Search results for "Termini"

The PAI-1 gene locus 4G/5G polymorphism is associated with a family history of coronary artery disease.

1998

Abstract —A family history of ischemic events is a major determinant of coronary artery disease (CAD). Plasma levels of plasminogen activator inhibitor 1 (PAI-1) modulate this risk. A deletion/insertion polymorphism within the PAI-1 locus (4G/5G) affects the expression of this gene. We investigated the relationship between the PAI-1 4G/5G polymorphism in 1179 healthy employees of our institution and the occurrence of CAD in their first-degree relatives. A family history of documented ischemic coronary disease was assessed by a modified WHO questionnaire. The PAI-1 4G/5G polymorphism was evaluated by polymerase chain reaction and endonuclease digestion. The group with a first-degree relativ…

A possible association between the CCK-AR gene and persistent auditory hallucinations in schizophrenia.

2004

AbstractRecent studies have suggested that DNA variations in the CCK-AR gene might predispose individuals to schizophrenia and particularly to auditory hallucinations (AH). The aim of this study is to assess the association between AH, using a specific scale for AH in schizophrenia (PSYRATS), and the CCK-AR polymorphism at 779 in a Spanish sample. A total of 105 DSM-IV schizophrenic patients with AH and 93 unrelated controls were studied. Twenty-two patients were considered as persistent auditory hallucinators, which showed similar clinical and demographic characteristic than patients with episodic AH, but with the exception of the PSYRATS values. The persistent AH group showed an excess of…

Smoking cessation and variations in nicotinic acetylcholine receptor subunits alpha-5, alpha-3, and beta-4 genes.

2009

Background Evidence has recently accumulated that single nucleotide polymorphisms in the genetic region encoding the nicotinic acetylcholine receptor subunits α-5, α-3, and β-4 are associated with smoking and nicotine dependence. We aimed to determine whether these genetic variations are also predictive of smoking cessation. Methods Lifetime history of smoking was assessed by questionnaire at enrolment into a large epidemiological study of the German elderly population (ESTHER study). Cox proportional hazards modeling was applied in a retrospective cohort approach to determine the associations of individual polymorphisms and haplotypes with smoking cessation probability in 1446 subjects who…

No primary association between LMP2 polymorphisms and extraspinal manifestations in spondyloarthropathies

1997

OBJECTIVE—To investigate the potential role of the HLA-linked LMP2 (low molecular weight protein) gene polymorphisms in conjunction with DR4 and DR7 on extraspinal disease manifestations in HLA-B27 positive patients with spondyloarthropathy.
METHODS—172 patients with spondyloarthropathy, 46 healthy, HLA-B27 positive blood donors, and 99 unrelated controls were typed for HLA-class I and II antigens. LMP2 alleles were determined by polymerase chain reaction and subsequent restriction enzyme digestion.
RESULTS—There were statistically non-significant increases of DR4 and DR7 in spondyloarthropathy subjects. However these differences did not relate to specific extraspinal manifestations. There …

Association study of a SNP coding for a M129V substitution in the prion protein in schizophrenia.

2003

Similar contributions of BRCA1 and BRCA2 germline mutations to early-onset breast cancer in Germany.

2003

This study was undertaken to investigate the prevalence of BRCA1 and BRCA2 germline mutations in 91 German patients unselected for family history, who were diagnosed with breast cancer before the age of 41 years. Clinical information and blood samples were obtained from all patients. A comprehensive BRCA1 and BRCA2 mutational analysis was performed using the protein truncation assay and single-strand conformational polymorphism analysis followed by DNA sequencing of variant signals detected by these assays. Five different deleterious germline mutations including four frameshift mutations and one missense mutation were identified, three in BRCA1 (3.3%) and two mutations (2.2%) in BRCA2. Both…

Aspetti tipo-cronologici e archeometrici delle ceramiche africane nel territorio di Cignana (Naro, AG, Sicilia)

2020

Il progetto di ricerca, condotto in cotutela tra l'Università di Palermo e Aix-Marseille Université, si basa sullo studio delle ceramiche africane importate in Sicilia tra la fine del I e il VII secolo d.C.. La ricerca si basa sui frammenti - tutte le classi incluse - raccolti dal gruppo di ricerca di Palermo durante le ricognizioni archeologiche nei dintorni della villa romana di Cignana (Agrigento) e nell'entroterra di Termini Imerese (Palermo). L'approccio multidisciplinare archeologico ed archeometrico, condotto in collaborazione con diversi specialisti di queste discipline, ha permesso di definire l'origine delle diverse produzioni e di riflettere sulla loro circolazione in Sicilia, in…

Sex differences in genetic and environmental effects on aggression

2003

The aim of the present study was to investigate the genetic and environmental factors influencing teacher and parental rated aggression in boys and girls, asking whether the magnitude of these effects is similar across rater and sex. The study is part of an ongoing nationwide twin-family study of behavioral development and health habits carried out in Finland. The sample consisted of 1651 twin pairs (264 monozygotic male, 300 monozygotic female, 292 dizygotic male, 278 dizygotic female, and 517 dizygotic opposite-sex twin pairs), representing subsets of five 11- to 12-year-old twin cohorts (b. 1983-1987). The data were collected using the teacher and parental rating forms of the Multidimens…

Arithmetical Analysis of Biomolecular Finite Automaton

2013

In the paper we present a theoretical analysis of extension of the finite automaton built on DNA (introduced by the Shapiro team) to an arbitrary number of states and symbols. In the implementation we use a new idea of several restriction enzymes instead of one. We give arithmetical conditions for the existence of such extensions in terms of ingredients used in the implementation.

Nonstochastic languages as projections of 2-tape quasideterministic languages

1998

A language L (n) of n-tuples of words which is recognized by a n-tape rational finite-probabilistic automaton with probability 1-e, for arbitrary e > 0, is called quasideterministic. It is proved in [Fr 81], that each rational stochastic language is a projection of a quasideterministic language L (n) of n-tuples of words. Had projections of quasideterministic languages on one tape always been rational stochastic languages, we would have a good characterization of the class of the rational stochastic languages. However we prove the opposite in this paper. A two-tape quasideterministic language exists, the projection of which on the first tape is a nonstochastic language.