Search results for "Tenascin"

072 Collagen gene expression and tenascin pattern in normal, osteoarthritic, and rheumatoid connective tissues

1992

The extracellular matrix consists of four major components, namely collagens, elastin, proteoglyeans and glycoproteins. Collagens are important members of the ECM, forming a family of at least t 3 different structurally related proteins. Tenascin, synonymous with cytoactin, hexabrachion and J1, is a new member of matrix glycoproteins with a molecular mass of 1200 kD. It exhibits a "hexabrachion" structure with an ellipsoid central globule from which six arms of 75 nm in length diverge in a T-junction arrangement [1]. Rheumatoid arthritis (RA) belongs to the group of connective tissue diseases. In contrast to abundant data about ECM-changes in systemic sclerodermia [2] the matrix alterations…

Tenascin gene expression in rat liver and in rat liver cells. In vivo and in vitro studies.

1991

Tenascin is a major glycoprotein constituent of the extracellular matrix with a strong affinity to fibronectin; its distribution is believed to be temporarily and spatially limited. Tenascin gene expression is increased during wound healing processes. As repair mechanisms in chronic liver diseases resemble wound healing we studied tenascin gene expression in rat liver and in isolated rat liver cells. In normal rat liver a tenascin specific antiserum stains sinusoidal cells with fiber-like prolongations, which at the same time are desmin-positive (ITO-cells). In the CCl4-acutely-damaged liver a strong tenascin staining is detected in cells located among the mononuclear cells of the inflammat…

Expression of tenascin in human cervical cancer--association of tenascin expression with clinicopathological parameters.

1999

Tenascin is an extracellular matrix glycoprotein, relevant for embryonal and fetal development, which is reexpressed in the stroma of benign and malignant tumors. Little is known about the molecular interaction of tenascin during neoplastic transformation and tumor progression in cervical cancer.We studied the expression of tenascin in normal tissue of the cervix uteri, cervical carcinoma in situ, and invasive cervical carcinoma in paraffin sections by immunohistochemistry using a monoclonal antibody. Tenascin immunoreactivity was compared with various prognostic parameters.In normal cervical tissue (n = 5) and in cervical carcinoma in situ (n = 10) only vessel walls showed a weak tenascin …

Considering Genetics in Tendinopathy Management

2018

Impaired border zone formation and adverse remodeling after reperfused myocardial infarction in cannabinoid CB2 receptor deficient mice.

2014

Abstract Aims Reperfusion of myocardial infarction is associated with inflammatory reaction and subsequent myocardial remodeling with a rapid scar formation in mice. The cannabinoid receptor CB2 has been associated with cardioprotection and regulation of macrophage function. We investigated its role in remodeling of reperfused infarction. Main methods One hour LAD-occlusion was followed by reperfusion over 6 h and 1, 3 and 7 days in wild-type C57/BL6J (WT) and CB2 receptor-deficient (Cnr2 −/− ) mice (n = 8/group). Hearts were processed for functional, morphological and mRNA/protein analysis, and tissue concentration of endocannabinoids was determined using liquid chromatography-multiple rea…