Search results for "Tipa"

showing 10 items of 596 documents

Synthesis and biological evaluation of papain-family cathepsin L-like cysteine protease inhibitors containing a 1,4-benzodiazepine scaffold as antipr…

2014

Novel papain-family cathepsin L-like cysteine protease inhibitors endowed with antitrypanosomal and antimalarial activity were developed, through an optimization study of previously developed inhibitors. In the present work, we studied the structure-activity relationships of these derivatives, with the aim to develop new analogues with a simplified and more synthetically accessible structure and with improved antiparasitic activity. The structure of the model compounds was significantly simplified by modifying or even eliminating the side chain appended at the C3 atom of the benzodiazepine scaffold. In addition, a simple methylene spacer of appropriate length was inserted between the benzod…

Trypanosomamedicine.drug_classPeptidomimeticStereochemistryAntiparasiticCell SurvivalCathepsin LAntiprotozoal AgentsCysteine Proteinase InhibitorsBiochemistryCathepsin BCell LineCathepsin Lchemistry.chemical_compoundBenzodiazepinesMiceStructure-Activity RelationshipDrug DiscoverymedicineMoietyAnimalsGeneral Pharmacology Toxicology and PharmaceuticsPharmacologyCathepsinbiologyOrganic ChemistryCombinatorial chemistryCysteine proteasePapainantiprotozoal agents; inhibitors; Malaria; Peptidomimetics; structure-activity relationshipsCysteine EndopeptidaseschemistryAntiprotozoalbiology.proteinMolecular MedicineProtein BindingChemMedChem
researchProduct

1. tipa cukura diabēta pacientu aprūpes process

2022

Bakalaura darba tēma: 1. tipa cukura diabēta pacientu aprūpes process. Tēmas aktualitāte ir tāda, ka CD ir globāla veselības problēma, kas ievērojami paaugstina slimīgumu un mirstību galvenokārt ielaisto CD komplikāciju (kardiovaskulārās slimības, acu un nieru slimības un ekstremitāšu amputācijas) attīstības dēļ. Darba mērķis: Noskaidrot 1. tipa cukura diabēta pacientu aprūpes procesu. Pētījuma jautājums: Kā tiek realizēts aprūpes process pacientiem ar 1. tipa cukura diabētu? Pētniecības metode: Kvalitatīvā pētniecības metode. Pētījuma instruments: Intervija. Bakalaura darba mērķis tika sasniegts un pētījuma jautājumā noskaidrojās, ka pacienti ir apzinīgi un zinoši par slimības īpatnībām, k…

Type 1 diabetesinsulīna injekcijas1. tipa cukura diabētscare processaprūpes processMedicīna
researchProduct

Adaptation of young teachers at school

2006

Straipsnyje aptariama, kaip Baltijos šalių mokyklose įgyvendinamas (2004–2007) Latvijos mokslo tarybos parengtas jaunųjų mokytojų adaptacijos projektas pirmaisiais darbo metais. Tyrimo dalyviai – 362 Rygos (Latvija), Klaipėdos (Lietuva) ir keturių Latvijos rajonų mokytojai, aukštąsias pedagogines mokyklas baigę 1995–2004 metais. Straipsnyje pateikiami mokslinio tyrimo rezultatai, rodantys mokytojų adaptaciją mokykloje skatinančius ir jai trukdančius veiksnius, vertinamas jaunųjų mokytojų psichologinis pasirengimas dirbti mokykloje. Respondentų teigimu, aukštosiose mokyklose apie pedagoginį darbą teikiama informacija yra objektyvi, jaunieji mokytojai jau pirmaisiais darbo metais sėkmingai ad…

Types of adaptationAdaptacijos veiksniaiAdaptacijaTipaiMokytojų ugdymas / Teacher educationVeiksniaiFactorsFactors of adaptationAdaptation of teachersYoung teachersTypesAdaptacijų tipaiAdaptationJauni mokytojai
researchProduct

The General Antiparticle Spectrometer (GAPS) - Hunt for dark matter using low energy antideuterons

