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RESEARCH PRODUCT
A possible association between the CCK-AR gene and persistent auditory hallucinations in schizophrenia.
C. NájeraMaría Dolores MoltóJ.c. GonzálezJulio SanjuánC. LealI. ToiracR. De Frutossubject
AdultMalemedicine.medical_specialtyPsychosisPeriodicityGenotypeHallucinationsSeverity of Illness IndexGenetic determinismLinkage Disequilibrium03 medical and health sciences0302 clinical medicineGene FrequencyInternal medicineSurveys and QuestionnairesSeverity of illnessmedicineHumansAlleleSex DistributionPsychiatryAllele frequencyGenetic associationDNA PrimersDemographyAuditory hallucinationPolymorphism Geneticmedicine.diseaseIntrons030227 psychiatryReceptor Cholecystokinin ADiagnostic and Statistical Manual of Mental DisordersPsychiatry and Mental healthEndocrinologySchizophreniaSchizophreniaFemalemedicine.symptomPsychology030217 neurology & neurosurgerydescription
AbstractRecent studies have suggested that DNA variations in the CCK-AR gene might predispose individuals to schizophrenia and particularly to auditory hallucinations (AH). The aim of this study is to assess the association between AH, using a specific scale for AH in schizophrenia (PSYRATS), and the CCK-AR polymorphism at 779 in a Spanish sample. A total of 105 DSM-IV schizophrenic patients with AH and 93 unrelated controls were studied. Twenty-two patients were considered as persistent auditory hallucinators, which showed similar clinical and demographic characteristic than patients with episodic AH, but with the exception of the PSYRATS values. The persistent AH group showed an excess of the A1 allele when was compared with episodic or control groups. Our data support the possible role of the CCK-AR gene in the development of persistent AH in schizophrenic patients.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2004-09-01 | European psychiatry : the journal of the Association of European Psychiatrists |