Search results for "Tetrachlorodecaoxide"
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Tetrachlorodecaoxide Improves the Oxygenation Status of Multicellular Tumor Spheroids
1986
Insufficient O2 supply to solid tumors has been recognized since many years to be a crucial problem in cancer therapy. Hypoxia and anoxia may increase the resistance of tumor cells to certain antiproliferative drugs or to ionizing radiation. Numerous approaches to overcoming this problem have been reported in the literature. Efforts have been made in mainly two basic directions: (1) the development of therapeutic means which are particularly efficient in hypoxic and nutrient-deprived tissue areas or which are at least independent of the tissue oxygenation, and (2) the development of methods for improving the oxygenation status of solid tumors. Among the former approaches, the cytotoxicity o…
Granulocyte Activity Is Enhanced by Culture Supernatants of Mononuclear Leukocytes Incubated with Tetrachlorodecaoxide
1995
Granulocytes (polymorphonuclear leukocytes, PMNs) and monocytes/ macrophages are important in wound healing. Within the first few hours PMNs and monocytes begin to infiltrate sites of injury. The major function of PMNs is to kill microbes and phagocytose cellular debris so that healing can proceed [1]. Monocytes/macrophages invading the wound are also active in phagocytosis. In addition they release a number of cytokines including growth factors, interleukin-8 (IL-8), and tumor necrosis factor (TNF-α) needed for new tissue formation and shown to stimulate PMNs [1–3].