as potential means for addressing them. The discussion concludes with concrete implications for crowdfunding ethics research and practice.

Thermal conductivity measurement of insulating innovative building materials by hot plate and heat flow meter devices: A Round Robin Test

2019

Abstract The characterization of thermal insulation properties of construction materials represents a fundamental step on the building insulation assessment. In recent years innovative materials have been introduced in the market to fulfill the continuously growing requirements of energy saving and sustainability, and their performance is not so reliable and mature as it happens for traditional insulators. The work presents a Round Robin Test realised among six European laboratories hosting hot plates devices to measure the thermal conductivity of four different materials: aerogel, vacuum insulation panels, polystyrene and birch wood fibre insulation boards. After the definition of the comm…

Comparison on photo-initiators for the preparation of methacrylate monolithic columns for capillary electrochromatography.

2010

The synthesis of lauryl methacrylate monoliths for capillary electrochromatography by UV polymerization using several free-radical initiators (alpha,alpha'-azobisisobutyronitrile, 2,2-dimethoxy-2-phenylacetophenone, dibenzoyl peroxide (BPO) and lauroyl peroxide (LPO)) has been investigated. Using a 1,4-butanediol/1-propanol mixture as porogenic solvent, the influence of each initiator and its content on the morphological and electrochromatographical properties of beds was evaluated. Under their respective optimum content, satisfactory separations of a test mixture of PAHs with similar efficiencies (minimum plate heights of 8.0-12.7 microm obtained from Van Deemter plots) were achieved for t…

Anticancer therapy-induced vascular toxicity: VEGF inhibition and beyond

2017

Cardiotoxicity induced by chemotherapeutic agents and radiotherapy is a growing problem. In recent years, an increasing number of new drugs with targeted action have been designed. These molecules, such as monoclonal antibodies and tyrosine kinase inhibitors, can cause different type of toxicities compared to traditional chemotherapy. However, they can also cause cardiac complications such as heart failure, arterial hypertension, QT interval prolongation and arrhythmias. Currently, a field of intense research is the vascular toxicity induced by new biologic drugs, particularly those which inhibit vascular endothelial growth factor (VEGF) and its receptor (VEGF-R) and other tyrosine kinases.…

The impact of the receptor binding profiles of the vascular endothelial growth factors on their angiogenic features

2013

Abstract Background Vascular endothelial growth factors (VEGFs) are potential therapeutic agents for treatment of ischemic diseases. Their angiogenic effects are mainly mediated through VEGF receptor 2 (VEGFR2). Methods Receptor binding, signaling, and biological efficacy of several VEGFR2 ligands were compared to determine their characteristics regarding angiogenic activity and vascular permeability. Results Tested VEGFR2 ligands induced receptor tyrosine phosphorylation with different efficacy depending on their binding affinities. However, the tyrosine phosphorylation pattern and the activation of the major downstream signaling pathways were comparable. The maximal angiogenic effect stim…

Predicting efficacy and toxicity in the era of targeted therapy: focus on anti-EGFR and anti-VEGF molecules

2011

The treatment of solid malignancies includes various target drugs, such as monoclonal antibodies and tyrosine kinase inhibitors, which exert their effect alone or in combination with chemotherapy. The main part of these molecules have a target on proteins of EGFR and VEGF pathways. The particular toxicity profile and the financial impact, deriving from the application of these agents in cancer treatment, prompted a lot of researches to define predictive factors of their efficacy. Various biomarker were identified among the components of the targeted pathways. However just few studies allowed to identify specific factors to predict the toxicity of these drugs. In this review EGFR and VEGF-re…

Tyrosine Phosphorylation Modulates the Vascular Responses of Mesenteric Arteries from Human Colorectal Tumors

2013

The aim of this study was to analyze whether tyrosine phosphorylation in tumoral arteries may modulate their vascular response. To do this, mesenteric arteries supplying blood flow to colorectal tumors or to normal intestine were obtained during surgery and prepared for isometric tension recording in an organ bath. Increasing tyrosine phosphorylation with the phosphatase inhibitor, sodium orthovanadate produced arterial contraction which was lower in tumoral than in control arteries, whereas it reduced the contraction to noradrenaline in tumoral but not in control arteries and reduced the relaxation to bradykinin in control but not in tumoral arteries. Protein expression of VEGF-A and of th…