Search results for "Toxic"
showing 10 items of 6968 documents
Always pay attention to which model of motor learning you are using
2022
This critical review considers the epistemological and historical background of the theoretical construct of motor learning for a more differentiated understanding. More than simply reflecting critically on the models that are used to solve problems—whether they are applied in therapy, physical education, or training practice—this review seeks to respond constructively to the recent discussion caused by the replication crisis in life sciences. To this end, an in-depth review of contemporary motor learning approaches is provided, with a pragmatism-oriented clarification of the researcher’s intentions on fundamentals (what?), subjects (for whom?), time intervals (when?), and purpose (for what…
Consequences of analgesics use in early pregnancy: Results of tests on mice.
2019
International audience; Self-medication during pregnancy continues to be an issue in developing countries due topoor medical education. The most commonly used drugs are analgesics, mainlyacetaminophen (paracetamol, APAP) and, to a lesser extent, ketoprofen (KPF). The aim of thestudy was to establish whether there are consequences of accidental use of these two drugsduring early embryogenesis. The experimental study was performed on 30 pregnant whitemice, divided into three groups: a first group to which APAP was administered, a secondgroup to which KPF was administered, and group 3 as a control group. At delivery, the babymice were examined, and after their first parturition, they were take…
Poly(I:C) and CpG-ODN combined aerosolization to treat lung metastases and counter the immunosuppressive microenvironment.
2015
The immunostimulatory ability of synthetic oligonucleotides containing CpG motifs (CpG-ODN), agonists of Toll-like receptor 9 (TLR9), can be harnessed to promote antitumor immunity by their application at the tumor site to stimulate local activation of innate immunity; however, particularly in the lung, tumor-associated immunosuppression can subvert such antitumor innate immune responses. To locally maintain continuous activation of innate subpopulations while inhibiting immunosuppressive cells, we evaluated aerosol delivery CpG-ODN combined with Poly(I:C), a TLR3 agonist able to convert tumor-supporting macrophages to tumoricidal effectors, in the treatment of B16 melanoma lung metastases …
An ultrasound-assisted digestion method for the determination of toxic element concentrations in ash samples by inductively coupled plasma optical em…
2007
method of ultrasound-assisted digestion followed by inductively coupled plasma optical emission spectrometry (ICP-OES) used for the determination of toxic element concentrations (arsenic, barium, cobalt, copper, lead, nickel, strontium, vanadium and zinc) in ash samples was developed. All the measurements were performed in robust plasma conditions which were tested by measuring the Mg(II) 280.270 nm/Mg(I) 285.213 nm line intensity ratios. The highest line intensity ratios were observed when a nebulizer gas flow of 0.6 L minˉ¹, auxiliary gas flow of 0.2 L minˉ¹ and plasma power of 1400 W were used for radially viewed plasma. The analysis of SRM 1633b showed that the ultrasound-assisted metho…
Toxicity of biomining effluents to Daphnia magna : Acute toxicity and transcriptomic biomarkers
2018
Increasing metal consumption is driving the introduction of new techniques such as biomining to exploit low grade ores. The biomining impacts notably aquatic ecosystems, yet, the applicability of ecotoxicological tests to study the complex mixture effects of mining waters is insufficiently understood. The aim of the present work was to test if transcriptomic biomarkers are suitable and sensitive for the ecotoxicity assessment of biomining affected waters. The study site had been affected by a multimetal biomine, and the studied water samples formed a concentration gradient of contamination downstream from the biomining site. Cadmium and nickel were used as positive controls in the toxicity …
In vitro toxicity assessment and mitigation strategies of beauvericin, sterigmatocystin and patulin / Evaluación de la toxicidad in vitro y estrategi…
2016
Las micotoxinas son contaminantes químicos naturales presentes en los alimentos y piensos que representan un problema preferente económico y de salud pública. El conocimiento de los efectos tóxicos y exposición a las micotoxinas permite caracterizar los riesgos de la población. Se ha evaluado la toxicidad de la beauvericina, esterigmatocistina y patulina de forma individual y combinada mostrando efectos citotóxicos. Se ha observado que todas las micotoxinas produjeron citotoxicidad de manera individual al aumentar la concentración y el tiempo de exposición, siendo las células CHO-K1 más sensibles de mayor a menor potencia a la patulina, beauvericina y esterigmatocistina. Además, se observar…
The Role of Fc Receptors on the Effectiveness of Therapeutic Monoclonal Antibodies.
2021
Since the approval of the first monoclonal antibody (mAb) in 1986, a huge effort has been made to guarantee safety and efficacy of therapeutic mAbs. As of July 2021, 118 mAbs are approved for the European market for a broad range of clinical indications. In order to ensure clinical efficacy and safety aspects, (pre-)clinical experimental approaches evaluate the respective modes of action (MoA). In addition to antigen-specificity including binding affinity and -avidity, MoA comprise Fc-mediated effector functions such as antibody dependent cellular cytotoxicity (ADCC) and the closely related antibody dependent cellular phagocytosis (ADCP). For this reason, a variety of cell-based assays have…
Molecular Identification and Biochemical Characterization of Novel Marine Yeast Strains with Potential Application in Industrial Biotechnology
2022
Cell-based agriculture is an emerging and attractive alternative to produce various food ingredients. In this study, five strains of marine yeast were isolated, molecularly identified and biochemically characterized. Molecular identification was realized by sequencing the DNA ITS1 and D1/D2 region, and sequences were registered in GenBank as Yarrowia lipolytica YlTun15, Rhodotorula mucilaginosa RmTun15, Candida tenuis CtTun15, Debaryomyces hansenii DhTun2015 and Trichosporon asahii TaTun15. Yeasts showed protein content varying from 26% (YlTun15) to 40% (CtTun15 and DhTun2015), and essential amino acids ranging from 38.1 to 64.4% of the total AAs (CtTun15-YlTun15, respectively). Lipid conte…
Sediment quality of the ecoregion Engure, Gulf of Riga, assessed by using ecotoxicity tests and biomarker responses
2014
Pētījuma mērķis bija novērtēt Engures ekoreģiona (Rīgas līča rietumu piekrastes) sedimentu kvalitāti, izmantojot sedimentu ekotoksicitātes testus. Lai noteiktu bioloģiskās atbildes reakcijas uz dažāda veida stresoriem, kā testorganismi pielietotas sānpeldes Monoporeia affinis and Pontogammarus robustoides, un izvēlēti biomarķieri (AChE, GST, GR, CAT, MT), kas noteikti gliemenēs Macoma balthica. Engures ekoreģionu varētu uzskatīt par nepiesārņotu rajonu, jo tā sedimentus raksturo salīdzinoši zemas smago metālu koncentrācijas. Engures ekoreģiona sedimentu ekotoksicitātes testu rezultāti neuzrādīja statistiski būtisku (>20% mirstība) toksisko efektu. Testorganismu izdzīvotība bija robežās no 8…
Comparison of Exposure Techniques and Vitality Assessment of Mosses in Active Biomonitoring for Their Suitability in Assessing Heavy Metal Pollution …
2021
The most widespread and used technique is the moss-bag method in active biomonitoring of air pollution using mosses. In the literature, we can find various studies on the standardization of this method, including attempts to standardize treatments and preparation procedures for their universal application. Few works comprehensively focus on other methods or compare other techniques used in active biomonitoring with mosses, especially including measurements of their vital parameters. Our experiment aimed to assess air pollution by selected heavy metals (Cu, Zn, Cd, Pb, Mn, Fe, and Hg) using three moss species (Pleurozium schreberi, Sphagnum fallax, and Dicranum polysetum) during a 12-week ex…