Search results for "Terpenoid"
showing 10 items of 221 documents
Cytotoxic activity of some natural and synthetic guaianolides
2005
Several natural guaianolides and synthetic derivatives of repin (1) were tested and found to be active against tumor cell replication. Repin (1) and both mono- and di-halohydrin analogues (2, 7-9, 11, 12) showed significant antitumor potency. A more effective compound (17) was obtained by esterificating repin with the paclitaxel side chain.
Composition of the essenthial oil of Petagnaea gussonei (Sprengel) Rauschert, a relict species from Sicily (Southern Italy).
2008
The essential oil from leaves, stems and roots of Petagnaea gussonei (Sprengel) Rauschert ( = Petagnia saniculifolia Guss.), endemic to the Nebrodi Mountains (Sicily, Italy), has been analysed by the gas chromatography–mass spectrometry (GC–MS) system on two fused-silica capillary columns of different polarities. A total of 94 components were identified. Quantitative and qualitative differences were found among the analysed parts. The principal compounds from the leaves oil were found to be (w/w%) germacrene D (19.9%), γ-muurolene (7.96%) and caryophyllene oxide (6.85%), while in the oil from stems hexadecanoic acid (23.40%), germacrene D (18.50%) and (Z,Z)-9,12-octadecadienoic acid (13.20%…
Euphosantianane E–G: Three New Premyrsinane Type Diterpenoids from Euphorbia sanctae-catharinae with Contribution to Chemotaxonomy
2019
Euphorbia species were widely used in traditional medicines for the treatment of several diseases. From the aerial parts of Egyptian endemic plant, Euphorbia sanctae-catharinae, three new premyrsinane diterpenoids, namely, euphosantianane E&ndash
Semisynthesis of the Antiviral Abietane Diterpenoid Jiadifenoic Acid C from Callitrisic Acid (4-Epidehydroabietic Acid) Isolated from Sandarac Resin
2014
The semisynthesis of the antiviral abietane diterpenoid (+)-jiadifenoic acid C starting from the available methyl ester of callitrisic acid (4-epidehydroabietic acid) isolated from sandarac resin is reported. A protocol for the isolation of methyl callitrisate (methyl 4-epidehydroabietate) in gram quantities from sandarac resin is also described. Allylic C-17 oxygenation was introduced by regioselective dehydrogenation of the isopropyl group of methyl callitrisate with DDQ followed by selenium-catalyzed allylic oxidation. Ester hydrolysis afforded (+)-jiadifenoic acid C in 22% overall yield from methyl callitrisate. This semisynthetic route provides a convenient source of this anti-Coxsacki…
A new irregular diterpenoid of biogenetic interest from the flowers of Magydaris tomentosa (Desf.) DC. (Apiaceae)
2007
A new irregular acyclic diterpene, magytomol acetate (2), has been isolated from the light petroleum extract of the flowers of Magydaris tomentosa (Desf.) DC. (Apiaceae) and its structure has been elucidated by means of extensive spectroscopic experiments. The new compound can be considered the acetyl derivative of the biogenetic precursor of other irregular diterpenes isolated from other species belonging to the family Apiaceae.
The Diterpenoids from the Genus Hyptis (Lamiaceae)
2009
The genus Hyptis (family Lamiaceae) is known mainly for the essential oils isolated from the aerial parts of several species. Less known are the diterpenoids, extracted from a limited number of species. In consideration of the interest for the structures of this class of compounds, largely occurring in the whole Lamiaceae family, the present paper means to review and update their chemistry. Also the use of many species of Hyptis in folk-medicine is reported.
Antimicrobial activity of selected plants employed in the Spanish mediterranean area. Part II
1989
The antimicrobial properties of 59 plants used in folk medicine to treat general infectious diseases were studied. The in vitro antimicrobial activity of chloroform and methanol plant extracts were assayed using the agar-streak method and 38 of them showed activity against some of the microorganisms tested. Bioautography established the probable active compounds. Inhibition bands were identified as containing terpenoids and polyphenolic compounds.
Effects of Terpenoids from Salvia Willeana in Delayed-type Hypersensitivity, Human Lymphocyte Proliferation and Cytokine Production
2008
The effect of the lipophilic extract of S. willeana and three terpenoids isolated therefrom, camphor, lupeol and oleanolic acid, on oxazolone-induced hypersensitivity was evaluated. The extract reduced the ear edema by 46% at 24 h after challenge. All three terpenoids inhibited the edema and suppressed cytokines release at different rates. Lupeol inhibited the swelling by over 50% and reduced the production of IL-1β by 62%. Camphor caused inhibition of the efferent phase (45% inhibition at 72 h) and the levels of IL-1β, IL-4 and TNF-α (around 80% inhibition). Oleanolic acid diminished moderately the reaction and the levels of IL-4 and TNF-α. We also demonstrated that the three terpenoids i…
Advances on the chemistry of furano-diterpenoids from Teucrium genus
2005
This paper updates the previous reviews, reporting the results published in the last six years on the chemistry of these diterpenoids.
A review of natural and modified betulinic, ursolic and echinocystic acid derivatives as potential antitumor and anti-HIV agents.
2003
The aim of this review is to update current knowledge on the betulinic, ursolic and echinocystic acids and their natural and semisynthetic analogs, focussing on their cytotoxic and anti-HIV activities. Then, the last results of the authors' team on unusual semisynthetic derivatives of these triterpenoids will be presented in order to establish structure/activity relationships.