Search results for "Theria"
showing 10 items of 94 documents
Effect of priming with diphtheria and tetanus toxoids combined with whole-cell pertussis vaccine or with acellular pertussis vaccine on the safety an…
1995
Objective: To evaluate the safety and the immunogenicity of a booster dose of recombinant acellular pertussis vaccine combined with diphtheria and tetanus toxoids (DTaP, Biocine SpA) in 15- to 21-month-old children primed in infancy with either whole-cell diphtheria-tetanus-pertussis (DTwP) vaccine or DTaP vaccine. Design: Open-label second phase of a double-masked, controlled trail, with masked analysis of serum samples. Participants and setting: Three hundred fifty children, 15 to 21 months of age, who had been primed at 2, 4, and 6 months of age with either three doses of DTaP vaccine (n = 173) or DTwP vaccine (n = 177). The children were enrolled in eight vaccination centers in Italy. I…
D2R striatopallidal neurons inhibit both locomotor and drug reward processes.
2009
The specific functions of dopamine D(2) receptor-positive (D(2)R) striatopallidal neurons remain poorly understood. Using a genetic mouse model, we found that ablation of D(2)R neurons in the entire striatum induced hyperlocomotion, whereas ablation in the ventral striatum increased amphetamine conditioned place preference. Thus D(2)R striatopallidal neurons limit both locomotion and, unexpectedly, drug reinforcement.
Noetherian type in topological products
2010
The cardinal invariant "Noetherian type" of a topological space $X$ (Nt(X)) was introduced by Peregudov in 1997 to deal with base properties that were studied by the Russian School as early as 1976. We study its behavior in products and box-products of topological spaces. We prove in Section 2: 1) There are spaces $X$ and $Y$ such that $Nt(X \times Y) < \min\{Nt(X), Nt(Y)\}$. 2) In several classes of compact spaces, the Noetherian type is preserved by the operations of forming a square and of passing to a dense subspace. The Noetherian type of the Cantor Cube of weight $\aleph_\omega$ with the countable box topology, $(2^{\aleph_\omega})_\delta$, is shown in Section 3 to be closely related …
Impact of the recommendations on the vaccination of the tetanus–diphtheria in the labor area
2017
Abstract Objective Our aim is evaluate vaccination guidelines that were published by Ministry of Health of Spain and his impact in a mutual injuries work of Spain (FREMAP). Method Is a retrospective observational study of vaccination with tetanus–diphtheria (Td) in adults of mutual injuries of work of Spain (FREMAP) between January 2010 and December 2013. Results We have registered 126,101 injured employees for vaccination; of those have been vaccinated 11,468 (9%). We have not found significant differences in employees with incapacity or no. We have not found significant differences by sex. We have found significant differences by age group (46–55 years), women more than men (χ2 = 4.422; p…
Vaccines Through Centuries: Major Cornerstones of Global Health
2015
Multiple cornerstones have shaped the history of vaccines, which may contain live-attenuated viruses, inactivated organisms/viruses, inactivated toxins, or merely segments of the pathogen that could elicit an immune response. The story began with Hippocrates 400 B.C. with his description of mumps and diphtheria. No further discoveries were recorded until 1100 A.D. when the smallpox vaccine was described. During the eighteenth century, vaccines for cholera and yellow fever were reported and Edward Jenner, the father of vaccination and immunology, published his work on smallpox. The nineteenth century was a major landmark, with the "Germ Theory of disease" of Louis Pasteur, the discovery of t…
Booster vaccination after neonatal priming with acellular pertussis vaccine.
2010
After a birth dose of acellular pertussis (aP) and diphtheria (DT)aP-hepatitis B virus (HBV)-inactivated polio vaccine (IPV)/ Haemophilus influenza type b (Hib) at 2, 4, and 6 months, a booster dose of DTaP-HBV-IPV/Hib at 12 to 23 months induced strong anti-pertussis booster responses. Thus, neonatal aP priming did not lead to immune tolerance to pertussis antigens. However, it elicited bystander interference on HBV, Hib, and diphtheria responses.
L'arbre de la vie a-t-il une structure fractale?
1999
Abstract We analyse the time sequences of major evolutionary leaps at various scales, from the scale of the global tree of life, to the scales of orders and families such as sauropod dinosaurs, North American fossil Equidae, rodents, and primates including the Hominidae. In each case we find that these data are consistent with a log- periodic law to high level of statistical significance. Such a law is characterized by a critical epoch of convergence Tc specific to the lineage under consideration and that can be interpreted as the end of that lineage's capacity to evolve.
The Jaguar - Panthera onca gombaszoegensis (Kretzoi, 1938) (Carnivora: Felidae) in the late lower pleistocene of Akhalkalaki (south Georgia; Transcau…
2001
Abstract A lower hemimandibula of a pantherine cat of Akhalkalaki (south Georgia, Transcaucasia) is re-examinated. The fossil originates from lacustrine sediments of late Lower Pleistocene age (0.9 − 0.8 Ma B.P.) above the Jaramillo polarity subzone. A tooth-by-tooth analysis comparing the fossil with Lower and Middle Pleistocene lions, tigers and jaguars and Holocene southwest Asian lions assigns it to the Eurasian jaguar, Panthera onca gombaszoegensis. Palaeoenvironmental reconstruction indicates a dry, warm meadow-steppe influenced by montane condition, with permanent water bodies present. This is consistent with the strong open-water affinities of the modern jaguar. The morphological pr…
A Controlled Trial of Two Acellular Vaccines and One Whole-Cell Vaccine against Pertussis
1996
Background Concern about both safety and efficacy has made the use of whole-cell pertussis vaccines controversial. In some European countries, including Italy, the rate of vaccination against pertussis is low. Methods We conducted a double-blind trial in Italy in which infants were randomly assigned to vaccination at two, four, and six months of age with an acellular pertussis vaccine together with diphtheria and tetanus toxoids (DTP); a DTP vaccine containing whole-cell pertussis (manufactured by Connaught Laboratories); or diphtheria and tetanus toxoids without pertussis (DT). The acellular DTP vaccine was either one containing filamentous hemagglutinin, pertactin, and pertussis toxin ina…
Acute selective ablation of rat insulin promoter-expressing (RIP HER ) neurons defines their orexigenic nature
2012
Rat insulin promoter (RIP)-expressing neurons in the hypothalamus control body weight and energy homeostasis. However, genetic approaches to study the role of these neurons have been limited by the fact that RIP expression is predominantly found in pancreatic β-cells, which impedes selective targeting of neurons. To define the function of hypothalamic RIP-expressing neurons, we set out to acutely and selectively eliminate them via diphtheria toxin-mediated ablation. Therefore, the diphtheria toxin receptor transgene was specifically expressed upon RIP-specific Cre recombination using a RIP-Cre line first described by Herrera (RIP HER -Cre) [Herrera PL (2000) Development 127:2317–2322]. Usi…