Search results for "Timo"
showing 10 items of 2111 documents
Preoperative Radiochemotherapy and Radical Surgery of Advanced Head and Neck Cancers — Results of a Prospective, Multicenter DÖSAK Study
1994
Present research concerning the efficiacy of therapeutic strategies for squamous cell carcinomas of the oral cavity and the oropharynx profits from former observational studies. The so-called retrospective German, Austrian, and Swiss Association for Head and Neck Tumors (DOSAK) study (Platz et al. 1986) served to review existing proposals for classification (UICC 1973, 1978; AJC 1978) and to develop a statistical classification which enables the head and neck oncologist to define prognostically homogeneous patient collectives. The treatment-dependent prognostic index (TPI) was the corresponding result (Platz et al. 1982).
Central Nervous System Malignancies
2021
The primitive neoplasms of the central nervous system (CNS) are a rare and heterogeneous group of malignancies. Brain metastases (BMs) are the most frequent intracranial tumor, and their incidence is rising in the last few decades. Primary tumors more often complicated by BMs are lung cancer, breast cancer, and melanoma. Neuroimaging techniques, mainly magnetic resonance imaging (MRI), play a key role for the diagnosis of BMs. The management of BMs is based on a multimodal approach, including symptomatic treatment, local treatment, such as surgery, stereotactic radiosurgery (SRS), and whole brain radiotherapy (WBRT), and systemic therapy, such as chemotherapy, target therapy, or immunothera…
Systemic chemotherapy and pressurized intraperitoneal aerosol chemotherapy (PIPAC): A case report of a multimodal treatment for peritoneal metastases…
2020
Highlights • Integration of PIPAC to systemic chemotherapy can have good tolerance profile. • Repeated biopsies performed during PIPAC allowed therapy-response monitoring. • Analysis of biopsies performed during PIPAC allowed tailoring of chemotherapy. • Integration of PIPAC to systemic chemotherapy can permit good quality of life.
A Computationally Inexpensive Approach in Multiobjective Heat Exchanger Network Synthesis
2010
We consider a heat exchanger network synthesis problem formulated as a multiobjective optimization problem. The Pareto front of this problem is approximated with a new approximation approach and the preferred point on the approximation is found with the interactive multiobjective optimization method NIMBUS. Using the approximation makes the solution process computationally inexpensive. Finally, the preferred outcome on the Pareto front approximation is projected on the actual Pareto front. peerReviewed
Highly efficient few-mode spatial beam self-cleaning at 15µm
2020
We experimentally demonstrate that spatial beam self-cleaning can be highly efficient when obtained with a few-mode excitation in graded-index multimode optical fibers. By using 160 ps long, highly chirped (6 nm bandwidth at -3dB) optical pulses at 1562 nm, we demonstrate a one-decade reduction of the power threshold for spatial beam self-cleaning, with respect to previous experiments using pulses with laser wavelengths at 1030-1064 nm. Self-cleaned beams remain spatio-temporally stable for more than a decade of their peak power variation. The impact of input pulse temporal duration is also studied.
Existence for shape optimization problems in arbitrary dimension
2002
We discuss some existence results for optimal design problems governed by second order elliptic equations with the homogeneous Neumann boundary conditions or with the interior transmission conditions. We show that our continuity hypotheses for the unknown boundaries yield the compactness of the associated characteristic functions, which, in turn, guarantees convergence of any minimizing sequences for the first problem. In the second case, weaker assumptions of measurability type are shown to be sufficient for the existence of the optimal material distribution. We impose no restriction on the dimension of the underlying Euclidean space.
Fixed domain approaches in shape optimization problems with Dirichlet boundary conditions
2009
Fixed domain methods have well-known advantages in the solution of variable domain problems including inverse interface problems. This paper examines two new control approaches to optimal design problems governed by general elliptic boundary value problems with Dirichlet boundary conditions. Numerical experiments are also included peerReviewed
Joint Power Allocation and Link Selection for Multi-Carrier Buffer Aided Relay Network
2019
In this paper, we present a joint power allocation and adaptive link selection protocol for an orthogonal frequency division multiplexing (OFDM)-based network consists of one source node i.e., base station (BS), one destination node i.e., (MU) and a buffer aided decode and forward (DF) relay node. Our objective is to maximize the average throughput of the system via power loading over different subcarriers at source and relay nodes. A separate power budget is assumed at each transmitting node to make the system more practical. In order to form our solution more tractable, a decomposition framework is implemented to solve the mixed integer optimization problem. Further, less complex suboptim…
Guaranteed lower bounds for cost functionals of time-periodic parabolic optimization problems
2019
In this paper, a new technique is shown for deriving computable, guaranteed lower bounds of functional type (minorants) for two different cost functionals subject to a parabolic time-periodic boundary value problem. Together with previous results on upper bounds (majorants) for one of the cost functionals, both minorants and majorants lead to two-sided estimates of functional type for the optimal control problem. Both upper and lower bounds are derived for the second new cost functional subject to the same parabolic PDE-constraints, but where the target is a desired gradient. The time-periodic optimal control problems are discretized by the multiharmonic finite element method leading to lar…
Forest management optimization across spatial scales to reconcile economic and conservation objectives
2019
Conflicts between biodiversity conservation and resource production can be mitigated by multi-objective management planning. Optimizing management for multiple objectives over larger land areas likely entails trading off the practicability of the process against the goodness of the solution. It is therefore worthwhile to resolve how large areas are required as management planning regions to reconcile conflicting objectives as effectively as possible. We aimed to reveal how the extent of forestry planning regions impacts the potential to mitigate a forestry-conservation conflict in Finland, represented as a trade-off between harvest income and deadwood availability. We used forecasted data f…