Search results for "Transform"
showing 10 items of 3975 documents
Tree Based Domain-Specific Mapping Languages
2012
Model transformation languages have been mainly used by researchers --- the software engineering industry has not yet widely accepted the model driven software development (MDSD). One of the main reasons is the complexity of metamodelling principles the developers are required to know to actually use model transformations in the way the OMG has stated. We offer the basic principles how to create domain-specific model transformation languages which can be used by developers relying only on familiar modelling concepts. We propose to use simple graphical mappings to specify the correspondence between source and target models which are represented using trees based on the concrete syntax of und…
Model Transformation Languages and Their Implementation by Bootstrapping Method
2008
In this paper a sequence of model transformation languages L0, L1, L2 is defined. The first language L0 is very simple, and for this language it is easy to build an efficient compiler to C++. The next language L1 is an extension of L0, and it contains powerful pattern definition facilities. The last language L2 is of sufficiently high level and can be used for implementation of traditional pattern-based high level model transformation languages, as well as for the development of model transformations directly. For languages L1 and L2 efficient compilers have been built using the bootstrapping method: L1 to L0 in L0, and L2 to L1 in L1. The results confirm the efficiency of model transformat…
Settlement strategies of the Dominicans in Palermo from the Middle Ages to the late Baroque
2014
This paper proposes some reflections on the settlement strategies pursued by the Dominicans in Palermo between the founding of the first conventual settlements, from the 13th century to the transformations of the 17th and 18th centuries as a result of expansion and renovation projects imposed by the Counter-Reformation. The research analyzes for the first time the dialogue between the architecture promoted by the Dominicans and the becoming of the city over the centuries through the continuous and articulated design traces and construction relating to different locations pertaining to enforcement, male (San Domenico and Santa Cita) and female (Santa Caterina and Santa Maria della Pietà), pl…
Diagnosis of Incipient Bearing Faults using Convolutional Neural Networks
2019
The majority of faults occurring in rotating electrical machinery is attributed to bearings. To reduce downtime, it is desired to apply various diagnostic methods so that bearing degradation can be detected in good time prior to a complete failure. The work presented in this paper utilizes a data-driven machine learning approach based on convolutional neural networks (CNNs) in order to diagnose different types of bearing faults. A one-dimensional CNN is trained on vibration signals and compared to a two-dimensional CNN trained in time-frequency domain using continuous wavelet transform (CWT). The proposed method is demonstrated on data collected from run-to-failure tests.The results show th…
Can NF-κB Be Considered a Valid Drug Target in Neoplastic Diseases? Our Point of View
2020
Multidrug resistance (MDR), of the innate and acquired types, is one of major problems in treating tumor diseases with a good chance of success. In this review, we examine the key role of nuclear factor-kappa B (NF-κB) to induce MDR in three tumor models characterized precisely by innate or acquired MDR, in particular triple negative breast cancer (TNBC), hepatocellular carcinoma (HCC), and acute myeloid leukemia (AML). We also present different pharmacological approaches that our group have employed to reduce the expression/activation of this transcriptional factor and thus to restore chemo-sensitivity. Finally, we examine the latest scientific evidence found by other groups, the most sign…
Saliva testing after single and chronic administration of dihydrocodeine.
2001
In the present study, concentrations of dihydrocodeine and its metabolites in saliva and serum were compared after single low-dose and chronic high-dosage administration of the drug. In the first investigation, blood and saliva were collected periodically from six subjects after oral administration of 60 mg dihydrocodeine. In the second study, 20 subjects on oral dihydrocodeine maintenance provided single samples of blood and saliva simultaneously. Serum protein binding of salivary analytes and their recovery from the adsorbing material of the collection device as well as pH values of saliva samples were determined. The fluids were analyzed for dihydrocodeine and the major metabolites by hi…
Biochemical approach on the conservation of drug molecules during hair fiber formation
1997
A biochemical concept for the endogenous incorporation of drug molecules into growing hair is presented. It is based on the principles of transport across biomembranes, on the principles of biotransformation and drug melanin affinity. The approach gives explanations for current observations in hair analysis, which up to date have not been understood sufficiently. Phenomena such as the ratio of parent drug to metabolite in hair, the dependence of incorporation on the physico-chemical properties of the drug, the independence of drug incorporation on active melanogenesis (incorporation into non-pigmented hair) as well as the dependence of drug content on hair pigmentation are elucidated.
Hepatocytes--the choice to investigate drug metabolism and toxicity in man: in vitro variability as a reflection of in vivo.
2007
The pharmaceutical industry is committed to marketing safer drugs with fewer side effects, predictable pharmacokinetic properties and quantifiable drug-drug interactions. Drug metabolism is a major determinant of drug clearance and interindividual pharmacokinetic differences, and an indirect determinant of the clinical efficacy and toxicity of drugs. Progressive advances in the knowledge of metabolic routes and enzymes responsible for drug biotransformation have contributed to understanding the great metabolic variations existing in human beings. Phenotypic as well genotypic differences in the expression of the enzymes involved in drug metabolism are the main causes of this variability. How…
Drug biotransformation by human hepatocytes. In vitro/in vivo metabolism by cells from the same donor.
2001
Abstract Background/Aims : Cultured human hepatocytes are considered a close model to human liver. However, the fact that hepatocytes are placed in a microenvironment that differs from that of the cell in the liver raises the question: to what extent does drug metabolism in vitro reflect that of the liver in vivo? This issue was examined by investigating the in vitro and in vivo metabolism of aceclofenac, an analgesic/anti-inflammatory drug. Methods : Hepatocytes isolated from programmed liver biopsies were incubated with aceclofenac, and the metabolites formed were investigated by HPLC. During the course of clinical recovery, patients were given the drug, and the metabolites, largely prese…
A Colorimetric Membrane-Based Sensor with Improved Selectivity towards Amphetamine
2021
Due to their simplicity, speed and low cost, chemical spot tests are increasingly demanded for the presumptive identification of illicit drugs in a variety of contexts such as point-of-care assistance or prosecution of drug trafficking. However, most of the colorimetric reactions used in these tests are, at best, drug class selective. Therefore, the development of tests based on chemical reactions with improved discrimination power is of great interest. In this work, we propose a new colorimetric assay for amphetamine (AMP) based on its reaction with solutions of alkaline gold bromide to form an insoluble yellow–orange derivative. The resulting suspensions are then filtered onto nylon membr…