2011

The GAPS experiment is foreseen to carry out a dark matter search using a novel detection approach to detect low-energy cosmic-ray antideuterons. The theoretically predicted antideuteron flux resulting from secondary interactions of primary cosmic rays with the interstellar medium is very low. So far not a single cosmic antideuteron has been detected by any experiment, but well-motivated theories beyond the standard model of particle physics, e.g., supersymmetry or universal extra dimensions, contain viable dark matter candidates, which could led to a significant enhancement of the antideuteron flux due to self-annihilation of the dark matter particles. This flux contribution is believed to…

Universal extra dimensionNuclear physicsInterstellar mediumPhysicsAntiparticleAnnihilationPhysics beyond the Standard ModelDark matterCosmic rayExotic atomProceedings of Identification of Dark Matter 2010 — PoS(IDM2010)
researchProduct

VESICAL IMAGING-REPORTING AND DATA SYSTEM – A NEW APPROACH TO BLADDER CANCER STAGING

2022

The aim: To present the assumptions and to show the usefulness of Vesical Imaging-Reporting and Data System (VI-RADS) based on multiparametric magnetic resonance imaging (mpMRI) in the diagnostic pathway management of patients with a bladder cancer. Materials and methods: The review is based on available literature from last 10 years from PubMed database and the Przegląd Urologiczny journal focusing on articles on VI-RADS. Overall, 18 articles were included. Presented magnetic resonance images come from the examinations of the patients who were diagnosed with bladder cancer from 2019 to 2021 at Department of Diagnostic Imaging in University Clinical Hospital in Opole, Poland. Conclusions: T…

Urinary Bladder Neoplasmsreference standardsUrinary BladderData SystemsHumansdiffusion-weighted magnetic resonance imagingProspective StudiesGeneral Medicinemultiparametric magnetic resonance imagingMagnetic Resonance ImagingNeoplasm StagingWiadomości Lekarskie
researchProduct

Performance Analysis of Alamouti Coded OFDM Systems over Rayleigh Fading Channels Correlated in Space and Time

2010

Paper presented at the 2010 IEEE 71st Vehicular Technology Conference, Taipei.(c) 2010 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other users, including reprinting/ republishing this material for advertising or promotional purposes, creating new collective works for resale or redistribution to servers or lists, or reuse of any copyrighted components of this work in other works. Paper also available from the publisher: http://dx.doi.org/10.1109/VETECS.2010.5493855 This paper deals with the performance analysis of Alamouti coded orthogonal frequency division multiplexing (OFDM) systems over time-varying multipath Rayleigh fading channels. I…

VDP::Mathematics and natural science: 400::Information and communication science: 420::Communication and distributed systems: 423Multipath rayleigh fading channelComputer scienceOrthogonal frequency-division multiplexingData_CODINGANDINFORMATIONTHEORYSpace (mathematics)Expression (mathematics)Signal-to-noise ratioVDP::Technology: 500::Information and communication technology: 550::Telecommunication: 552Computer Science::Networking and Internet ArchitectureElectronic engineeringFadingAlgorithmComputer Science::Information TheoryRayleigh fadingCommunication channel
researchProduct

SIA "Kalnciema ezītis" e-komercijas un interneta mārketinga iespējas

2019

Diplomdarba autors: Roberts Liepiņš Darba tēma: SIA “Kalnciema ezītis” e-komercijas un interneta mārketinga iespējas Darba mērķis: Izpētīt uzņēmuma SIA “Kalnciema ezītis” e-komercijas un interneta mārketinga iespējas un piedāvāt risinājumus uzņēmuma turpmākai attīstībai e-komercijas jomā. Darbs atspoguļo e-komercijas nozīmes pieaugumu un arvien augošo pieprasījumu no patērētājiem – veikt produktu un pakalpojumu iegādāšanos tiešsaistē. Taču Latvijā uzņēmēji neizmanto sniegtās iespējas pārdot produktus internetā, zaudējot potenciālo peļņu. Lai sasniegtu darba mērķi, autors izpētīja uzņēmuma pašreizējo situāciju attiecībā uz interneta iespēju lietošanu biznesā, analizēja un salīdzināja SIA “Ka…

