Search results for "Tia"

showing 10 items of 23399 documents

Adventiv-Embryonen aus Nicotiana-kallus, der bei Hohen Lichtintensitäten Kultiviert wurde

1965

The formation of embryonic structures in Nicotiana callus tissue has been reported. High intensity of light as a stimulating factor in differentiation is discussed.

virusesEmbryonic StructureCallusHigh intensityfungiBotanyGeneticsfood and beveragesPlant ScienceBiologymusculoskeletal systembiology.organism_classificationNicotianaPlanta
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Single-chain antibodies against a plant viral RNA-dependent RNA polymerase confer virus resistance.

2004

Crop loss due to viral diseases is still a major problem for agriculture today. We present a strategy to achieve virus resistance based on the expression of single-chain Fv fragments (scFvs) against a conserved domain in a plant viral RNA-dependent RNA polymerase (RdRp), a key enzyme in virus replication. The selected scFvs inhibited complementary RNA synthesis of different plant virus RdRps in vitro and virus replication in planta. Moreover, the scFvs also bound to the RdRp of the distantly related hepatitis C virus. T(1) and T(2) progeny of transgenic lines of Nicotiana benthamiana expressing different scFvs either in the cytosol or in the endoplasmic reticulum showed varying degrees of r…

virusesHepatitis C virusAmino Acid MotifsBiomedical EngineeringNicotiana benthamianaBioengineeringmedicine.disease_causeAntibodies ViralVirus ReplicationApplied Microbiology and BiotechnologyVirusPlant VirusesTombusviruschemistry.chemical_compoundRNA polymerasePlant virusTobaccomedicinePlant DiseasesGeneticsbiologyfungifood and beveragesbiology.organism_classificationPlants Genetically ModifiedRNA-Dependent RNA PolymeraseVirologyTombusviridaechemistryViral replicationMolecular MedicineSingle-Chain AntibodiesBiotechnologyNature biotechnology
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The Extracellular δ-Domain is Essential for the Formation of CD81 Tetraspanin Webs

2014

AbstractCD81 is a ubiquitously expressed member of the tetraspanin family. It forms large molecular platforms, so-called tetraspanin webs that play physiological roles in a variety of cellular functions and are involved in viral and parasite infections. We have investigated which part of the CD81 molecule is required for the formation of domains in the cell membranes of T-cells and hepatocytes. Surprisingly, we find that large CD81 platforms assemble via the short extracellular δ-domain, independent from a strong primary partner binding and from weak interactions mediated by palmitoylation. The δ-domain is also essential for the platforms to function during viral entry. We propose that, ins…

virusesLipoylationBiophysicschemical and pharmacologic phenomenaPlasma protein bindingBiologyTetraspanin 28Jurkat CellsProtein structurePalmitoylationTetraspaninViral entryExtracellularHumansComputingMilieux_MISCELLANEOUS[PHYS]Physics [physics]MembranesHep G2 Cellsbiochemical phenomena metabolism and nutritionCell biologyProtein Structure TertiaryProtein MultimerizationProtein Processing Post-TranslationalFunction (biology)CD81Protein Binding
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A Perturbed Cauchy Viscoelastic Problem in an Exterior Domain

2023

A Cauchy viscoelastic problem perturbed by an inverse-square potential, and posed in an exterior domain of RN, is considered under a Dirichlet boundary condition. Using nonlinear capacity estimates specifically adapted to the non-local nature of the problem, the potential function and the boundary condition, we establish sufficient conditions for the nonexistence of weak solutions.

viscoelastic problem; hardy potential; exterior domain; nonexistencenonexistenceSettore MAT/05 - Analisi MatematicaGeneral MathematicsComputer Science (miscellaneous)hardy potentialexterior domainEngineering (miscellaneous)viscoelastic problem
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Game-Theoretic Approach to Hölder Regularity for PDEs Involving Eigenvalues of the Hessian

2021

AbstractWe prove a local Hölder estimate for any exponent $0<\delta <\frac {1}{2}$ 0 < δ < 1 2 for solutions of the dynamic programming principle $$ \begin{array}{@{}rcl@{}} u^{\varepsilon} (x) = \sum\limits_{j=1}^{n} \alpha_{j} \underset{\dim(S)=j}{\inf} \underset{|v|=1}{\underset{v\in S}{\sup}} \frac{u^{\varepsilon} (x + \varepsilon v) + u^{\varepsilon} (x - \varepsilon v)}{2} \end{array} $$ u ε ( x ) = ∑ j = 1 n α j inf dim ( S ) = j sup v ∈ S | v | = 1 u ε ( x + ε v ) + u ε ( x − ε v ) 2 with α1,αn > 0 and α2,⋯ ,αn− 1 ≥ 0. The proof is based on a new coupling idea from game theory. As an application, we get the same regularity estimate for viscosity solutions of the PDE $…

viscosity solutionosittaisdifferentiaaliyhtälötMathematics::Functional AnalysisStatistics::Theory91A05 91A15 35D40 35B65Mathematics::Dynamical Systemsholder estimateMathematics::Analysis of PDEsmatemaattinen optimointifully nonlinear PDEsdynamic programming principleMathematics - Analysis of PDEsMathematics::ProbabilityFOS: Mathematicspeliteoriaeigenvalue of the HessianAnalysisAnalysis of PDEs (math.AP)estimointi
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Equivalence of viscosity and weak solutions for a $p$-parabolic equation

