Operational Procedures in the Theory of the Drug Release from Chitosan Hydrogels
We build a theoretical model based on a generalization of harmonic applications of Misner-type. It results a sine-Gordon type fractal differential equation whose elliptical solutions can describe, through a convenient choice of fractal dynamic constants, various modes of drug release. Thus, the entire class of empirical models (Higuchi, Korsmeyer-Peppas, Peppas-Sahlin) describing the drug release processes can be dispensed with.
Immuno-toxicological Evaluation of the Adjuvant Formulations for Experimental Anti-meningococcal Vaccines without Aluminium Hydroxide
International audience; The proteoliposomes and cochleates are used as adjuvants for vaccines since they are potent immune stimulators. However, the hyper stimulation of the immune system provoked by adjuvants can cause immunetoxicological side effects. The present study was carried out to evaluate the toxic and immuno-toxicological effects of new adjuvants for anti-meningococci vaccines based on neo-proteoliposomes (nPL) and neocochleates (nCh), in Balb/c mice that were administered doses of 15 µg each, over periods of 14 days through intramuscular route and three inoculations with the same doses through intranasal route, every 7 days. The Scanning and Transmission Electron Microscopy show…
Removal of Cypermethrin from Water by Using Fucus Spiralis Marine Alga
Alpha-cypermethrin is a synthetic pyrethroid that was extensively used for insect control, since the early 1980s. However, it is known that its presence in the environment has toxic effects on humans and aquatic life forms. For this reason, it is commendable for it to be removed completely from the contaminated environment. In this study, we evaluated the adsorption capacity of a marine alga for the removal of cypermethrin from water. The adsorption experiments were performed based on the batch equilibrium technique. The samples containing the pesticide were analyzed using gas chromatography with an electron capture detector, after liquid-liquid extraction in hexane. The results obtained fr…
Correlations between the Presence of Hurthle Cells and Cytomorphological Features of Fine-Needle Aspiration Biopsy in Thyroid Nodules
INTRODUCTION: The presence of Hürthle cells (HC) in fine needle thyroid biopsy (FNAB) is a real concern for a cytologist and also for an endocrinologist. We aimed to demonstrate if the presence of HC is associated with specific cytological features in FNAB results. MATERIAL AND METHODS: This retrospective study analyzed 89 patients diagnosed with thyroid nodules, with FNAB; were two groups of patients: the study group A (HC+) (22 patients) with HC and control group B (HC-) (67 patients) with no HC; for both groups we analyzed the presence of 9 cytomorphologic features: overall cellularity, background colloid, lymphocyte infiltration, chronic inflammation, large nucleoli, small nucleoli, syn…
The Seasonality Impact of the BTEX Pollution on the Atmosphere of Arad City, Romania
Benzene, toluene, and total BTEX (benzene, toluene, ethylbenzene, and xylene) concentrations registered for one year (2016) have been determined every month for one high-density traffic area. The assessment was performed in Arad City, Romania, to evaluate these pollutants and their influence on the inhabitants’ health. The contaminants were sampled using a static sampling method and analyzed by gas chromatography coupled with mass spectrometry. Benzene was the most dominant among the BTEX compounds—the average concentrations ranged from 18.00 ± 1.32 µg m−3 in December to 2.47 ± 0.74 µg m−3 in August. The average toluene concentration over the year was 4.36 ± 2.42 µg m−3 (with a maximum of 9…
The Effects of Oregano Oil on Fungal Infections Associated with Metabolic Syndrome
International audience; This study aims to compare the evolution of mycosis associated with metabolic syndrome under allopathic treatment compared to phytotherapy using oregano essential oil. The study was conducted over a period of 6 months, on a total of 72 patients diagnosed with fungal infections associated with metabolic syndrome. The patients were divided into 3 groups, depending on the administered treatment: group 1: 24 patients who received allopathic treatment; group 2: 24 patients who received oregano oil treatment; group 3: control, which did not undergo any antifungal treatment. All three groups were subjected to specific diet therapy for mycosis. The patients were initially ev…
Assessment of Physical and Chemical Stability of Different Magnesium Compounds in Tablets
Modern lifestyle, excessive chemicalization of agricultural products, excessive processing and refining of food, cause a decrease in daily intake of magnesium, cation with an extremely important role in prevention and treatment of many diseases. As a result, there arises the need for extra magnesium intake in the form of dietary supplements. In this study were evaluated the physical and chemical stability of magnesium-containing tablets, depending on the active compound and the excipients used. Magnesium tablets in the form of orotate, lactate, citrate, oxide and hydroxide were taken into study and physical and chemical stability were observed over the validity period, at 6 and at 12 month…
The Effects of Pandemic Restrictions on Public Health-Improvements in Urban Air Quality.
