Search results for "Trail"

Goldenin häiriökriteeri TM-B -testissä epilepsioiden kognitiivisessa diagnostiikassa

1999

A Branch-and-Cut Algorithm for the Single Truck and Trailer Routing Problem with Satellite Depots

2016

International audience; In the single truck and trailer routing problem with satellite depots (STTRPSD), a truck with a detachable trailer based at a main depot must serve the demand of a set of customers accessible only by truck. Therefore, before serving the customers, it is necessary to detach the trailer in an appropriate parking place (called either a satellite depot or a trailer point) and transfer goods between the truck and the trailer. This problem has applications in milk collection for farms that cannot be reached using large vehicles. In this work we present an integer programming formulation of the STTRPSD. This formulation is tightened with several families of valid inequaliti…

Branch-and-Price-and-Cut for the Truck-and-Trailer Routing Problem with Time Windows

2018

In this paper, we present a new branch-and-price-and-cut algorithm to solve the truck-and-trailer routing problem with time windows (TTRPTW) and two real-world extensions. In all TTRPTW variants, the fleet consists of one or more trucks that may attach a trailer. Some customers are not accessible with a truck-and-trailer combination, but can however be serviced by one if the trailer is previously detached and parked at a suitable location. In the first extension, the planning horizon comprises two days and customers may be visited either on both days or only once, in which case twice the daily supply must be collected. The second extension incorporates load transfer times depending on the …

A new design approach to the use of composite materials for heavy transport vehicles

2007

In order to keep or to reach a high level of competitiveness and performance of a product, it is necessary to explore all the possible solutions that allow the best compromise between costs and project requirements. By this point of view the study of alternative designs and/or materials to use, is an important aspect that can identify a new concept or way of thinking about a product. This paper presents how to make use of composite materials in the field of heavy vehicles transportation. A new semitrailer in composite material has been designed, using a methodical redesign approach and an optimisation process. The main innovation in this project is, besides the use of the Glass Fibre Reinfo…

Death receptors as targets in cancer

2014

Anti-tumour therapies based on the use PARAs (pro-apoptotic receptor agonists), including TRAIL (TNF-Related Apoptosis inducing Ligand) or monoclonal antibodies targeting TRAIL-R1 or TRAIL-R2, have been disappointing so far, despite clear evidence of clinical activity and lack of adverse events for the vast majority of these compounds, whether combined or not with conventional or targeted anti-cancer therapies. This brief review aims at discussing the possible reasons for the lack of apparent success of these therapeutic approaches and at providing hints in order to rationally design optimal protocols based on our current understanding of TRAIL signalling regulation or resistance for future…

Il·lustració radical i contrail·lustració en Hamann i Herder: La polèmica sobre l'origen del llenguatge

2015

És ben coneguda la hipòtesi sobre l’origen del llenguatge que Johann Gottfried Herder va defensar en l’Abhandlung über den Ursprung der Sprache, premiat per l’Acadèmia de Berlín en 1771. Hi ofereix la visió d’un ésser humà capaç de desenvolupar de forma autònoma la predisposició al llenguatge que Déu li havia inserit. L’home desplega l’habilitat lingüística, d’una banda, des de la situació de dispersió que pateix el seu sentit interior pel fet de distanciar-se respecte de la determinació dels instints, més pròpia dels animals; i, d’altra banda, gràcies a la capacitat de concentrar l’atenció d’aquest sentit interior en un punt, un signe lingüístic que li serveix a la consciència per a flexio…

The Trailer as Erotic Capital. Gendered Performances—Research and Participant Roles during Festival Fieldwork

2019

This article examines different roles and field relations of the researcher in studies of young people at Christian festivals. The main questions are how the researcher gains access to the &ldquo

Magmatic gas percolation through the old lava dome of El Misti volcano

2017

International audience; The proximity of the major city of Arequipa to El Misti has focused attention on the hazards posed by the active volcano. Since its last major eruption in the fifteenth century, El Misti has experienced a series of modest phreatic eruptions and fluctuating fumarolic activity. Here, we present the first measurements of the compositions of gas emitted from the lava dome in the summit crater. The gas composition is found to be fairly dry with a H2O/SO2 molar ratio of 32 ± 3, a CO2/SO2 molar ratio of 2.7 ± 0.2, a H2S/SO2 molar ratio of 0.23 ± 0.02 and a H2/SO2 molar ratio of 0.012 ± 0.002. This magmatic gas signature with minimal evidence of hydrothermal or wall rock int…

INVOLVEMENT OF ER-STRESS IN SPARC UP-REGULATION INDUCED BY WIN AND IN APOPTOSIS OF MG63 CELLS

2012

L'hyperthermie provoque l'agrégation de FLIP et restaure l'apoptose induite par TRAIL

2014

The TNF-family member TRAIL (TNF-related apoptosis inducing ligand) is a cytokine involved in the immune anti-tumour surveillance. TRAIL is a promising agent currently under investigation for its anti-cancer properties with limited side effects on healthy cells. However, the use of TRAIL in oncology has been limited due to its lack of efficiency, mainly associated with cell resistance to apoptosis. The aim of this project was to study the interest of hyperthermia (or heat shock - HS) as an adjuvant for TRAIL therapy and the mechanisms involved in this sensitization.We have first evaluated the significance of this combination in a large variety of cancer cell lines known to be sensitive or r…