Search results for "TYR"
showing 10 items of 2017 documents
Radioactively labelled epoxides. Part VI. tritium-labelled mono- and dimethyl substituted phenyl oxiranes (styrene oxides)
1988
Tritium-labelled (E)- and (Z)-2,3-dimethyl-2-phenyl oxirane 4, (E)- and (Z)-2-methyl-3-phenyl oxirane 7 and 2,2-dimethyl-3-phenyl oxirane 11 have been prepared by reduction of the corresponding bromoketones with sodium borotritide to the corresponding bromohydrins followed by cyclization to the oxiranes. These oxiranes were successfully used as diagnostic substrates to distinguish between different forms of epoxide hydrolase and glutathione transferase.
Stamping of monomeric SAMs as a route to structured crystallization templates: patterned titania films.
2000
Gold-coated glass slides have be patterned by using self-assembled monolayers (SAM) of alkane thiols. Through the use of a special thiol terminated with a styrene monomer, microstructures of 5 to 10 microm width and 70 A height have been formed on the surface by graft polymerization of styrene. These patterned gold slides have then been used to template the precipitation of thin titania films from ethanolic solutions of titanium isopropoxide to create microstructured architectures in the film. Plasmon resonance spectra have established the presence of different steps in the process and have been used to follow the kinetics of the precipitation of titania on the surface. The structured TiO2 …
Conductance in isodielectric mixtures. I.n-butyronitrile with dioxane, benzene, and carbon tetrachloride
1974
The conductance of tetrabutylammonium tetraphenylboride, picrate, nitrate, and bromide has been measured at 25°C inn-butyronitrile and in mixtures of this solvent with dioxane, benzene, and carbon tetrachloride covering the range of dielectric constants from 10–24.26. For the picrate, nitrate, and bromide, the association constants at a given dielectric constant are independent of the chemical composition of the solvent. The changes of Walden products with solvent composition, however, are different, depending on which other solvent is mixed with the butyronitrile.
Conductance in isodielectric mixtures. III.i-butyronitrile with chlorobenzene,o-dichlorobenzene,p-dichlorobenzene, 1,2-dichloroethane, andn-pentanol
1975
The conductance of tetrabutylammonium tetraphenylboride, picrate, perchlorate, and nitrate has been measured at 25°C in mixtures ofi-butyronitrile with chlorobenzene,o-dichlorobenzene,p-dicholorobenzene, 1,2-dichloroethane, andn-pentanol covering the range of dielectric constants 10≤D≤20. In these mixtures of polar solvents, both association constants and ionic mobilities depend on ion-solvent interaction energies and on free volume in a manner that is specific for each system. This failure of the primitive model (rigid charged spheres in a continuum) is shown to be the consequence of short-range spatial and energetic interactions between ions and adjacent solvent molecules.
1H,13C and17O NMR study of aromatic ring-substituted monochloro- and monobromo-(E)-3-phenylpropenals
1991
Trans-Cinnamaldehydes (CAs) or o-, m- and p-X-(E)-3-phenylpropenals; (X = Cl or Br) were synthesized and their 1H, 13C and 17O NMR spectra were measured, assigned and analysed. The long-range benzylic couplings are discussed in terms of the conformational characteristics of the related styrene systems. The 1H, 13C and 17O NMR substituent chemical shifts of the CA derivatives were compared with those of styrene and explained by the π-electron delocalization in the conjugated CCCO bond system of CA.
Photobinding of Tiaprofenic Acid and Subprofen to Proteins and Cells: A Combined Study Using Radiolabeling, Antibodies and Laser Flash Photolysis of …
1998
Drug photoallergy is a matter of current concern. It involves the formation of drug-protein photoadducts (photoantigens) that may ultimately trigger an immunological response. Tyrosine residues appear to be key binding sites in proteins. The present work has investigated the photobinding of tiaprofenic and (TPA) and the closely related isomer suprofen (SUP) to proteins and cells by means of radioactive labeling and drug-directed antibodies. To ascertain whether preassociation with the protein may play a role in photoreactivity, two model bichromophoric compounds (TPA-Tyr and SUP-Tyr) have been prepared and studied by laser flash photolysis. The results of this work show that (a) TPA and SUP…
Clinical Course and Significance of the Novel FLT3-Y842C Mutation in a Patient with AML Treated with PKC412 Monotherapy.
2004
Abstract We recently identified a novel mutation (Y842C) within the tyrosine kinase domain of FLT3 in a patient treated with PKC410 monotherapy (ASH 2003, # 4681). Here, we present follow up studies including the clinical course of the patient and frequency analysis in 110 patients with AML. In addition, we characterized the novel mutation using overexpression of FLT3-Y842C in 32D cells. AML M2 was diagnosed in a 63 year old, male patient in 1993. After having experienced his second relapse upon standard therapy the patient was refractory to alemtuzumab treatment. Due to reduced performance status the patient was not eligible to standard chemotherapy and was enrolled into a phase II trial i…
Preclinical and clinical evidence of activity of pazopanib in solitary fibrous tumour
2014
Abstract Background To explore the activity of pazopanib in solitary fibrous tumour (SFT). Patients and methods In a preclinical study, we compared the activity of pazopanib, sorafenib, sunitinib, regorafenib, axitinib and bevacizumab in a dedifferentiated-SFT (DSFT) xenotransplanted into Severe Combined Immunodeficiency (SCID) mice. Antiangiogenics were administered at their reported optimal doses when mean tumour volume (TV) was 80 mm3. Drug activity was assessed as TV inhibition percentage (TVI%). From May 2012, six consecutive patients with advanced SFT received pazopanib, on a national name-based programme. In one case sunitinib was administered after pazopanib failure. Results In the …
Phase-distribution chromatography (PDC) of polystyrene
1970
A chromatographic technique is described where the stationary phase is a layer of a very high molecular polystyrene fraction (M = 107) on glass beads (ballotines). The mobile phase is cyclohexane passing the column at a constant temperature below the theta-temperature. A polystyrene sample of sufficiently low molecular weight (M ≤ 106) injected as a small plug at the top of the column is fractionated because the distribution between the mobile and the stationary phase depends on the molecular weight. Since the large molecules preferentially remain in the stationary phase, the smaller molecules leave the column first. The fractionation effect is inverse to that found in GPC experiments. The …
Do too many choices have negative consequences? An empirical review
2013
Various experiments demonstrated that having too much choice has negative consequences on the motivation to choose and on the satisfaction with the chosen option. However, the literature reports conflicting results showing that choosing from large assortments has advantages. This paper reviews the main empirical results in favor and against the negative effect of too much choice and identifies possible directions for further research. Copyright © 2013 by Società editrice il Mulino.