The present study aims to provide evidence on the effects of pandemic curtailment measures on public health, targeting the changes in breathable air quality, within urban areas. The analyzed period covers the full impact of lockdowns in Europe in 2020. We used everyday data for each analyzed pollutant, NO2, SO2, CO, PM2.5 and PM10, from urban monitoring stations that provided real-time concentrations (provided by Copernicus Atmosphere Monitoring Service, Environmental Protection Agency repository and European Environment Agency map services) and satellite data (provided by NASA Orbiting Carbon Observatory 2). In the present study, the urban air quality was computed using a composite index t…
Anisotropy Influences on the Drug Delivery Mechanisms by Means of Joint Invariant Functions
In the frame of Higuchi’s type functionality, this paper presents the anisotropy influences on the drug delivery mechanisms through the joint invariant functions to the simultaneous actions of the two SL(2R) isomorphic groups. Then, a new equation for drug delivery mechanism, independent of the type of polymer matrix and/or drug, is proposed.
Estimation of the Amount of Disposed Antibiotics
The impact of the antibiotics in the environment is not well understood yet. Moreover, the total amount of antibiotics that are ending up in the environment as solid waste is not known and cannot be rigorously determined as many variables are influencing the determination of their concentration. The present article is focused on the estimation of the amount of non-prescribed antibiotics that are used in different European countries. Particular attention is paid to the class of beta-lactams, as they are responsible for a considerate share of the antimicrobial resistance. The primary purpose was the estimation of the quantity of non-prescribed antibiotics that might reach the environment as s…
Consequences of analgesics use in early pregnancy: Results of tests on mice.
International audience; Self-medication during pregnancy continues to be an issue in developing countries due topoor medical education. The most commonly used drugs are analgesics, mainlyacetaminophen (paracetamol, APAP) and, to a lesser extent, ketoprofen (KPF). The aim of thestudy was to establish whether there are consequences of accidental use of these two drugsduring early embryogenesis. The experimental study was performed on 30 pregnant whitemice, divided into three groups: a first group to which APAP was administered, a secondgroup to which KPF was administered, and group 3 as a control group. At delivery, the babymice were examined, and after their first parturition, they were take…
Physical, Psychological and Sexual Abuse of the Minor in the Families from the Northwestern Region of Romania- Social and Medical Forensics
Background: In Romania, the abuse within the family of the minor child is a widespread phenomenon, its extent is insufficiently known because of ignorance/not reporting all the existing cases.
 Methods: The participants of the research are represented by two independent groups from the NW Romania 2007-2011, one for sociological study (1544 parents and 1283 children) and another for forensic statistical study (2761 cases of abused children). The sociological study was carried out by analyzing questionnaires applied in schools located in Bihor County, both to children and parents. The statistical analysis was carried out by studying the cases of the physically, sexually, and psychologica…
The Safety of Slaughterhouse Workers during the Pandemic Crisis
The working conditions in a slaughterhouse are difficult because of the low temperatures, high humidity, and little natural light. Therefore, in these facilities, there is a high demand in the maintenance of strict hygiene rules. Lately, the new SARS-CoV-2 pandemic situation has brought new challenges in the meat industry, as this sector has to maintain its operability to supply the meat and meat products demanded by the consumers. In this challenging period, the safety of the workers is as important as keeping the high demands for the safety of the meat and meat products along with consumer confidence. This paper aims to give an overview of the risks associated with the SARS-CoV-2 virus tr…
Variations in the Chemical Composition of the Essential Oil of Lavandula angustifolia Mill., Moldoveanca 4 Romanian Variety
International audience; In this research, the variations in the chemical composition of the Lavandula angustifolia Mill. essential oil, the Romanian variety Moldoveanca 4, obtained from the same culture, in the same harvesting and extraction conditions, during the years 2016-2018, representing the years 2-4 of culture. Lavandula angustifolia Mill. flowers were supplied from an ecological-crops from N-E Romania and the essential oils were obtained by hydro distillation of freshly harvested flowers. To determine the chemical composition, the essential oil was semi-quantitatively analysed by using gas chromatography coupled with mass spectrometry (GC-MS). In all the samples, 30 organic compoun…