2019

AbstractWe study the relationship of viscosity and weak solutions to the equation $$\begin{aligned} \smash {\partial _{t}u-\varDelta _{p}u=f(Du)}, \end{aligned}$$ ∂ t u - Δ p u = f ( D u ) , where $$p>1$$ p > 1 and $$f\in C({\mathbb {R}}^{N})$$ f ∈ C ( R N ) satisfies suitable assumptions. Our main result is that bounded viscosity supersolutions coincide with bounded lower semicontinuous weak supersolutions. Moreover, we prove the lower semicontinuity of weak supersolutions when $$p\ge 2$$ p ≥ 2 .

viscosity solutionosittaisdifferentiaaliyhtälötPure mathematics35K92 35J60 35D40 35D30 35B51Mathematics::Analysis of PDEscomparison principleweak solutionparabolic p-LaplacianViscosityMathematics (miscellaneous)Mathematics - Analysis of PDEsBounded functionFOS: Mathematicsgradient termEquivalence (measure theory)MathematicsAnalysis of PDEs (math.AP)
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Hölder gradient regularity for the inhomogeneous normalized p(x)-Laplace equation

2022

We prove the local gradient Hölder regularity of viscosity solutions to the inhomogeneous normalized p(x)-Laplace equation −Δp(x)Nu=f(x), where p is Lipschitz continuous, inf⁡p>1, and f is continuous and bounded. peerReviewed

viscosity solutionosittaisdifferentiaaliyhtälötnon-divergence form equationHölder gradient regularityinhomogeneous equationApplied Mathematicsnormalized equationp-LaplaceAnalysisJournal of Mathematical Analysis and Applications
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Regularity for nonlinear stochastic games

2015

We establish regularity for functions satisfying a dynamic programming equation, which may arise for example from stochastic games or discretization schemes. Our results can also be utilized in obtaining regularity and existence results for the corresponding partial differential equations. peerReviewed

viscosity solutionsDiscretization01 natural sciencesMathematics - Analysis of PDEsBellman equationComputingMethodologies_SYMBOLICANDALGEBRAICMANIPULATIONFOS: MathematicsApplied mathematicstug-of-war0101 mathematicsMathematics - Optimization and ControlMathematical PhysicsMathematicsstokastiset prosessitPartial differential equationApplied Mathematics91A15 35J92 35B65 35J60 49N60010102 general mathematicsta111dynamic programming principletug-of-war with noise with space dependent probabilities010101 applied mathematicsNonlinear systemOptimization and Control (math.OC)p-LaplaceAnalysisAnalysis of PDEs (math.AP)
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Remarks on regularity for p-Laplacian type equations in non-divergence form

2018

We study a singular or degenerate equation in non-divergence form modeled by the $p$-Laplacian, $$-|Du|^\gamma\left(\Delta u+(p-2)\Delta_\infty^N u\right)=f\ \ \ \ \text{in}\ \ \ \Omega.$$ We investigate local $C^{1,\alpha}$ regularity of viscosity solutions in the full range $\gamma>-1$ and $p>1$, and provide local $W^{2,2}$ estimates in the restricted cases where $p$ is close to 2 and $\gamma$ is close to 0.

viscosity solutionsintegrability of second derivativesType (model theory)01 natural sciencesDivergencelocal C1ViscosityMathematics - Analysis of PDEsFOS: Mathematicspartial differential equations0101 mathematicsMathematicsMathematical physicsosittaisdifferentiaaliyhtälötα regularityApplied Mathematics010102 general mathematicsta111p-Laplacianlocal C1α regularityviskositeettiDegenerate equation35J60 35B65 35J92010101 applied mathematicsviscosityp-LaplacianAnalysisAnalysis of PDEs (math.AP)Journal of Differential Equations
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(A,B) In vivo GCaMP6f signals recorded in layers M1, M5 and M9/10 of Mi1 (A) and Tm3 (B) neurons, before (blue, green) and after (gray, red) applicat…

2019

Sensory systems sequentially extract increasingly complex features. ON and OFF pathways, for example, encode increases or decreases of a stimulus from a common input. This ON/OFF pathway split is thought to occur at individual synaptic connections through a sign-inverting synapse in one of the pathways. Here, we show that ON selectivity is a multisynaptic process in the Drosophila visual system. A pharmacogenetics approach demonstrates that both glutamatergic inhibition through GluClα and GABAergic inhibition through Rdl mediate ON responses. Although neurons postsynaptic to the glutamatergic ON pathway input L1 lose all responses in GluClα mutants, they are resistant to a cell-type-specifi…

visionQH301-705.5GABA AgentsScienceModels Neurological610Sensory systemBiologyStimulus (physiology)distributed codingGeneral Biochemistry Genetics and Molecular BiologySynapseglutamatergic inhibition03 medical and health sciencesGlutamatergic0302 clinical medicinePostsynaptic potentialOff pathwayInterneuronsAnimalsVisual PathwaysExcitatory Amino Acid AgentsBiology (General)030304 developmental biology0303 health sciencesGeneral Immunology and MicrobiologyGABAergic inhibitionD. melanogasterON selectivityGeneral Neurosciencefeature extractionQRGeneral MedicineD. melanogaster; GABAergic inhibition; ON selectivity; distributed coding; feature extraction; glutamatergic inhibition; neuroscience; visionVisual PerceptionMedicineGabaergic inhibitionDrosophilaSelectivityNeuroscience030217 neurology & neurosurgeryResearch ArticleNeuroscience
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