Search results for "Testo"

Preventing bone loss during androgen deprivation therapy for prostate cancer: Early experience with neridronate

2005

Abstract Objective: Androgen-deprivation therapy (ADT) is the usual treatment for locally advanced or metastatic prostate cancer. Osteoporosis is a common complication of ADT. The aim of our study was to evaluate the efficacy of neridronate, a relatively new bisphosphonate to prevent bone loss during androgen ablation. Methods: Sixty patients with prostate cancer and osteoporosis were enrolled and randomly assigned to 2 different treatment regimes: group A (30 patients) treated with maximum androgenic blockage (MAB), and group B (30 patients) treated with bicalutamide 150mg. Each group was divided in 2 subgroups A1–A2 and B1–B2. All patients received calcium and cholecalciferol supplements …

Neuromuscular Performance and Hormonal Profile During Military Training and Subsequent Recovery Period.

2018

INTRODUCTION Military training loads may induce different physiological responses in garrison and field training and only a little is known about how short-time recovery, lasting a few days, affects neuromuscular fitness and hormonal profile. This study aimed to investigate the effects of garrison and field military service on neuromuscular performance and hormonal profile and to evaluate the effects of a 3-day recovery on those factors. METHODS Twenty healthy male soldiers (20 ± 1 years) participated in the study, which consisted of 4 days of garrison training [days (D) 1-4] and 7 days of military field training (Days 5-12) followed by a 3-day recovery period (Day 15). Serum hormone concen…

Contrasting parental roles shape sex differences in poison frog space use but not navigational performance

2022

Sex differences in vertebrate spatial abilities are typically interpreted under the adaptive specialization hypothesis, which posits that male reproductive success is linked to larger home ranges and better navigational skills. The androgen spillover hypothesis counters that enhanced male spatial performance may be a byproduct of higher androgen levels. Animal groups that include species where females are expected to outperform males based on life-history traits are key for disentangling these hypotheses. We investigated the association between sex differences in reproductive strategies, spatial behavior, and androgen levels in three species of poison frogs. We tracked individuals in natura…

Evolutionary psychology in marketing: Deep, debated, but fancier with fieldwork

2021

Can Digit Ratio and Gender Identity Predict Preferences for Consumption Options With a Distinct Gender Image?

2022

This study investigated whether individuals’ preferences for masculine (vs. feminine) consumption options could be predicted by a biological sex cue (the 2D:4D digit ratio; a biomarker linked to prenatal testosterone exposure), and a psychological gender cue (self-perceived gender identity). Chinese participants (N= 216) indicated their preferences for a series of binary options that differed in their perceived gender image (e.g., romantic comedy vs. action thriller; pop music vs. hard rock), with one of the options evaluated as relatively more feminine and the other viewed as comparably more masculine. Participants also self-reported their gender identity and the length of their index and …

Presentazione

2013

Characterization of cryopreserved rat liver parenchymal cells by metabolism of diagnostic substrates and activities of related enzymes

1992

The metabolism of testosterone and benzo(a)pyrene (BaP) which is mediated by diverse enzymes was determined in cryopreserved rat liver parenchymal cells and compared with that found in freshly isolated cells. In addition, the activities of single xenobiotic-metabolizing enzymes were measured by using specific substrates. The cytochrome P450 (P450)-mediated total metabolic conversion of testosterone was reduced to 55% in cryopreserved cells. The metabolite profile, i.e. the formation of single metabolites compared with total metabolic conversion, was however unchanged when compared with freshly isolated cells. A concomitant reduction in the activities of the involved P450 isoenzymes can ther…

La dimensione ambientale dell'intervento sul costruito

2019

Il saggio introduttivo tratteggia l'evoluzione dell'intervento sul costruito, che negli ultimi quarant’anni si è trasformato da operazione di nicchia, ai margini degli interessi culturali ed economici dominanti in un settore edilizio concentrato su nuove edificazioni, a fattore di traino del comparto, specialmente nell’ultimo decennio dominato da una crisi finanziaria che ha contribuito a ridimensionare le occasioni di costruzione ex novo. Considerando aperta la questione metodologica della ricerca di un approccio olistico, viene sottolineata l'importanza della conoscenza delle condizioni contestuali come premessa del progetto.

Le varianti d’autore in "Asterusher" di Michele Mari

2021

Nel 2019 Michele Mari pubblica una seconda edizione del fototesto Asterusher. Autobiografia per feticci, con l’aggiunta di sedici pagine. La riscrittura diventa innanzitutto una ricomposizione grafica e una nuova disposizione delle pagine, la cui sequenza si dimostra un ampliamento, grazie ad alcune necessarie integrazioni, oppure un’intensificazione di nuclei tematici, sviluppati soprattutto a partire dalle relazioni genitoriali che erano state al centro di Leggenda privata. Il contributo propone lo studio di alcune varianti d’autore e delle loro funzioni nell’archivio fototestuale autobiografico degli oggetti pregnanti di Michele Mari. In 2019 Michele Mari publishes a second edition of th…

Inducing properties of rifampicin and rifabutin for selected enzyme activities of the cytochrome P-450 and UDP-glucuronosyltransferase superfamilies …

1996

Important species differences have been reported concerning the induction properties of rifampicin towards enzymes of the P-450 superfamily. Mice, rabbits and humans are far more responsive than rats and guinea pigs. In the present study a strong induction of cytochrome P-450 3A-dependent enzyme activities was observed in female rat liver microsomes after high dose treatment (> or = 250 mg/kg/day for 9 days) with rifampicin, resulting in an up to 30-fold enhanced hydroxylation rate of testosterone in the 2 beta-, 6 beta- and 15 beta-position in vitro. Other cytochrome P-450 isozyme-selective reactions were not, or only marginally, affected. A steep increase in cytochrome P-450 3A activity o…