Search results for "ToP"

Mid- to Long-Term Outcomes of Cervical Disc Arthroplasty versus Anterior Cervical Discectomy and Fusion for Treatment of Symptomatic Cervical Disc Di…

2015

Purpose This study aimed to investigate the mid- to long-term outcomes of cervical disc arthroplasty (CDA) versus anterior cervical discectomy and fusion (ACDF) for the treatment of 1-level or 2-level symptomatic cervical disc disease. Methods Medline, Embase, and the Cochrane Central Register of Controlled Trials databases were searched to identify relevant randomized controlled trials that reported mid- to long-term outcomes (at least 48 months) of CDA versus ACDF. All data were analyzed by Review Manager 5.3 software. The relative risk (RR) and 95% confidence intervals (CIs) were calculated for dichotomous variables. The weighted mean difference (WMD) and 95%CIs were calculated for conti…

Pharmacokinetics of new oral anticoagulants: implications for use in routine care

2018

Introduction: Since 2008, new oral anticoagulants (NOACs) have been approved for the prevention of venous thromboembolism (VTE) in patients receiving hip or knee replacement surgery, prevention of stroke and systemic embolism in patients with non-valvular atrial fibrillation (NVAF), treatment of deep vein thrombosis (DVT), and pulmonary embolism (PE). Premarketing randomized clinical trials (RCTs) of NOACs demonstrated their non-inferiority in terms of efficacy vs. warfarin (traditional oral anticoagulant–TOA), with lower risk of serious adverse drug reactions, especially cerebral hemorrhages. In clinical practice, pharmacokinetic aspects of NOACs have to be carefully taken into account to …

What we learn about bipolar disorder from large-scale neuroimaging

2020

Abstract MRI‐derived brain measures offer a link between genes, the environment and behavior and have been widely studied in bipolar disorder (BD). However, many neuroimaging studies of BD have been underpowered, leading to varied results and uncertainty regarding effects. The Enhancing Neuro Imaging Genetics through Meta‐Analysis (ENIGMA) Bipolar Disorder Working Group was formed in 2012 to empower discoveries, generate consensus findings and inform future hypothesis‐driven studies of BD. Through this effort, over 150 researchers from 20 countries and 55 institutions pool data and resources to produce the largest neuroimaging studies of BD ever conducted. The ENIGMA Bipolar Disorder Workin…

I testi dell'analogia: introduzione alla prima edizione americana de L'architettura della città

2012

La tradizione dell’architetto-scrittore ha molti precedenti nella storia dell’architettura italiana. Dal Rinascimento all’Ottocento era caratteristica di certi architetti il presentare le loro idee in forma di trattati sistematici. Sul modello di Vitruvio, Alberti produsse il modello rinascimentale per tale tipo di scrittura. Fu seguito dalla trattatistica di Serlio e Palladio. Serlio compose una serie di volumi che costituirono veri e propri manuali per l’architettura, iniziando dall’edificio antico sino ad arrivare a riflessioni su lavori futuri non ancora realizzati. La rilevanza di tali progetti non costruiti, destinati a diventare più importanti dei modesti progetti effettivamente real…

Metafora e mitopoietica nella concezione musicale romantica

2009

Rotting Melancholy: The False Utopia of Kazuo Ishiguro's "The Buried Giant"

2018

Kazuo Ishiguro’s The Buried Giant (2015) constitutes an interesting contemporary reworking of the motif of melancholy. In the universe of the book – a combination of Arthurian setting with the elements of fantasy – people experience the peculiar state of melancholic oblivion brought upon them by the mysterious fog. Although this fog enables a peaceful coexistence of previous enemies, it also causes the feelings of overwhelming uneasiness and unidentified menace. In this context, Ishiguro’s vision appears to be the representation of the false utopia where memory is sacrificed to achieve ostensible perfection. This paper discusses the approaches to melancholy, both ancient and more contempora…

Stoalaisella asenteella?

2021

Toppdommerrollen i fotball : sammenhengen mellom angst og mental tøffhet og toppdommeres subjektive opplevelse av press i norsk fotball

2016

Masteroppgave i idrettsvitenskap - Universitetet i Agder 2016 Mental toughness, anxiety and pressure are well-used terms within sports, even though it can be difficult to understand the meaning of them. The purpose of this study was to examine the relationship between anxiety (cognitive- and somatic anxiety and self-confidence) and mental toughness, and top-class referees’ subjective experience on pressure as a soccer official. 183 top-class referees answered an online questionnaire. Mental toughness was measured by using the SMTQ and anxiety by using the CSAI-2. Of all the referees included in this study, 97.2% had been active footballers themselves, 44.3% had played on a high level. There…

CD40 activity on mesenchymal cells negatively regulates OX40L to maintain bone marrow immune homeostasis under stress conditions

2021

BackgroundWithin the bone marrow (BM), mature T cells are maintained under homeostatic conditions to facilitate proper hematopoietic development. This homeostasis depends upon a peculiar elevated frequency of regulatory T cells (Tregs) and immune regulatory activities from BM-mesenchymal stem cells (BM-MSCs). In response to BM transplantation (BMT), the conditioning regimen exposes the BM to a dramatic induction of inflammatory cytokines and causes an unbalanced T-effector (Teff) and Treg ratio. This imbalance negatively impacts hematopoiesis, particularly in regard to B-cell lymphopoiesis that requires an intact cross-talk between BM-MSCs and Tregs. The mechanisms underlying the ability of…

Mesenchymal Stem Cells Provide Better Results Than Hematopoietic Precursors for the Treatment of Myocardial Infarction

2010

Objectives The purpose of this study was to compare the ability of human CD34(+) hematopoietic stem cells and bone marrow mesenchymal stem cells (MSC) to treat myocardial infarction (MI) in a model of permanent left descendent coronary artery (LDA) ligation in nude rats. Background Transplantation of human CD34(+) cells and MSC has been proved to be effective in treating MI, but no comparative studies have been performed to elucidate which treatment prevents left ventricular (LV) remodelling more efficiently. Methods Human bone marrow MSC or freshly isolated CD34(+) cells from umbilical cord blood were injected intramyocardially in infarcted nude rats. Cardiac function was analyzed by echoc…