Search results for "Topic"
showing 10 items of 2844 documents
Facilitating Effect of Natural Frequencies: Size Does Not Matter
2009
The question of whether humans are able to work in a Bayesian way is currently a topic of substantial investigation. An important finding, reported by Gigerenzer and Hoffrage in 1995 is that Bayesian reasoning is facilitated when the information format corresponds to natural frequencies. The present concern was whether the facilitating effect of frequencies persists when natural frequencies relate to samples which are not convenient multiples of 10. 150 undergraduates participated as volunteers (42 men, 108 women; M age = 23 yr.). Analysis showed the effect of natural frequency formats was not dependent on size of reference class. Theoretical and practical implications are discussed.
Effects of structured patient education in adults with atopic dermatitis: Multicenter randomized controlled trial
2016
Background: Atopic dermatitis (AD) is a chronic relapsing skin disease prevalent in 1% to 3% of adults in Western industrialized countries. Objective: We sought to investigate the effectiveness of educational training in an outpatient setting on coping with the disease, quality of life, symptoms, and severity in adults with AD. Methods: In this German prospective, randomized controlled multicenter study, adult patients with moderate-to-severe AD were educated by referring to a comprehensive 12-hour training manual consented by a multiprofessional study group from different centers (Arbeitsgemeinschaft Neurodermitisschulung fur Erwachsene [ARNE]). Patients were randomly allocated to the inte…
Understanding symptoms in RYR1-Related Myopathies: A mixed-methods analysis based on participants' experience
2020
Background: In rare diseases such as ryanodine receptor 1-related myopathies (RYR1-RM), health-related quality of life (HRQoL) measures are critically important so clinicians and researchers can better understand what symptoms are most important to participants, with the ultimate goal of finding tangible solutions for them. Objectives: The main objective of this study was to characterize symptoms in individuals with RYR1-RM to inform future research. A secondary objective of this study was to analyze positive and negative sentiments regarding symptoms and treatment effects post N-acetylcysteine (NAC) administration in individuals with RYR1-RM. Methods: The study used a mixed-methods design …
Family members' lived experiences of everyday life after intensive care treatment of a loved one: a phenomenological hermeneutical study.
2015
Aims and Objectives To illuminate relatives’ experiences of everyday life after a loved one's stay in an intensive care unit. Background Relatives of intensive care patients experience considerable stress that can have a long-lasting effect on their everyday lives. Relatives frequently report anxiety, depression and complicated grief as a result of their experiences in the intensive care unit. Design A qualitative design was chosen. Methods Thirteen relatives were interviewed 3 months to 1 year after the discharge or death of an intensive care unit patient. A phenomenological hermeneutical method was used to explore family members’ lived experiences upon returning home after their loved one…
Outcomes after acute myocardial infarction in HIV-infected patients: analysis of data from a French nationwide hospital medical information database.
2013
Background— We aimed to assess in-hospital case fatality and 1-year prognosis in HIV-infected patients with acute myocardial infarction. Methods and Results— From the PMSI (Program de Medicalisation des Systèmes d’informatique) database, data from 277 303 consecutive acute myocardial infarction patients hospitalized from January 1, 2005, to December 31, 2009, were analyzed. Surviving patients were followed up for 1 year after discharge. HIV-infected patients were compared with uninfected patients. Among the cohort, HIV-infected patients (n=608) accounted for 0.22%. All-cause hospital and 1-year mortality rates were lower in the HIV-infected group than in uninfected patients (3.1% versus 8.…
Accuracy of check-bite registration and centric condylar position
2002
In a dentate subject a jaw relation can either be determined in maximum intercuspation and is as such given by the occlusal morphology, or the mandibular position can be allocated according to the centric position of the condyles. For comprehensive restorative treatment or analytic measures of the occlusion it is important to record the centric condylar position. Various registration methods have been described in the literature, but there is no consensus on which is the 'best'. The aim of the present study was therefore to assess the accuracy of various registration methods and evaluate a possible influence of the used materials. Four dentists were involved in the clinical part of the stud…
Investigation of the prevalence of impacted third molars and the effects of eruption level and angulation on caries development by panoramic radiogra…
2021
This study is aimed to determine the prevalence of impacted third molars and to investigate the effects of their eruption level and angulation on caries formation in the distal of the adjacent tooth. This cross-sectional study was conducted on panoramic radiographs of 38481 patients who were admitted to the Trakya University, Faculty of Dentistry. The panoramic radiographs of 7998 patients with at least one impacted third molar were included. Third molars were classified according to Winter?s classification and Pell and Gregory?s classification. The frequency of caries in partially impacted third molars and adjacent second molars was determined. The chi-square tests were used to determine p…
A German Validation Study of the Inventory to Diagnose Depression
1989
The Inventory to Diagnose Depression (IDD), a self-rating scale designed to identify major depressive episodes (MDE) according to DSM-III, was validated in a sample of 83 inpatients. Depending whether the time criterion of MDE was included or omitted, 63 or 77 patients obtained a syndrome diagnosis of MDE established by means of a structured clinical interview (Polydiagnostic Interview) which served as yardstick. Sensitivity (84.1% with time criterion, 89.6% without time criterion), specificity (60%, 50%), predictive value (67.8%, 64.2%) and kappa (0.43, 0.29) were calculated and found to necessitate improvement for a reasonable application of the IDD in epidemiological and clinical setting…
Relationship between rheological properties, in vitro release and in vivo equivalency of topical formulations of diclofenac.
2019
Determination of bioequivalence remains a challenge in generic topical drug development. To support pharmacokinetic studies, strategies to demonstrate microstructure sameness of the products being compared include in vitro evaluations, such as the comparison of rheological properties, droplet size and in vitro release rates. Nevertheless, defining the appropriate acceptance range to consider equivalence between test and reference formulation is complex. To shed more light into this issue, in vitro release and rheological properties were compared to in vivo bioequivalence data (systemic blood measurements within a clinical trial) after topical application of a single dose. Test and reference…
Immunoglobulin A response to acute stress in intimate partner violence perpetrators: the role of anger expression-out and testosterone.
2014
Aggressive behavior and immune activity are shown to be positively associated in perpetrators of intimate partner violence (IPV). This relationship follows an inverted-U curve, with the most violent individuals showing lower levels of immunocompetence than those with a history of moderate violence. Moreover, the activational and organizational effects of testosterone (T) may indirectly stimulate the immune response. Given this, we used the Trier Social Stress Test to establish whether the salivary immunoglobulin A (sIgA) response to acute stress was a specific psychobiological feature in perpetrators of intimate partner violence (IPV). IPV perpetrators showed higher sIgA levels than control…