Search results for "Tablet"
showing 10 items of 133 documents
Biowaiver Monographs for Immediate-Release Solid Oral Dosage Forms: Enalapril
2018
Literature data relevant to the decision to allow a waiver of in vivo bioequivalence testing for the marketing authorization of immediate-release, solid oral dosage forms containing enalapril maleate are reviewed. Enalapril, a prodrug, is hydrolyzed by carboxylesterases to the active angiotensin-converting enzyme inhibitor enalaprilat. Enalapril as the maleate salt is shown to be highly soluble, but only 60%-70% of an orally administered dose of enalapril is absorbed from the gastrointestinal tract into the enterocytes. Consequently, enalapril maleate is a Biopharmaceutics Classification System class III substance. Because in situ conversion of the maleate salt to the sodium salt is sometim…
IVIVC for fenofibrate immediate release tablets using solubility and permeability as in vitro predictors for pharmacokinetics.
2010
The goal of this study was to investigate the in vitro-in vivo correlation (IVIVC) for fenofibrate immediate release (IR) tablet formulations based on MeltDose-technique. The in vitro determined drug solubility and permeability data were related to the C(max) values observed from two in vivo human studies. Solubility and permeation studies of fenofibrate were conducted in medium simulating the fasted state conditions in the upper jejunum, containing the surfactant compositions of the six formulations at different concentrations. The behavior of all surfactant compositions was characterized by surface tension, dynamic light scattering, and cryo-TEM. The obtained solubility and permeation dat…
Introduction de dispositifs mobiles au sein d'établissements scolaires : analyse critique de comptes-rendus d'expérimentations
2014
International audience; Les comptes-rendus d'expérimentations d'introduction de tablettes numériques dans l'enseignement secondaire nous permettent de comprendre les objectifs, les méthodes utilisées et les conclusions émises. Nous apprenons ainsi que ces tests sont centrés sur l'outil et sur la pratique professionnelle des enseignants. Les questions de l'appropriation, des pratiques informelles, des usages sociaux des élèves ne sont pas envisagées dans les objectifs alors que ces aspects apparaissent dans les conclusions. Notre analyse nous conduit à formaliser les défis posés par les tablettes à l'école, à savoir : construire une ingénierie pédago-numérique, mettre en place une méta-pédag…
Bezūdens kalcija hidrogēnfosfāta izmantošana zopiklona tablešu ražošanā
2015
Bezūdens kalcija hidrogēnfosfāts ir plaši izmantota palīgviela, ko izmanto farmācijā, medicīnā un pārtikas ražošanā. Bezūdens kalcija hidrogēnfosfāts nodrošina zopiklona tablešu presēšanās spēju, bet tā fizikāli-tehnoloģiskās īpašības var ietekmēt tabletes mehānisko izturību un pašu tabletes ražošanas procesu. Šajā darbā tika pētīta bezūdens kalcija hidrogēnfosfāta ietekme uz izplatītu nebenzodiazepīna klases miega līdzekli zopiklonu tablešu kvalitatīvajiem rādītājiem. Bezūdens kalcija hidrogēnfosfāta kvalitatīvo rādītāju noteikšanai tika izmantotas metodes: mikroskopija, daļiņu lieluma sadalījuma noteikšana ar lāzerdifrakciju, sietu analīze, birstošu vielu tilpuma blīvuma noteikšana un vie…
Tabletit opetuskäytössä : opettajien kokemuksia Mobiluck-hankkeesta
2013
Tableteista on muodostunut potentiaalinen vaihtoehto kouluissa käytettäväksi teknologiaksi. Tutkimuksessa haastateltiin yhteensä kahtatoista opettajaa Mobiluck- hankkeen lukioista. Tutkimusongelmana oli selvittää, miten tabletteja on hyödynnetty opetuksessa ja millaisia vaikutuksia niillä on ollut. Opettajien kokemuksien perusteella tablettien opetuskäytöstä muodostettiin pedagogisia esimerkkejä. Lisäksi kartoitettiin, miten opettajat käyttivät tablettia henkilökohtaisena välineenä, mitä hyötyä tableteista oli ja millaisia ongelmia kohdattiin. Tutkimuksessa havaittiin, että tabletti mahdollisti paikasta riippumattoman oppimisen ja opiskeltavan sisällön integroimisen autenttiseen maailmaan. …
Using assessment for learning mathematics with mobile tablet based solutions
2014
Published version of an article in the journal: International Journal of Emerging Technologies in Learning (iJET). Also available from the publisher: http://dx.doi.org/10.3991/ijet.v9i2.3219 This article discusses assessment for learning in mathematics subjects. Teachers of large classes face the challenge of regularly assessing students’ ongoing mathematical learning achievements. Taking the complexity of assessment and feedback for learning as a background, we have developed a new approach to the assessment for learning mathematics at university level. We devised mobile tablet technology supported assessment processes, and we carried out user studies in both Rwanda and Norway. Results of …
Rizatriptan in the treatment of migraine.
2006
Migraine is a common, disabling disorder associated with considerable personal and societal burden. Current guidelines recommend triptans for the acute treatment of migraine unlikely to respond to less effective therapies. Rizatriptan is a second-generation triptan available in tablet or orally disintegrating tablet (wafer) formulations that offers several advantages over other members of its class. Rizatriptan is rapidly absorbed from the gastrointestinal tract and achieves maximum plasma concentrations more quickly than other triptans, providing rapid pain relief. Clinical trials have shown that rizatriptan is at least as effective or superior to other oral migraine-specific agents in the…
In vitro models for the prediction of in vivo performance of oral dosage forms: Recent progress from partnership through the IMI OrBiTo collaboration
2019
The availability of in vitro tools that are constructed on the basis of a detailed knowledge of key aspects of gastrointestinal (GI) physiology and their impact on formulation performance and subsequent drug release behaviour is fundamental to the success and efficiency of oral drug product development. Over the last six years, the development and optimization of improved, biorelevant in vitro tools has been a cornerstone of the IMI OrBiTo (Oral Biopharmaceutics Tools) project. By bringing together key industry and academic partners, and by linking tool development and optimization to human studies to understand behaviour at the formulation/GI tract interface, the collaboration has enabled …
Enteric-coated mycophenolate sodium in the treatment of refractory pemphigus.
2010
BACKGROUND: One of the major goals of pemphigus therapy is to reduce the patient's cumulative exposure to systemic corticosteroids. To investigate the efficacy of enteric-coated mycophenolate sodium (EC-MPS), 10 patients with active, refractory pemphigus vulgaris (PV) or foliaceous (PF) were treated with EC-MPS (1440 mg daily) and prednisone (75 mg daily) over 18 months. OBSERVATIONS: Following EC-MPS/prednisone therapy, disease progression was inhibited between days 30 and 45 in 9/10 patients (8 PV; 1 PF). At 18 months, 8/9 PV patients had clinically quiescent disease; EC-MPS therapy was no longer required in two patients as a result of disease remission. The remaining PV patient showed no…
Mapping of the human visual cortex using image-guided transcranial magnetic stimulation
2002
We describe a protocol using transcranial magnetic stimulation (TMS) to systematically map the visual sensations induced by focal and non-invasive stimulation of the human occipital cortex. TMS is applied with a figure of eight coil to 28 positions arranged in a 2x2-cm grid over the occipital area. A digitizing tablet connected to a PC computer running customized software, and audio and video recording are used for detailed and accurate data collection and analysis of evoked phosphenes. A frameless image-guided neuronavigational device is used to describe the position of the actual sites of the stimulation coils relative to the cortical surface. Our results show that TMS is able to elicit p…