Search results for "TYR"

Modelling of the air purification from volatile organic compounds in a trickle-bed bioreactor

2016

Badano proces oczyszczania powietrza ze styrenu, substancji zaliczanej do grupy lotnych związków organicznych (LZO), prowadzony w pilotowym bioreaktorze strużkowym (TBB). Ponieważ najważniejszym etapem procesu oczyszczania powietrza z LZO w bioreaktorze strużkowym jest biologiczna reakcja jego rozkładu, zatem, projektując proces, należy przede wszystkim starannie wyselekcjonować mikroorganizmy efektywnie rozkładające usuwane z powietrza zanieczyszczenie, określić warunki najkorzystniejsze dla ich wzrostu oraz wyznaczyć kinetykę reakcji. W wyniku testów porównawczych wyselekcjonowano szczep efektywnie wykorzystujący styren jako jedyne źródło węgla i energii. Był to, pochodzący z kolekcji VTT…

Uusia ja vanhoja havaintoja Tyrvään Pyhän Olavin kirkosta, sen esineistöstä ja sen taiteesta

2021

Resistance training in patients with early inflammatory rheumatic diseases : special reference to neuromuscular function, bone mineral density and di…

1999

Immunoaffinity purification and characterization of mitochondrial membrane-bound D-3-hydroxybutyrate dehydrogenase from Jaculus orientalis.

2008

Abstract Background The interconversion of two important energy metabolites, 3-hydroxybutyrate and acetoacetate (the major ketone bodies), is catalyzed by D-3-hydroxybutyrate dehydrogenase (BDH1: EC 1.1.1.30), a NAD+-dependent enzyme. The eukaryotic enzyme is bound to the mitochondrial inner membrane and harbors a unique lecithin-dependent activity. Here, we report an advanced purification method of the mammalian BDH applied to the liver enzyme from jerboa (Jaculus orientalis), a hibernating rodent adapted to extreme diet and environmental conditions. Results Purifying BDH from jerboa liver overcomes its low specific activity in mitochondria for further biochemical characterization of the e…

Reductive modification of genetically encoded 3-nitrotyrosine sites in alpha synuclein expressed in E.coli

2019

Tyrosine nitration is a post-translational protein modification relevant to various pathophysiological processes. Chemical nitration procedures have been used to generate and study nitrated proteins, but these methods regularly lead to modifications at other amino acid residues. A novel strategy employs a genetic code modification that allows incorporation of 3-nitrotyrosine (3-NT) during ribosomal protein synthesis to generate a recombinant protein with defined 3-NT-sites, in the absence of other post-translational modifications. This approach was applied to study the generation and stability of the 3-NT moiety in recombinant proteins produced in E.coli. Nitrated alpha-synuclein (ASYN) was…

Artemisinin–Second Career as Anticancer Drug?

2015

Artemisinin represents a showcase example not only for the activity of medicinal herbs deriving from traditional chinese medicine, but for phytotherapy in general. Its isolation from Sweet Wormwood (qinhao, Artemisia annua L.) represents the starting point for an unprecedent success story in the treatment of malaria worldwide. Beyond the therapeutic value against Plasmodium parasites, it turned out in recent years that the bioactivity of artemisinin is not restricted to malaria. We and others found that this sesquiterpenoid also exerts profound anticancer activity in vitro and in vivo. Artemisinin-type drugs exert multi-factorial cellular and molecular actions in cancer cells. Ferrous iron …

Perinatal Western Diet Consumption Leads to Profound Plasticity and GABAergic Phenotype Changes within Hypothalamus and Reward Pathway from Birth to …

2017

This article is part of the Research Topic Early Life Origins of Obesity and Type 2 Diabetes.; International audience; Perinatal maternal consumption of energy dense food increases the risk of obesity in children. This is associated with an overconsumption of palatable food that is consumed for its hedonic property. The underlying mechanism that links perinatal maternal diet and offspring preference for fat is still poorly understood. In this study, we aim at studying the influence of maternal high-fat/high-sugar diet feeding [western diet (WD)] during gestation and lactation on the reward pathways controlling feeding in the rat offspring from birth to sexual maturity. We performed a longit…

Uddannelse som social kunstform?

2018

Malet med denne artikel er at undersoge nogle af de kunstneriske og paedagogiske dilemmaer, der kan opsta, nar man anvender praksisstyret aktionsforskning i udviklingen af egen undervisning i og gennem de kunstneriske fag ved et universitet. Ved at fokusere pa vanskelige situationer onsker artiklen at diskutere, hvad der sker, nar laerere og studerende sammen udforsker egne roller i de utydeligt afgraensede mellemrum og spaendinger mellem praksisformerne undervisning, forskning og kunst. I forste del av artiklen praesenteres didaktiske, kunstneriske og metodiske aspekter af forskningsprojektet Art as Education/Education as Art, hvor min kollega og jeg i efteraret 2016 sammen gennemforte en …

Softening of Silica Filled Styrene-Butadiene Rubber under Uniaxial Cyclic Loading

2016

Stress-strain behaviour of silica filled styrene-butadiene rubber showed strong hysteresis and cyclic softening, while these effects were almost negligible for the neat rubber. Significant Mullins effect occurs between the first and second loading cycles, whereupon samples reach their steady state after four repeated cycles. The degree of softening increases with volume content of silica characterizing the softening effect as a breakdown of the filler-formed microstructure defined by both, specific interactions in the filler associations and between the filler and rubber matrix. Contribution of different damage mechanisms to the total energy losses on different stages of extension was estim…

A minireview on NHE1 inhibitors. A rediscovered hope in oncohematology.

2015

Background: Na+/H+ exchanger-1 (NHE-1) is involved in pH regulation and is up-regulated in different malignancies. Activation of NHE-1 is one way for allowing cells to avoid intracellular acidification and protect them against apoptosis. Inhibitors of NHE-1 are able to decrease intracellular pH and induce apoptosis. Some statins can also act by partial inhibition of NHE-1. This review presents progress in understanding the mechanisms of action of these inhibitors, connections with certain genetic mutations and acquired treatment resistance, as well as new patents on them. Methods: A MEDLINE search for original and review articles using key terms, Na+/H+ exchanger, leukemia, cariporide, and …