Search results for "Trail"

STUDIO DEI MECCANISMI DI MORTE CELLULARI INDOTTI DAL CANNABINOIDE SINTETICO WIN IN CELLULE TUMORALI IN COLTURA

2014

Per lungo tempo, i cannabinoidi sono stati considerati come farmaci lenitivi ma non curativi della patologia cancerosa. Tuttavia, negli scorsi anni, è stata suggerita una potenziale applicazione dei cannabinoidi come droghe antitumorali, anche se il loro meccanismo d’azione non è ancora ben conosciuto. Gli obiettivi di questo studio sono stati: - la valutazione degli effetti del cannabinoide sintetico WIN55,212-2 (WIN) su differenti linee di cellule tumorali in coltura (cellule di carcinoma colorettale HT29 e cellule di osteosarcoma umano MG63) e – la valutazione dei meccanismi molecolari indotti dal trattamento con il cannabinoide. I risultati riportati indicano che in entrambe le linee ce…

The mechanism by which histone deacetylase inhibitors sensitize hepatoma and colon cancer cells to TRAIL-induced apoptosis

2008

IL TRATTAMENTO COMBINATO SAHA/TRAIL INDUCE IN CELLULE DI CARCINOMA MAMMARIO MDA-MB231 IL DISTACCO E LA MORTE PER ANOIKIS

2011

The synthetic cannabinoid WIN sensitizes hepatocellular carcinoma cells to TRAIL-induced apoptosis by activating p8/CHOP/DR5 axis.

2010

In this paper we demonstrate that the synthetic cannabinoid WIN sensitizes human hepatocellular carcinoma (HCC) cells to apoptosis mediated by TNF-related apoptosis inducing ligand (TRAIL). The apoptotic mechanism induced by treatment with WIN/TRAIL combination involved the loss of the mitochondrial transmembrane potential and led to the activation of caspases. In HCC cells WIN treatment induced up-regulation of TRAIL death receptor DR5, an effect which seemed to be related to the increase in the level of p8 and CHOP, two factors implicated in cellular stress response and apoptosis. This relationship was suggested by the observation that the down-regulation of p8 or CHOP by specific siRNAs …

Social media, percorsi e narrazioni: una geografia digitale del turismo naturalistico

2023

Il turismo, soprattutto quello di massa, può avere un impatto negativo sull’ambiente e sulle culture locali. Al fine di superare questa criticità negli ultimi anni si sono moltiplicate le proposte di forme di turismo alternativo. Tra queste il turismo naturalistico offre delle interessanti opportunità, oggi accentuate dalla diffusione dei social media e da piattaforme digitali realizzate per aiutare e incentivare gli utenti propensi ad esplorare gli ambienti naturali. In questo lavoro, oltre a descrivere le più comuni dinamiche e criticità riguardanti il turismo naturalistico, si approfondisce il caso della piattaforma digitale AllTrails. Social media, routes and narrations: a digital geogr…

Research of prognostic biomarkers in Tunisian patients with bladder cancer

2016

Bladder cancer is the first most common urogenital cancer in men in Tunisia, with a high recurrence rate. Patients with muscle-invasive disease develop metastasis. The need for expensive continuous surveillance. In this thesis we try to search some candidate biomarkers. Their use for cancer staging and personalization of therapy at the time of diagnosis in order to identify a better treatment could improve patient care. The aim of this first part of our study was to investigate the clinical significance of three immune cell-related transcription factors, T-bet, GATA-3 and Bcl-6 in Tunisian patients with bladder cancer. We found that T-bet level was significantly higher in invasive carcinoma…

The transcription factor CHOP is critical for WIN-mediated DR5 up-regulation in apoptosis induced by WIN/TRAIL co-treatment in hepatoma cells

2009

An unconventional TRAIL to cancer therapy

2013

Editorial: Activation, functions, and generation of immunological memory in γδ T lymphocytes: lessons from nonhuman primates

2014

T cells constitute an unconventional lymphocyte population with distinct functions complementary to those of CD4 and CD8 T cells. As such, they have both adaptive features, such as expression of the TCR, and innate-like functions reminiscent of NK cells, with whom they share extensive repertoires of activating and inhibitory receptors [1, 2]. Although most antigens recognized by murine T cells remain obscure, advances have been made in identifying ligands for human T cells. The majority of circulating human T lymphocytes expresses a TCR formed by the preferentially-paired V 9 and V 2 chains (here and thereafter, called V 9V 2 T cells). Instead of binding peptides associated with molecules b…

Impact of wheeled and tracked tractors on soil physical properties in a mixed conifer stand

2016

Abstract: Damage to forest soil caused by vehicle traffic mainly consists of soil compaction, displacement, and rut formation. Severity of the damage depends on vehicle mass, weight of the carried loads, ground morphology, and soil properties, such as moisture. This paper investigates the impacts of two types of vehicles (tracked or wheeled tractor), traffic intensities (one or five skidding cycles) and soil moisture (24% or 13% by weight) on compaction of a loam textured soil in a mixed conifer stand of central Italy. Changes in porosity, bulk density, shear and penetration resistances were analyzed. The latter three parameters were significantly higher in the trafficked soil portions than…