Search results for "Tatin"

Chemoprevention for hepatocellular carcinoma: the role of statins

2013

Non-linear evolutions of magnetized thick discs around black holes: dependence on the initial data

2020

We build equilibrium solutions of magnetised thick discs around a highly spinning Kerr black hole and evolve these initial data up to a final time of about 100 orbital periods. The numerical simulations reported in this paper solve the general relativistic magnetohydrodynamics equations using the BHAC code and are performed in axisymmetry. Our study assumes non-self-gravitating, polytropic, constant angular momentum discs endowed with a purely toroidal magnetic field. In order to build the initial data we consider three approaches, two of which incorporate the magnetic field in a self-consistent way and a third approach in which the magnetic field is included as a perturbation on to an othe…

Propagation and stability of relativistic jets

2020

A simple look at the steady high-energy Universe reveals a clear correlation with outflows generated around compact objects (winds and jets). In the case of relativistic jets, they are thought to be produced as a consequence of the extraction of rotational energy from a Kerr black hole (Blandford-Znajek), or from the disc (Blandford-Payne). A fraction of the large energy budget provided by accretion and/or black hole rotational energy is invested into jet formation. After formation, the acceleration and collimation of these outflows allow them to propagate to large distances away from the compact object. The synchrotron cooling times demand that re-acceleration of particles takes place alon…

Influence of pions and hyperons on stellar black hole formation

2013

We present numerical simulations of stellar core-collapse with spherically symmetric, general relativistic hydrodynamics up to black hole formation. Using the CoCoNuT code, with a newly developed grey leakage scheme for the neutrino treatment, we investigate the effects of including pions and \Lambda-hyperons into the equation of state at high densities and temperatures on the black hole formation process. Results show non-negligible differences between the models with reference equation of state without any additional particles and models with the extended ones. For the latter, the maximum masses supported by the proto-neutron star are smaller and the collapse to a black hole occurs earlie…

Low frequency gray-body factors and infrared divergences: rigorous results

2015

Formal solutions to the mode equations for both spherically symmetric black holes and Bose-Einstein condensate acoustic black holes are obtained by writing the spatial part of the mode equation as a linear Volterra integral equation of the second kind. The solutions work for a massless minimally coupled scalar field in the s-wave or zero angular momentum sector for a spherically symmetric black hole and in the longitudinal sector of a 1D Bose-Einstein condensate acoustic black hole. These solutions are used to obtain in a rigorous way analytic expressions for the scattering coefficients and gray-body factors in the zero frequency limit. They are also used to study the infrared behaviors of …

Superconformal mechanics, black holes, and non-linear realizations

1998

The OSp(2|2)-invariant planar dynamics of a D=4 superparticle near the horizon of a large mass extreme black hole is described by an N=2 superconformal mechanics, with the SO(2) charge being the superparticle's angular momentum. The {\it non-manifest} superconformal invariance of the superpotential term is shown to lead to a shift in the SO(2) charge by the value of its coefficient, which we identify as the orbital angular momentum. The full SU(1,1|2)-invariant dynamics is found from an extension to N=4 superconformal mechanics.

Homozygous familial hypercholesterolaemia: new insights and guidance for clinicians to improve detection and clinical management. A position paper fr…

2014

Item does not contain fulltext AIMS: Homozygous familial hypercholesterolaemia (HoFH) is a rare life-threatening condition characterized by markedly elevated circulating levels of low-density lipoprotein cholesterol (LDL-C) and accelerated, premature atherosclerotic cardiovascular disease (ACVD). Given recent insights into the heterogeneity of genetic defects and clinical phenotype of HoFH, and the availability of new therapeutic options, this Consensus Panel on Familial Hypercholesterolaemia of the European Atherosclerosis Society (EAS) critically reviewed available data with the aim of providing clinical guidance for the recognition and management of HoFH. METHODS AND RESULTS: Early diagn…

Blocking Activin Receptor Ligands Is Not Sufficient to Rescue Cancer-Associated Gut Microbiota—A Role for Gut Microbial Flagellin in Colorectal Cance…

2019

Colorectal cancer (CRC) and cachexia are associated with the gut microbiota and microbial surface molecules. We characterized the CRC-associated microbiota and investigated whether cachexia affects the microbiota composition. Further, we examined the possible relationship between the microbial surface molecule flagellin and CRC. CRC cells (C26) were inoculated into mice. Activin receptor (ACVR) ligands were blocked, either before tumor formation or before and after, to increase muscle mass and prevent muscle loss. The effects of flagellin on C26-cells were studied in vitro. The occurrence of similar phenomena were studied in murine and human tumors. Cancer modulated the gut microbiota witho…

Salivary protein profiles and sensitivity to the bitter taste of caffeine.

2011

WOS: 000298381900008; International audience; The interindividual variation in the sensitivity to bitterness is attributed in part to genetic polymorphism at the taste receptor level, but other factors, such as saliva composition, might be involved. In order to investigate this, 2 groups of subjects (hyposensitive, hypersensitive) were selected from 29 healthy male volunteers based on their detection thresholds for caffeine, and their salivary proteome composition was compared. Abundance of 26 of the 255 spots detected on saliva electrophoretic patterns was significantly different between hypo- and hypersensitive subjects. Saliva of hypersensitive subjects contained higher levels of amylase…

Induction of cholesterol biosynthesis by archazolid B in T24 bladder cancer cells.

2014

Abstract Background Resistance of cancer cells towards chemotherapeutics represents a major cause of therapy failure. The objective of our study was to evaluate cellular defense strategies in response to the novel vacuolar H+-ATPase inhibitor, archazolid B. Experimental approach: The effects of archazolid B on T24 bladder carcinoma cells were investigated by combining “omics” technologies (transcriptomics (mRNA and miRNA) and proteomics). Free cholesterol distribution was determined by filipin staining using flow cytometry and fluorescence microscopy. Flow cytometry was performed for LDLR surface expression studies. Uptake of LDL cholesterol was visualized by confocal microscopy. SREBP acti…