6533b86dfe1ef96bd12c9377
RESEARCH PRODUCT
Granulocyte Activity Is Enhanced by Culture Supernatants of Mononuclear Leukocytes Incubated with Tetrachlorodecaoxide
R. E. SchopfG. A. HermannJ. HinzB. Morschessubject
medicine.anatomical_structureChemistryPhagocytosisTetrachlorodecaoxidemedicineCell culture supernatantTumor necrosis factor alphaGranulocyteWound healingCellular DebrisMicrobiologyRespiratory burstmedicine.drugdescription
Granulocytes (polymorphonuclear leukocytes, PMNs) and monocytes/ macrophages are important in wound healing. Within the first few hours PMNs and monocytes begin to infiltrate sites of injury. The major function of PMNs is to kill microbes and phagocytose cellular debris so that healing can proceed [1]. Monocytes/macrophages invading the wound are also active in phagocytosis. In addition they release a number of cytokines including growth factors, interleukin-8 (IL-8), and tumor necrosis factor (TNF-α) needed for new tissue formation and shown to stimulate PMNs [1–3].
year | journal | country | edition | language |
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1995-01-01 |