Search results for "Toxic"
showing 10 items of 6968 documents
Trait Variation between Two Wild Specimens of Pleurotus ostreatus and Their Progeny in the Context of Usefulness in Nematode Control
2022
Pleurotus ostreatus is one of the most widespread mushrooms in the world. It is a valuable and widely cultivated edible mushroom with nematicidal properties. The mycelium of this mushroom produces a toxin that paralyzes nematodes, after which the nematode becomes infected with the filament, resulting in its death. This feature can be put to practical use as a natural nematicidal agent. In this paper, we have described studies on two wild strains of P. ostreatus (PO1, PO2) and the monokaryotic progeny obtained from their fruiting bodies. Monokaryons were crossed with each other within the progeny of one strain (PO1xPO1; PO2xPO2) and of two different strains (PO2xPO1). The growth conditions, …
Intrauterine and Neonatal Exposure to Opioids: Toxicological, Clinical, and Medico-Legal Issues
2023
Opioids have a rapid transplacental passage (i.e., less than 60 min); furthermore, symptoms characterize the maternal and fetal withdrawal syndrome. Opioid withdrawal significantly impacts the fetus, inducing worse outcomes and a risk of mortality. Moreover, neonatal abstinence syndrome (NAS) follows the delivery, lasts up to 10 weeks, and requires intensive management. Therefore, the prevention and adequate management of NAS are relevant public health issues. This review aims to summarize the most updated evidence in the literature regarding toxicological, clinical, and forensic issues of intrauterine exposure to opioids to provide a multidisciplinary, evidence-based approach for managing …
Acción del sugamadex y de los bloqueantes neromusculares: rocuronio y vecuronio en neuronas en cultivo primario
2017
INTRODUCCIÓN: El ROCURONIO y VECURONIO son los relajantes musculares no despolarizantes BNMNP más usados en la práctica clínica. El SUGAMADEX es el fármaco utilizado como reversor de la relajación muscular producida por los bloqueantes neuromusculares citados. En el presente trabajo analizamos los efectos del SUGAMADEX, la implicación del colesterol en los mismos y el posible papel protector del ROCURONIO y VECURONIO en cultivos primarios de neuronas de rata. HIPÓTESIS: Debido a la introducción paulatina del fármaco SUGAMADEX en la clínica y de los bloqueantes neuromusculares tipo ROCURONIO y VECURONIO, nos planteamos si estos fármacos o su combinación podrían ocasionar muerte neuronal en c…
Neural Classification of Compost Maturity by Means of the Self-Organising Feature Map Artificial Neural Network and Learning Vector Quantization Algo…
2019
Self-Organising Feature Map (SOFM) neural models and the Learning Vector Quantization (LVQ) algorithm were used to produce a classifier identifying the quality classes of compost, according to the degree of its maturation within a period of time recorded in digital images. Digital images of compost at different stages of maturation were taken in a laboratory. They were used to generate an SOFM neural topological map with centres of concentration of the classified cases. The radial neurons on the map were adequately labelled to represent five suggested quality classes describing the degree of maturation of the composted organic matter. This enabled the creation of a neural separator classify…
Antitumor Cell-Complex Vaccines Employing Genetically Modified Tumor Cells and Fibroblasts
2014
The present study evaluates the immune response mediated by vaccination with cell complexes composed of irradiated B16 tumor cells and mouse fibroblasts genetically modified to produce GM-CSF. The animals were vaccinated with free B16 cells or cell complexes. We employed two gene plasmid constructions: one high producer (pMok) and a low producer (p2F). Tumor transplant was performed by injection of B16 tumor cells. Plasma levels of total IgG and its subtypes were measured by ELISA. Tumor volumes were measured and survival curves were obtained. The study resulted in a cell complex vaccine able to stimulate the immune system to produce specific anti-tumor membrane proteins (TMP) IgG. In the g…
Estudio sobre atención médica urgente en los establecimientos balnearios.
1999
1.- Introducción Los balnearios fueron considerados como hoteles termales para uso estival de pacientes adinerados. El único tratamiento médico era la ingesta de determinadas aguas, capaces de producir efectos terapeúticos (sobre todo a nivel digestivo y renal). Pero el turismo de playa de los años 70 hizo que los clientes cambiaran de hábitos, entrando la mayoría de los balnearios en la decrepitud y la ruina. La puesta en marcha del Programa de Termalismo Social colaboró a la restauración, tanto de las instalaciones como de los hábitos termales en la población geriátrica.2.- Objetivos Analizar el número y las distintas características de las urgencias que se produjeron en el Balneario Herv…
Structural Manipulations of Marine Natural Products Inspire a New Library of 3-Amino-1,2,4-Triazine PDK Inhibitors Endowed with Antitumor Activity in…
2023
Pancreatic ductal adenocarcinoma (PDAC) is one of the main aggressive types of cancer, characterized by late prognosis and drug resistance. Among the main factors sustaining PDAC progression, the alteration of cell metabolism has emerged to have a key role in PDAC cell proliferation, invasion, and resistance to standard chemotherapeutic agents. Taking into account all these factors and the urgency in evaluating novel options to treat PDAC, in the present work we reported the synthesis of a new series of indolyl-7-azaindolyl triazine compounds inspired by marine bis-indolyl alkaloids. We first assessed the ability of the new triazine compounds to inhibit the enzymatic activity of pyruvate de…
Conectividad dinámica y vulnerabilidad de los ecosistemas acuáticos en entornos agrícolas costeros: La Albufera de Valencia como caso de estudio
2023
Los humedales costeros, considerados indispensables por los numerosos servicios ecosistémicos que proporcionan a la humanidad, se encuentran en la actualidad altamente amenazados por las continuas presiones antrópicas, y en especial, por la actividad agrícola. Entre los principales impactos derivados de la agricultura destacan la extracción de las reservas de agua dulce, la alteración de los regímenes hidrológicos naturales, y la degradación de la calidad química y estado trófico de los ecosistemas acuáticos naturales que constituyen estos complejos y dinámicos parajes naturales. El principal problema a la hora de desarrollar y aplicar estrategias de monitorización, conservación y restaurac…
Antineoplastic dosing in overweight and obese cancer patients: an Associazione Italiana Oncologia Medica (AIOM)/Associazione Medici Diabetologi (AMD)…
2021
Most anticancer molecules are administered in body-size-based dosing schedules, bringing up unsolved issues regarding pharmacokinetic data in heavy patients. The worldwide spread of obesity has not been matched by improved methods and strategies for tailored drug dosage in this population. The weight or body surface area (BSA)-based approaches may fail to fully reflect the complexity of the anthropometric features besides obesity in cancer patients suffering from sarcopenia. Likewise, there is a lack of pharmacokinetic data on obese patients for the majority of chemotherapeutic agents as well as for new target drugs and immunotherapy. Therefore, although the available findings point to the …
Effects of Job Content and Physical Activity on Body Mass Index among Obese Managers of the Mexican Manufacturing Industry
2020
Mental health disorders resulting from work stressors are increasing in the Mexican manufacturing industry and worldwide. Managerial positions in these contexts are highly stressful, and although physical activity may reduce the negative effects of work stress, the relationships between these two aspects regarding their effects on the body mass index (BMI) of obese managers are scarcely studied. This article aims to study such relationships by using the Job Content Questionnaire (JCQ) dimensions with the Baecke’s physical activity questionnaire dimensions and analyzing their effects on the BMI. A sample of 255 managers from the Mexican industry, with a (BMI > 30) participated by answerin…