VadībzinātneInterneta mārketingsmājaslapars prototipa izstrādemārketinga aktivitāšu plānsTiešsaites tirdzniecībae-komercija
researchProduct

Velocity estimation in wideband mobile stations equipped with multiple antennas

2009

©2009 IEEE. Personal use of this material is permitted. However, permission to reprint/republish this material for advertising or promotional purposes or for creating new collective works for resale or redistribution to servers or lists, or to reuse any copyrighted component of this work in other works must be obtained from the IEEE. Article also available from publisher: http://dx.doi.org/10.1109/VETECS.2009.5073907 A new method is proposed for estimating the velocity of wideband mobile stations (MSs) equipped with multiple antennas. The MS speed is determined using the well-known relationship between the direction-of-arrivals (DOAs) and the Doppler frequency shifts experienced by the mult…

Velocity estimationComputer scienceReal-time computingInterval (mathematics)Signalsymbols.namesakeSignal-to-noise ratioVDP::Technology: 500::Information and communication technology: 550::Telecommunication: 552symbolsWidebandAlgorithmDoppler effectMultipath propagationComputer Science::Information Theory
researchProduct

Didáctica (lengua y literatura)

2017

La diversidad siempre ha estado presente en nuestro alumnado, no obstante, la incorporación de culturas poco presentes en España, fue un revulsivo en los años 90 para la revitalización de la educación intercultural. Pero a nuestro parecer, existe una carencia importante de estudios acerca de cómo esta nueva multiculturalidad ha hecho mella en la sociedad, y en especial en los materiales no curriculares entre los cuales la Literatura Infantil y Juvenil (LIJ) es un componente fundamental. Es importante, pues, y necesario comprobar qué tratamiento se ha hecho de la multiculturalidad en la LIJ y el estereotipo es, sin duda, uno de los aspectos más sensibles que se reflejan en las obras.Nuestro …

What treatmentmedia_common.quotation_subjectliteratura infantil y juvenilestereotipoeducación inter-culturalLiterary Education.Literatura infantil y juvenil en catalán; Estereotipación; Multiculturalidad;Educación Intercultural; Educación Literaria.Literatura infantil y juvenil en catalánlengua catalanaSelection (linguistics)Sociologypercepción del otromedia_commonStereotypingInterculturalityGender studiesIntercultural EducationEducación Literaria.language.human_languageMulticulturalismMulticulturalismChildren’s and Young People Literature in Catalan languagelanguageEducación InterculturalCatalanEstereotipaciónDiversity (politics)Multiculturalidad
researchProduct

Simultaneous ranging and self-positioning in unsynchronized wireless acoustic sensor networks

2016

Automatic ranging and self-positioning is a very desirable property in wireless acoustic sensor networks, where nodes have at least one microphone and one loudspeaker. However, due to environmental noise, interference, and multipath effects, audio-based ranging is a challenging task. This paper presents a fast ranging and positioning strategy that makes use of the correlation properties of pseudonoise sequences for estimating simultaneously relative time-of-arrivals from multiple acoustic nodes. To this end, a proper test signal design adapted to the acoustic node transducers is proposed. In addition, a novel self-interference reduction method and a peak matching algorithm are introduced, a…

Wireless acoustic sensor networksMicrophoneComputer scienceReal-time computing02 engineering and technologyInterference (wave propagation)SynchronizationlocalizationTECNOLOGIA ELECTRONICA0202 electrical engineering electronic engineering information engineeringWirelessElectrical and Electronic Engineeringwireless acoustic sensor networksbusiness.industryRangingNode (networking)020208 electrical & electronic engineeringpseudo-noise seequences020206 networking & telecommunicationsRangingTransducerComputer Science::SoundEmbedded systemLocalizationSignal ProcessingLoudspeakerbusinessPseudo-noise seequencesMultipath propagation
researchProduct