Search results for "Tact"
showing 10 items of 1313 documents
Mast Cells Are Key Promoters of Contact Allergy that Mediate the Adjuvant Effects of Haptens
2011
SummaryA prominent feature of sensitizing environmental compounds that cause allergic contact dermatitis is the rapid induction of an innate inflammatory response that seems to provide danger signals for efficient T cell priming. We generated mouse models of mast cell deficiency, mast cell-specific gene inactivation, and mast cell reporter mice for intravital imaging and showed that these adjuvant effects of contact allergens are mediated by mast cells and histamine. Mast cell deficiency resulted in impaired emigration of skin DCs to the lymph node and contact hypersensitivity was dramatically reduced in the absence of mast cells. In addition, mast cell-specific inactivation of the Il10 gen…
Major histocompatibility complex regulation of the class of the immune response: the H-2d haplotype determines poor interferon-γ response to several …
1990
The lymph node cells of CBA (H-2k), but not BALB/c (H-2d) mice, release interferon (IFN)-gamma into the supernatant when immunized with picryl chloride epicutaneously and then exposed to antigen (haptenized cells) in vitro 4 days later. The failure in IFN-gamma production maps to the major histocompatibility complex (MHC; H-2d) in the congenic BALB/c, BALB/k and BALB/b mice. The evidence that this is an MHC regulation of the class of response to a range of antigens and not a classical Ir gene effect is (a) the difference is seen with several antigens including picryl chloride, "oxazolone" and purified protein derivative of tuberculin and (b) BALB/c mice, which fail to produce IFN-gamma, sho…
Tactile field and the dual nature of touch: Poster
2021
I investigate whether it is justified to postulate tactile field analogous in its properties to visual field. I argue that the answer is both ‘yes’ and ‘no’ due to the dual nature of touch: touch is both an interoceptive modality which presents states of one’s body and an exteroceptive modality which presents external entities. More specifically, the interoceptive tactile space, in which tactile bodily sensations are experienced to be localized, has a character of a spatial field. On the other hand, the exteroceptive tactile space, in which external, tactile objects are experienced to be localized does not have field-status.
Update of immune events in the murine contact hypersensitivity model: toward the understanding of allergic contact dermatitis.
2013
Allergic contact dermatitis (ACD) is one of the most common skin diseases, consisting of sensitization and elicitation phases. With the advancement of technology and the discovery of new types of immune cells, our knowledge of the immunological mechanisms of contact hypersensitivity (CHS) as a murine model of ACD has expanded significantly in the past decade. For example, by introducing regulatory T cells, CD4(+) T-helper 17 cells, and Langerin-positive dermal dendritic cells, the initiation and termination mechanism of CHS has been revealed. In addition, the role of mast cells in CHS, long a matter of debate, has become apparent by developing conditional mast cell-deficient mice. Moreover,…
Application of Chemical Cues in Arthropod Pest Management for Orchards and Vineyards
2013
This chapter reviews the literature on semiochemical-parasitoid systems in perennial crops. The first part of the chapter analyses the possible effects of pheromone-based tactics on parasitoid efficacy. In both orchards and vineyards, the most successful application of synthetic sex pheromones has been their use as mating disruptants. It also discusses the possibility of using parasitoid pheromones to directly affect parasitoid behaviour. The second part of the chapter summarizes research in orchards and vineyards that has tested whether synthetic chemical cues such as herbivore-induced plant volatiles (HIPVs) and host-associated volatiles (HAVs) can be used to manipulate parasitoid behavio…
A Cohesive-Frictional Interface Model with Frictional Properties Degradation
2009
The paper is devoted to an interface constitutive modeling which couples a cohesive behavior, based on the damage mechanics theory, with a frictional one, defined in a non-associative plasticity framework. By means of a specific interpretation of the damage variable, the formulation follows the transition of the initial sound interface material layer, up to the fully cracked condition. The macrocrack surfaces have initial frictional properties and is subjected to degradation phenomena. Namely, the smoothing and breaking of surface asperities cause a progressive reduction of dilatancy effects and also of the frictional angle. These phenomena are modeled as uncoupled: dilatancy saturation is …
Prevention and reversal of superantigen-induced anergy by contact allergen exposure
1995
The superantigen Staphylococcal enterotoxin B (SEB) and the contact allergen 2,4-dinitrofluorbenzene (DNFB) both react with V beta 8+ T-cells delivering distinct signals. Pre-treatment with DNFB painted onto the same skin site where SEB was to be injected, prevented the induction of anergy in V beta + T-cells that was otherwise induced after SEB had been injected intradermally over a period of 2 weeks. Application of the irritant sodium dodecyl sulfate (SDS) instead of DNFB did not exert this effect. Application of DNFB at a site distant from the site where SEB was injected resulted in a much weaker inhibitory influence on the induction of anergy by SEB. Established anergy of V beta 8+ T-ce…
Adoption of a COVID-19 Contact Tracing App Among Older Internet Users in Finland
2022
The outbreak of the COVID-19 pandemic created an unequal need for limiting physical contacts and tracing possible exposures to a novel coronavirus. Smartphone-based contact tracing applications (CTAs) were presented as a vehicle for stopping virus transmission chains and supporting the work of contact tracing teams. In this study, older adults’ adoption of a CTA was studied using socioeconomic background factors, satisfaction with health, and the measure of digital activity as predictors. The data were drawn from a larger questionnaire survey targeted at older internet users. A subsample of older Finnish internet users (N = 723) was analyzed using a logistic regression model. Results showed…
Comparative studies of ferric green rust and ferrihydrite coated sand: Role of synthesis routes
2008
International audience; A comparative study of ferrihydrite and ferric green rust coated sand prepared by three synthesis routes has been outlined in the present contribution. The two minerals displayed inverse properties in terms of quantity of deposited iron for all three methods investigated. For ferric green rust coating, a newly proposed synthesis route named as dry contact method was efficient for the maximum quantity of iron with almost full coverage area. Considering the similar parameters, the modified wet synthesis method designated as reactive method provides the optimum results for ferrihydrite coated sand. These coatings have been characterised by different surface analysis tec…