Search results for "Transform"
showing 10 items of 3975 documents
Ledrappier-Young formula and exact dimensionality of self-affine measures
2017
In this paper, we solve the long standing open problem on exact dimensionality of self-affine measures on the plane. We show that every self-affine measure on the plane is exact dimensional regardless of the choice of the defining iterated function system. In higher dimensions, under certain assumptions, we prove that self-affine and quasi self-affine measures are exact dimensional. In both cases, the measures satisfy the Ledrappier-Young formula. peerReviewed
Local cubic splines on non-uniform grids and real-time computation of wavelet transform
2017
In this paper, local cubic quasi-interpolating splines on non-uniform grids are described. The splines are designed by fast computational algorithms that utilize the relation between splines and cubic interpolation polynomials. These splines provide an efficient tool for real-time signal processing. As an input, the splines use either clean or noised arbitrarily-spaced samples. Formulas for the spline’s extrapolation beyond the sampling interval are established. Sharp estimations of the approximation errors are presented. The capability to adapt the grid to the structure of an object and to have minimal requirements to the operating memory are of great advantages for offline processing of s…
Apoptotic-like Leishmania exploit the host´s autophagy machinery to reduce T-cell-mediated parasite elimination
2015
Apoptosis is a well-defined cellular process in which a cell dies, characterized by cell shrinkage and DNA fragmentation. In parasites like Leishmania, the process of apoptosis-like cell death has been described. Moreover upon infection, the apoptotic-like population is essential for disease development, in part by silencing host phagocytes. Nevertheless, the exact mechanism of how apoptosis in unicellular organisms may support infectivity remains unclear. Therefore we investigated the fate of apoptotic-like Leishmania parasites in human host macrophages. Our data showed--in contrast to viable parasites--that apoptotic-like parasites enter an LC3(+), autophagy-like compartment. The compartm…
Mutant HRAS as novel target for MEK and mTOR inhibitors.
2015
HRAS is a frequently mutated oncogene in cancer. However, mutant HRAS as drug target has not been investigated so far. Here, we show that mutant HRAS hyperactivates the RAS and the mTOR pathway in various cancer cell lines including lung, bladder and esophageal cancer. HRAS mutation sensitized toward growth inhibition by the MEK inhibitors AZD6244, MEK162 and PD0325901. Further, we found that MEK inhibitors induce apoptosis in mutant HRAS cell lines but not in cell lines lacking RAS mutations. In addition, knockdown of HRAS by siRNA blocked cell growth in mutant HRAS cell lines. Inhibition of the PI3K pathway alone or in combination with MEK inhibitors did not alter signaling nor had an imp…
Artificial cartilage bio-matrix formed of hyaluronic acid and Mg2+-polyphosphate.
2016
Here we show that inorganic polyphosphate (polyP), a polyanionic metabolic regulator consisting of multiple phosphate residues linked by energy-rich phosphoanhydride bonds, is present in the synovial fluid. In a biomimetic approach, to enhance cartilage synthesis and regeneration, we prepared amorphous polyP microparticles with Mg2+ as counterions. The particles were characterised by X-ray diffraction (XRD), energy-dispersive X-ray (EDX) and Fourier transformed infrared spectroscopic (FTIR) analyses. Similar particles were obtained after addition of Mg2+ ions to a solution containing hyaluronic acid, as a major component of the synovial fluid, and soluble Na-polyP. The viscous paste-like ma…
Alterations of panoramic radiomorphometric indices in children and adolescents with beta-thalassemia major: A fractal analysis study
2021
Background Beta-thalassemia major is an inherited disorder that can cause bone deformity and loss of bone mineral density. The objective of this study is to evaluate the cortical and trabecular mandibular bone morphology of children and adolescents who have beta-thalassemia major (ß-TM) using a fractal dimension (FD) analysis and different panoramic radiomorphometric indices with digital panoramic radiographic images (DPRIs). Material and Methods The study included 80 patients (with 40 patients each of ß-TM and control). The mandibular cortical width (MCW), panoramic mandibular index (PMI), mandibular cortical index (MCI), and simple visual estimation (SVE) were evaluated, and an FD analysi…
Opinion dynamics, stubbornness and mean-field games
2014
This paper studies opinion dynamics and stubbornness using mean-field game theory. Assuming an initial exponential density function and affine control policies we analyze under what conditions the Fokker-Planck equation returns an exponential density function over the horizon. Consensus and clusters formation are also studied.
Ri _ GENERAZIONI. Reversibili
2016
Vogliamo ora la maestria del “meccanico” in luogo di quella del “muratore”. Vogliamo architetti capaci di costruire mentre pensano a dover o poter smontare. Troppo spesso assistiamo alla supponenza di tanti manufatti che si arrogano il diritto di sentirsi immortali e invece sono solo premature obsolescenze non più governabili. I tempi di realizzazione dell’architettura contemporanea sono giurassici; spesso l’edificio non è ancora completato è già sono mutate le circostanze per cui lo si è voluto mentre stiamo riconoscendo di non potere più tornare indietro. L’architettura oggi non riesce più a stare al passo con le continue mutazioni che l’ambiente e la società impongono (ormai sempre più r…
The Complex Identities of Latvians Abroad: What Shapes a Migrant’s Sense of Belonging?
2019
AbstractBuilding on the data from The Emigrant Communities of Latvia survey, this chapter aims to reveal and describe the complex nature of the sense of geographic and social belonging of those who became emigrants. It will explore the factors affecting the maintenance of their identity and consider transformation processes among migrants. The starting point of this chapter is the assumption that the ‘sense of belonging’ is affected by a variety of different objective and subjective factors, and that identity is multi-faceted. Instead of facing a trade-off between feeling close to the home country or host country, or developing a supranational identity, different combinations of types of a …
Antecedent variables of innovation behaviors in organizations: Differences between men and women
2016
Abstract Introduction Relevance of innovation behaviors for organizational success led to study its main individual, job-related and organizational antecedents. Moreover, research on differences in innovation between men and women showed inconclusive results. Ambidexterity (Bledow, Frese, Anderson, Erez, & Farr, 2009) and Zhou and Hoever (2014) call for combining contextual and personal characteristics in innovation research suggest that pathways and variables leading to innovation between men and women could be different. Objective(s) This study aims to analyze if men and women differ in the main antecedents for innovative behaviors. Thus, a moderating effect of gender on the relationship …