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RESEARCH PRODUCT

Consequences of analgesics use in early pregnancy: Results of tests on mice.

subject

description

International audience; Self-medication during pregnancy continues to be an issue in developing countries due topoor medical education. The most commonly used drugs are analgesics, mainlyacetaminophen (paracetamol, APAP) and, to a lesser extent, ketoprofen (KPF). The aim of thestudy was to establish whether there are consequences of accidental use of these two drugsduring early embryogenesis. The experimental study was performed on 30 pregnant whitemice, divided into three groups: a first group to which APAP was administered, a secondgroup to which KPF was administered, and group 3 as a control group. At delivery, the babymice were examined, and after their first parturition, they were taken into study and examinedaccording to the established protocol. Macroscopic and microscopic examinations of the liverand kidney were performed; liver and renal changes were recorded. Regarding the fertility,the number of fetuses born to mothers that were administered APAP and KPF correspondedto the normal values recorded in this species. Microscopic changes that were found in thekidney were as follows: APAP group  necrosis of the urinary tube, vascular congestions andvascular disorders; KPF group  ectasia, especially in the medullary cavity. Microscopichepatic changes showed in the APAP group  vascular congestions, vascular disorders andhemosiderin deposits in the Kupffer cells; in the KPF group were found  discrete vasculardisorders consisting in sinusoidal capillary ectasia and vascular congestions, as well as thepresence of lymphocyte conglomerates. The aforementioned lesions indicate hepatic and renaldistress with variable degrees of severity, but they appear to be reversible (the longer the timefrom the maximum effect of the drug the lower its toxicity).