Search results for "ToF"
showing 10 items of 841 documents
Historischer Überblick zur mathematischen Theorie von Unstetigkeitswellen seit Riemann und Christoffel
1981
We give a brief historical account of the development of the mathematical theory of propagation of discontinuities in gases, fluids or elastic materials. The theory was initiated by Riemann who investigated the propagation of shocks in one-dimensional isentropic gas flow. Riemann’s results were used by Christoffel to treat, more generally, the propagation of (first order) discontinuity surfaces in three-dimensional flows of perfect fluids. Subsequently Christoffel applied his general theory to first order waves in certain elastic materials. Independently of Riemann and Christoffel significant contributions were made by Hugoniot. The theory was completed in Hadamard’s celebrated monograph [3…
The Riemannian manifold of all Riemannian metrics
1991
In this paper we study the geometry of (M, G) by using the ideas developed in [Michor, 1980]. With that differentiable structure on M it is possible to use variational principles and so we start in section 2 by computing geodesics as the curves in M minimizing the energy functional. From the geodesic equation, the covariant derivative of the Levi-Civita connection can be obtained, and that provides a direct method for computing the curvature of the manifold. Christoffel symbol and curvature turn out to be pointwise in M and so, although the mappings involved in the definition of the Ricci tensor and the scalar curvature have no trace, in our case we can define the concepts of ”Ricci like cu…
Efficacy of short-term psychotherapy for multiple medically unexplained physical symptoms: a meta-analysis.
2011
Multiple medically unexplained physical symptoms (MUPS) are considered to be difficult and costly to treat. The current meta-analysis therefore investigates the efficacy of short-term psychotherapy for MUPS. Based on a multiple-phase literature search, studies were selected according to a-priori defined inclusion criteria. The standardized mean gain was used as the effect size index. Separate data aggregation of between- and within-group contrasts was performed on the basis of a mixed effects model. Outcome variables were physical symptoms, disorder specific emotions, cognitions and behaviors, depressive symptoms, general psychopathology, functional impairment, and health care utilization. …
Estudio parasitológico del pez luna, Mola mola (L.), en el Mediterráneo occidental
2012
En el presente trabajo se ha realizado, por primera vez, un estudio de la parasitofauna del pez luna, Mola mola (L.), del Mediterráneo español. Hasta la fecha, se trata del estudio más detallado y completo sobre los parásitos de este pez en todo el mundo. Se han analizado 106 peces durante el período 2005−2008: 104 procedentes de cuatro muestreos consecutivos en la almadraba de La Azohía (Cartagena, Murcia) y 2 varados en Canet de Berenguer y Almazora (Comunidad Valenciana). Además, también se ha tenido acceso a 61 peces luna, de la misma procedencia, mantenidos en el acuario L’Oceanogràfic de la Ciudad de las Artes y las Ciencias de Valencia durante el periodo 2004−2009, gracias al conveni…
Beauty and the brain: Investigating the neural and musical attributes of beauty during a naturalistic music listening experience
2020
ABSTRACTEvaluative beauty judgments are very common, but in spite of this commonality, are rarely studied in cognitive neuroscience. Here we investigated the neural and musical attributes of musical beauty using a naturalistic free-listening paradigm applied to behavioral and neuroimaging recordings and validated by experts’ judgments. In Study 1, 30 Western healthy adult participants rated continuously the perceived beauty of three musical pieces using a motion sensor. This allowed us to identify the passages in the three musical pieces that were inter-subjectively judged as beautiful or ugly. This informed the analysis for Study 2, where additional 36 participants were recorded with funct…
Mitochondrial dynamics in type 2 diabetes: Pathophysiological implications
2017
Mitochondria play a key role in maintaining cellular metabolic homeostasis. These organelles have a high plasticity and are involved in dynamic processes such as mitochondrial fusion and fission, mitophagy and mitochondrial biogenesis. Type 2 diabetes is characterised by mitochondrial dysfunction, high production of reactive oxygen species (ROS) and low levels of ATP. Mitochondrial fusion is modulated by different proteins, including mitofusin-1 (MFN1), mitofusin-2 (MFN2) and optic atrophy (OPA-1), while fission is controlled by mitochondrial fission 1 (FIS1), dynamin-related protein 1 (DRP1) and mitochondrial fission factor (MFF). PARKIN and (PTEN)-induced putative kinase 1 (PINK1) partici…
The thiol switch C684 in Mitofusin-2 mediates redox-induced alterations of mitochondrial shape and respiration
2017
Mitofusin-2 (MFN2) is a GTPase in the outer mitochondrial membrane involved in the regulation of mitochondrial fusion and bioenergetics. MFN2 also plays a role in mitochondrial fusion induced by changes in the intracellular redox state. Adding oxidized glutathione (GSSG), the core cellular stress indicator, to mitochondrial preparations stimulates mitochondrial fusion by inducing disulphide bond-mediated oligomer formation of MFN2 and its homolog MFN1 which involve cysteine 684 (C684) of MFN2. Mitochondrial hyperfusion represents an adaptive stress response that confers transient protection by increasing mitochondrial ATP production but how this depends on the thiol switch C684 in MFN2 has …
Identification of cryptic Candida species by MALDI-TOF mass spectrometry, not all MALDI-TOF systems are the same: focus on the C. parapsilosis specie…
2016
Data about the performance of MALDI-TOF mass spectrometry against cryptic Candida species are limited. According to our findings within the C. parapsilosis species complex, microbiologists should be aware that the choice of the instrument is critical for accurate species identification due to the risk of misidentification in the clinical setting.
Epidemiological cutoff values for fluconazole, itraconazole, posaconazole, and voriconazole for six Candida species as determined by the colorimetric…
2013
ABSTRACT In the absence of clinical breakpoints (CBP), epidemiological cutoff values (ECVs) are useful to separate wild-type (WT) isolates (without mechanisms of resistance) from non-WT isolates (those that can harbor some resistance mechanisms), which is the goal of susceptibility tests. Sensititre YeastOne (SYO) is a widely used method to determine susceptibility of Candida spp. to antifungal agents. The CLSI CBP have been established, but not for the SYO method. The ECVs for four azoles, obtained using MIC distributions determined by the SYO method, were calculated via five methods (three statistical methods and based on the MIC 50 and modal MIC). Respectively, the median ECVs (in mg/lit…
Candida albicans UBI3 and UBI4 promoter regions confer differential regulation of invertase production to Saccharomyces cerevisiae cells in response …
2002
Candida albicans ubiquitin genes UBI3 and UBI4 encode a ubiquitin-hybrid protein involved in ribosome biogenesis and polyubiquitin, respectively. In this work we show that UBI3 and UBI4 promoter regions confer differentialexpr ession consistent with the function of their encoded gene products. Hybrid genes were constructed containing the SUC2 coding region under the controlof UBI3 or UBI4 promoters in the yeast vector pLC7. Invertase production in Saccharomyces cerevisiae transformants was differentially regulated: the UBI4 promoter was induced by stress conditions (thermalupshift and/or starvation) whereas the UBI3 promoter conferred constitutive invertase production in growing yeast cells…