Search results for "Topics"
showing 10 items of 90 documents
Comparison of HapMap and 1000 genomes reference panels in a large-scale genome-wide association study
2017
An increasing number of genome-wide association (GWA) studies are now using the higher resolution 1000 Genomes Project reference panel (1000G) for imputation, with the expectation that 1000G imputation will lead to the discovery of additional associated loci when compared to HapMap imputation. In order to assess the improvement of 1000G over HapMap imputation in identifying associated loci, we compared the results of GWA studies of circulating fibrinogen based on the two reference panels. Using both HapMap and 1000G imputation we performed a meta-analysis of 22 studies comprising the same 91,953 individuals. We identified six additional signals using 1000G imputation, while 29 loci were ass…
Characterization of neutrophil subsets in healthy human pregnancies
2014
We have previously shown that in successful pregnancies increased arginase activity is a mechanism that contributes to the suppression of the maternal immune system. We identified the main type of arginase-expressing cells as a population of activated low-density granulocytes (LDGs) in peripheral blood mononuclear cells and in term placentae. In the present study, we analyzed the phenotype of LDGs and compared it to the phenotype of normal density granulocytes (NDGs) in maternal peripheral blood, placental biopsies and cord blood. Our data reveal that only LDGs but no NDGs could be detected in placental biopsies. Phenotypically, NDGs and LDGs from both maternal and cord blood expressed diff…
The new neutron-rich isotope228Rn
1989
2 pages, 1 table, 2 figures.-- PACS nrs.: 23.90.+w; 27.90.+b.-- Section: Short Notes.
Advance booking across channels: The effects on dynamic pricing
2021
This research analyzes the effects of advance booking and channel type on hotel rates. While this relationship has been addressed in the literature, most studies take a partial approach by focusing only on one distribution channel or one destination. This study fills this gap by analyzing the price dynamics for four channels and multiple destinations. The data set consists of 39,363 bookings for 1085 hotels over 27 consecutive months. We used two-stage least squares to solve potential endogeneity issues, and the results proved that distribution channel, hotel type and hotel size have an influence on the effect of advance booking on hotel rates. Critical managerial implications are discussed…
Comment on “How skew distributions emerge in evolving systems” by Choi M. Y. et al.
2010
Power-law distributions and other skew distributions, observed in various models and real systems, are considered. As an example, critical exponents determined from highly accurate experimental data very close to the λ-transition point in liquid helium are discussed in some detail. A model, describing evolving systems with increasing number of elements, is considered to study the distribution over element sizes. Stationary power-law distributions are found. Certain non-stationary skew distributions are obtained and analyzed, based on exact solutions. Validerad; 2010; 20100908 (weber)
Ultrastrong Coupling of a Single Molecule to a Plasmonic Nanocavity: A First-Principles Study
2022
| openaire: EC/H2020/838996/EU//RealNanoPlasmon Funding Information: We acknowledge financial support from the Swedish Research Council (VR Miljö, Grant No: 2016-06059), the Knut and Alice Wallenberg Foundation (Grant No: 2019.0140), the Polish National Science Center (projects 2019/34/E/ST3/00359 and 2019/35/B/ST5/02477). T.P.R. acknowledges support from the European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie Grant Agreement No. 838996 and support from the Academy of Finland under the Grant No. 332429. T.J.A. acknowledges support from the Project HPC-EUROPA3 (INFRAIA-2016-1-730897), with the support of the EC Research Innovation Action under the H…
La vida cotidiana de los vecinos de Manila a través de sus testamentos e inventarios de bienes
2019
With the general objective indicated in its title, this work tries to highlight relevant aspects in the continuity of the Spanish domain in the Philippines, dependent on the maintenance of the Spanish capital. The inevitable selection of topics has lead the preferences of this work towards the residents collaboration to defend the city, the conversion of many of them into traders of exotic products and singular slaves owners, and their collaboration to an incredible miscegenation due to the ethnic variety. On the other hand, to follow the footsteps of the first generation of residents in Manila, at the end of the 16th century and during the 17th century, this work gives us some information …
Switching Dynamics of Dark Solitons in Kerr Microresonators
2019
Dissipative Kerr solitons (DKS) are localized structures in optical resonators that arise from a double balance between dispersion and Kerr effect, and linear loss and parametric gain [1]. The periodic nature of DKS corresponds to frequency combs. DKS can be generated in high-Q microresonators for diverse applications, from coherent communications to precision frequency synthesis [1]. Most studies of DKS have focused on microresonator cavities operating in the anomalous dispersion regime, where the waveforms correspond to bright soliton pulses. Coherent microresonator combs can also be formed in the normal dispersion regime [2]. The time-domain waveform corresponds to a localized dark-pulse…
Hot-cavity spectroscopy of dark pulse Kerr combs in microresonators
2019
Kerr frequency combs are generated through cascaded four-wave mixing in high-Q microresonators [1]. These devices are pumped with a continuous-wave laser and modulational instability (MI) is responsible for the growth of the initial comb lines. Since it is easier to satisfy the MI phase matching condition in the anomalous dispersion regime, most studies on Kerr combs have focused on anomalous dispersion microresonators. However, coherent microresonator combs can also take place in the normal dispersion regime. In these combs, phase matching is attained with the aid of the mode coupling between transverse modes of the microresonator [2]. One particularly interesting comb state that operates …
Application of thermodynamics to driven systems
2007
Application of thermodynamics to driven systems is discussed. As particular examples, simple traffic flow models are considered. On a microscopic level, traffic flow is described by Bando's optimal velocity model in terms of accelerating and decelerating forces. It allows to introduce kinetic, potential, as well as total energy, which is the internal energy of the car system in view of thermodynamics. The latter is not conserved, although it has certain value in any of two possible stationary states corresponding either to fixed point or to limit cycle in the space of headways and velocities. On a mesoscopic level of description, the size n of car cluster is considered as a stochastic varia…