Search results for "Terminal"
showing 10 items of 364 documents
Catecholamine release in human skin--a microdialysis study.
2003
Dermal microdialysis might be a promising tool to investigate properties of sympathetic neurons in the skin as investigation of peripheral noradrenergic neurons in humans usually relies on highly variable vasoconstrictor reflexes or on indirect measurements like skin temperature recordings. To evaluate this technique, 21 experiments were performed in 15 healthy subjects with four intracutaneous microdialysis fibers (diameter, 200 microm; cutoff, 5 kDa) at hands or feet. After 60 min, saline perfusion tyramine at concentrations of 0.195 to 200 microg/ml was applied for 15 min followed by a 15-min saline perfusion again. Catecholamine concentrations were detected through high-performance liqu…
Segregated pathways to the vomeronasal amygdala: differential projections from the anterior and posterior divisions of the accessory olfactory bulb.
2007
Apically and basally located receptor neurons in the vomeronasal sensory epithelium express G(i2 alpha)- and G(o alpha)-proteins, V1R and V2R vomeronasal receptors, project to the anterior and posterior accessory olfactory bulb and respond to different stimuli, respectively. The extent to which secondary projections from the two portions of the accessory olfactory bulb are convergent in the vomeronasal amygdala is controversial. This issue is addressed by using anterograde and retrograde tract-tracing methods in rats including electron microscopy. Injections of dextran-amines, Fluoro Gold, cholera toxin-B subunit and Fast Blue were delivered to the anterior and posterior accessory olfactory…
Presynaptic CB1 Receptors Regulate Synaptic Plasticity at Cerebellar Parallel Fiber Synapses
2011
Endocannabinoids are potent regulators of synaptic strength. They are generally thought to modify neurotransmitter release through retrograde activation of presynaptic type 1 cannabinoid receptors (CB1Rs). In the cerebellar cortex, CB1Rs regulate several forms of synaptic plasticity at synapses onto Purkinje cells, including presynaptically expressed short-term plasticity and, somewhat paradoxically, a postsynaptic form of long-term depression (LTD). Here we have generated mice in which CB1Rs were selectively eliminated from cerebellar granule cells, whose axons form parallel fibers. We find that in these mice, endocannabinoid-dependent short-term plasticity is eliminated at parallel fiber…
pRb suppresses camptothecin-induced apoptosis in human osteosarcoma Saos-2 cells by inhibiting c-Jun N-terminal kinase
2001
AbstractThis paper studies the cytotoxic effect induced by the topoisomerase I inhibitor camptothecin in human osteosarcoma Saos-2 cells, which lack p53 and contain a non-functional form of the product of the retinoblastoma gene, pRb. Cytotoxicity induced by camptothecin was dose- and time-dependent; the treatment with 100 nM camptothecin reduced cell viability by 50% at 32 h and by 75% at 72 h of exposure. The cytotoxic effect was caused by apoptosis, as ascertained by morphological evidence, acridine orange-ethidium bromide staining and flow cytometric analysis. Apoptosis was accompanied by both the activation of caspase-3 and the fragmentation of poly(ADP-ribose) polymerase. Treatment wi…
Fiber Connections of the Amygdaloid Formation of the Lizard <i>Podarcis hispanica</i>
1993
The amygdaloid formation of the lizard Podarcis hispanica can be divided into three main groups of nuclei on the basis of their input from the main and accessory olfactory bulbs: the vomeronasal amygdala, the olfactory amygdala and the dorsal amygdaloid group, the latter group receiving afferents from neither the main (MOB) or the accessory olfactory bulb (AOB). The vomeronasal amygdala has a centrifugal projection to the AOB, an important commissural connection to the contralateral vomeronasal amygdala, a minor projection to nucleus accumbens, and a bilateral projection to the lateral cortex. The olfactory amygdala displays a bilateral afferents from the MOB, receives a contralateral affer…
Master-Slave Control of Battery/Supercapacitor Based Hybrid Energy Storage System for E-Vehicle Application
2022
In this paper, management and control problem of hybrid energy storage system (HESS) has been solved by master-slave control strategy. Heuristic fuzzy rules based algorithm is developed for optimal power sharing between different power sources. The master control is followed by a slave level controller, designed by using terminal synergetic control method for tracking. Moreover, the stability analysis of closed-loop system has been carried out by using lyapunov theory. Finally, the proposed method has been tested in MATLAB/Simulink environment under Worldwide Harmonised Light Vehicle Test Procedure (WLTP).
Application of queuing methodology to analyze congestion: A case study of the Manila International Container Terminal, Philippines
2016
The objective of this paper is to apply queuing methodology in order to analyze congestion at the Manila International Container Terminal (MICT) in the Port of Manila, the Philippines. The vessels calling at the MICT have to wait in a queue before receiving services at berths because of congestion. For vessel operators and cargo owners this situation creates waiting time costs and delays in delivery of goods to final customers. One option to decrease waiting time is to expand capacity by increasing the number of berths. Construction of a new berth is a time consuming and costly procedure, which needs to be considered carefully before being implemented. To determine whether the data collecte…
The terminal hyperspace of homogeneous continua
2010
Abstract We investigate the structure of the collection of terminal subcontinua in homogeneous continua. The main result is a reduction of this structure to six specific types. Three of these types are of one-dimensional spaces, and examples representing these types are known. It is not known whether higher dimensional examples having non-trivial terminal subcontinua and representing the three remaining types exist.
Sindrome del tunnel carpale: malattia professionale o patologia correlata al lavoro?
2011
La sindrome del tunnel carpale costituisce la più frequente neuropatia da compressione dell’arto superiore, originando dall’intrappolamento del nervo mediano nel canale carpale. Nel determinismo della sua comparsa risultano coinvolti numerosi fattori (precedenti fratture, traumatismi cronici, sport, hobbies, attività casalinghe). Vieppiù, è noto che tale malattia riconosce come primo momento etiopatogenetico non solo ripetuti movimenti di flesso-estensione del polso, ma anche malattie sistemiche o condizioni parafisiologiche (menopausa, gravidanza). La sindrome del tunnel carpale, se “secondaria” si manifesta generalmente con carattere di bilateralità soprattutto in donne tra i 30 ed i 60 a…
Synaptic vesicle alterations in rod photoreceptors of synaptophysin-deficient mice.
2001
Abstract The abundance of the integral membrane protein synaptophysin in synaptic vesicles and its multiple possible functional contributions to transmitter exocytosis and synaptic vesicle formation stand in sharp contrast to the observed lack of defects in synaptophysin knockout mice. Assuming that deficiencies are compensated by the often coexpressed synaptophysin isoform synaptoporin, we now show that retinal rod photoreceptors, which do not synthesize synaptoporin either in wild-type or in knockout mice, are affected by the loss of synaptophysin. Multiple pale-appearing photoreceptors, as seen by electron microscopy, possess reduced cytoplasmic electron density, swollen mitochondria, an…