Search results for "Terminal"
showing 10 items of 364 documents
(2'-5')Oligoadenylate and intracellular immunity against retrovirus infection.
1992
1. 1. The double-stranded RNA-dependent 2′,5′-oligoadenylate (2–5A) synthetase/ribonuclease L (RNase L) system plays an essential role in the establishment of the antiviral state of a cell exposed to virus infection. 2. 2. Until recently, the application of 2–5A derivatives to reinforce this system seemed to be limited mainly due to the low specificity of RNase L for viral RNA. 3. 3. Two new strategies have been developed which yield a selective antiviral effect of 2–5As at least against human immunodeficiency virus-1 (HIV-1) infection: (i) an “intracellular immunization” appproach using 2-5A synthetase cDNA linked to HIV trans -acting response element (TAR) and (ii) inhibition of retrovira…
European Society for Medical Oncology (ESMO) position paper on supportive and palliative care
2018
Oncology has come a long way in addressing patients' quality of life, together with developing surgical, radio-oncological and medical anticancer therapies. However, the multiple and varying needs of patients are still not beingmet adequately as part of routine cancer care. Supportive and palliative care interventions should be integrated, dynamic, personalised and based on best evidence. They should start at the time of diagnosis and continue through to end-of-life or survivorship. ESMO is committed to excellence in all aspects of oncological care during the continuum of the cancer experience. Following the 2003 ESMO stand on supportive and palliative care (Cherny N, Catane R, Kosmidis P. …
Optimal Management of Human Resources in Transhipment Container Ports
2014
Human resources allocation plays a key role in Transhipment Maritime Container Terminals to achieve high levels of productivity and provide high quality services to shipping companies. The deep interest of container terminals in this issue can be supported by optimization methods. In this work, an optimization model is proposed to determine the optimal daily allocation of crane operators and trailer drivers. Different requirements are taken into account for permanent staff, external workers and personnel shortfall. Since workforce undermanning is a crucial factor for both shipping companies and container terminals, we aim to show that personnel shortfalls and operation delays can be signifi…
Integer programming models for the pre-marshalling problem
2019
[EN] The performance of shipping companies greatly depends on reduced berthing times. The trend towards bigger ships and shorter berthing times places severe stress on container terminals, which cannot simply increase the available cranes indefinitely. Therefore, the focus is on optimizing existing resources. An effective way of speeding up the loading/unloading operations of ships at the container terminal is to use the idle time before the arrival of a ship for sorting the stored containers in advance. The pre-marshalling problem consists in rearranging the containers placed in a bay in the order in which they will be required later, looking for a sequence with the minimum number of moves…
A comparative evaluation between dermatoglyphic patterns and different terminal planes in primary dentition
2018
Background To assess the correlation between different dermatoglyphic patterns with the terminal planes in deciduous dentition. Material and methods 300 children who are 3-6 years old with complete primary dentition were recruited and the pattern of molar terminal plane was recorded in the proforma. Finger prints of the distal phalanges of these subjects were recorded using ink and roller method and were analysed for the finger print pattern by a forensic specialist. The pattern were classified based on classification given by Galton. The finger ridge counts were also measured. Results Ulnar loop pattern was the most predominant dermatoglyphic pattern. Absence of arch pattern in ring and li…
Estudio del papel de PBX1 como selector terminal de las neuronas dopaminérgicas del bulbo olfatorio
2021
Tesis doctoral 177 p, figuras y tablas.
The Ventian mammal age (Latest Miocene): present state
2013
[EN] The Ventian land mammal age includes most of the Spanish faunas assigned to the biochronologic unit MN 13. It is correlatable with the Messinian, although it may include, in its latest part, Early Pliocene faunas. We propose that the Ventian begins with the fi rst occurrence of the Muridae genus Stephanomys (7 Ma, paleomagnetic dating from El Bunker, Teruel basin), well recorded in Teruel basin, and ends with the appearance of Promimomys (ca. 5 Ma), also registered in the Teruel basin. We suggest a new reorganization of the Ventian. The first subdivision corresponds to the zone M (Dam et al., 2001). The second, zone N, is proposed here for the first time, being equivalent to the zone w…
Support for families of patients dying with dementia: A qualitative analysis of bereaved family members' experiences and suggestions
2014
AbstractObjective:To explore and document the needs of family caregivers of patients dying with dementia and to identify how healthcare professionals can adequately support them.Method:We employed a cross-sectional survey containing open-ended questions that were analyzed using qualitative methods.Results:Receiving information about the diagnosis and disease trajectory of dementia is essential for the caregiving families of people dying with the disease. However, at present the communication of information offered by professionals is not experienced as satisfying. Further aspects that require improvement concern issues related to time constraints, as well as practical and emotional support …
Mapping palliative care provision in European prisons
2021
ObjectivesPrison populations around the world are ageing and numbers are rising, leading to greater demand for palliative care for prisoners approaching the end of life. This paper reports a survey that was undertaken by the European Association for Palliative Care Task Force on mapping palliative care provision for prisoners in Europe. The Task Force was established to begin to address the gap in research knowledge by exploring prison systems and care provision across different countries.MethodsThe survey, developed by the Task Force Steering Committee, consisted of 40 questions in six sections. It was completed through online searches; only data that were publicly available on the interne…
Abnormal accumulation of autophagic vesicles correlates with axonal and synaptic pathology in young Alzheimer's mice hippocampus
2012
Dystrophic neurites associated with amyloid plaques precede neuronal death and manifest early in Alzheimer's disease (AD). In this work we have characterized the plaque-associated neuritic pathology in the hippocampus of young (4- to 6-month-old) PS1(M146L)/APP(751SL) mice model, as the initial degenerative process underlying functional disturbance prior to neuronal loss. Neuritic plaques accounted for almost all fibrillar deposits and an axonal origin of the dystrophies was demonstrated. The early induction of autophagy pathology was evidenced by increased protein levels of the autophagosome marker LC3 that was localized in the axonal dystrophies, and by electron microscopic identification…