Search results for "Throughput"
showing 10 items of 483 documents
An analytical model of a new packet marking algorithm for TCP flows
2005
In Differentiated Services networks, packets may receive a different treatment according to their Differentiateo Services Code Point (DSCP) label. As a consequence, packet marking schemes can also be devised to differentiate packets belonging to a same TCP flow, with the goal of improving the performance experienced. This paper presents an analytical model for an adaptive packet marking scheme proposed in our previous work. The model combines three specific sub-models aimed at describing (i) the TCP sources aggregate, (ii) the marker, and (iii) the network status. Preliminary simulation results show quite accurate predictions for throughput and average queue occupancy. Besides, the research…
Whole genome sequencing of the black grouse (Tetrao tetrix): reference guided assembly suggests faster-Z and MHC evolution
2014
Background The different regions of a genome do not evolve at the same rate. For example, comparative genomic studies have suggested that the sex chromosomes and the regions harbouring the immune defence genes in the Major Histocompatability Complex (MHC) may evolve faster than other genomic regions. The advent of the next generation sequencing technologies has made it possible to study which genomic regions are evolutionary liable to change and which are static, as well as enabling an increasing number of genome studies of non-model species. However, de novo sequencing of the whole genome of an organism remains non-trivial. In this study, we present the draft genome of the black grouse, wh…
Discovery and validation of small-molecule heat-shock protein 90 inhibitors through multimodality molecular imaging in living subjects.
2012
Up-regulation of the folding machinery of the heat-shock protein 90 (Hsp90) chaperone protein is crucial for cancer progression. The two Hsp90 isoforms (α and β) play different roles in response to chemotherapy. To identify isoform-selective inhibitors of Hsp90(α/β)/cochaperone p23 interactions, we developed a dual-luciferase (Renilla and Firefly) reporter system for high-throughput screening (HTS) and monitoring the efficacy of Hsp90 inhibitors in cell culture and live mice. HTS of a 30,176 small-molecule chemical library in cell culture identified a compound, N -(5-methylisoxazol-3-yl)-2-[4-(thiophen-2-yl)-6-(trifluoromethyl)pyrimidin-2-ylthio]acetamide (CP9), that binds to Hsp90(α/β) an…
Unveiling distribution patterns of freshwater phytoplankton by a next generation sequencing based approach.
2012
The recognition and discrimination of phytoplankton species is one of the foundations of freshwater biodiversity research and environmental monitoring. This step is frequently a bottleneck in the analytical chain from sampling to data analysis and subsequent environmental status evaluation. Here we present phytoplankton diversity data from 49 lakes including three seasonal surveys assessed by next generation sequencing (NGS) of 16S ribosomal RNA chloroplast and cyanobacterial gene amplicons and also compare part of these datasets with identification based on morphology. Direct comparison of NGS to microscopic data from three time-series showed that NGS was able to capture the seasonality in…
High-throughput sequencing of RNA silencing-associated small RNAs in olive (Olea europaea L.).
2011
14 páginas, 5 figuras, 3 tablas, S4 figuras, S2 tablas
Measuring RNA polymerase activity genome-wide with high-resolution run-on-based methods
2019
The biogenesis of RNAs is a multi-layered and highly regulated process that involves a diverse set of players acting in an orchestrated manner throughout the transcription cycle. Transcription initiation, elongation and termination factors act on RNA polymerases to modulate their movement along the DNA template in a very precise manner, more complex than previously anticipated. Genome-scale run-on-based methodologies have been developed to study in detail the position of transcriptionally-engaged RNA polymerases. Genomic run-on (GRO), and its many variants and refinements made over the years, are helping the community to address an increasing amount of scientific questions, spanning an incr…
Evolution of common ragweed (Ambrosia artemisiifolia) resistance to herbicides : identification of genetic determinisms and application to molecular …
2022
Common ragweed (Ambrosia artemisiifolia L.), a particularly troublesome and allergenic weed, is mainly controlled in agricultural fields using ALS inhibitor herbicides. Recent cases of herbicide resistance have been reported in France and are jeopardising the efficacy of this mode of action. Both target site resistance (TSR, structural mutation in ALS gene) and non target site resistance (NTSR, regulatory and/or structural mutations in secondary metabolism) are involved. The fundamental aim of this work was to identify the genetic determinisms of resistance to ALS inhibitors that have evolved in common ragweed populations in France. As an applied objective, this work also aimed to prepare t…
Increasing the performance of HSDPA with high-speed single frequency network
2012
High Speed Single Frequency Network (HS-SFN) is a multi-cell transmission scheme for High-Speed Downlink Packet Access (HSDPA) that can assist user equipment (UEs) in the softer handover area by combining signals from two neighbouring cells and at the same time by reducing the inter-cell interference. This article analyzes performance of HS-SFN for macro cell scenario under different channels with different type of schedulers by means of extensive system level simulations. The results indicate that HS-SFN can increase throughput for UEs in softer handover area from 40% to 80% without decreasing the overall performance.
Non-regular network performance comparison between HSDPA and LTE
2010
In this paper we study and benchmark the performance of 3rd Generation Partnership Project (3GPP) High Speed Downlink Packet Access (HSDPA) and 3GPP Long Term Evolution (LTE) Downlink with constant bit rate type traffic. In addition a non-regular simulation scenario is considered using realistic propagation data and base station positions related to Tokyo city downtown area. HSDPA was introduced in 3GPP Release 5 and in further releases the technology has been improved with e.g. receive and transmit diversity technologies and support for higher order modulation schemes. LTE was introduced in 3GPP Release 8 with completely new physical layer and improved Radio Resource Management (RRM) funct…
Identification and optimization of small molecule antagonists of vasoactive intestinal peptide receptor-1 (VIPR1).
2012
Identification, synthesis and structure-activity relationship of small-molecule VIPR1 antagonists encompassing two chemical series are described.