Search results for "Transmitter"
showing 10 items of 348 documents
Pharmacological blockade of the fatty acid amide hydrolase (FAAH) alters neural proliferation, apoptosis and gliosis in the rat hippocampus, hypothal…
2015
Endocannabinoids participate in the control of neurogenesis, neural cell death and gliosis. The pharmacological effect of the fatty acid amide hydrolase (FAAH) inhibitor URB597, which limits the endocannabinoid degradation, was investigated in the present study. Cell proliferation (phospho-H3(+) or BrdU(+) cells) of the main adult neurogenic zones as well as apoptosis (cleaved caspase-3(+)), astroglia (GFAP(+)), and microglia (Iba1(+) cells) were analyzed in the hippocampus, hypothalamus and striatum of rats intraperitoneally treated with URB597 (0.3 mg/kg/day) at one dose/4-days resting or 5 doses (1 dose/day). Repeated URB597 treatment increased the plasma levels of the N-acylethanolamine…
Evidence that adenosine is not involved in the non-adrenergic non-cholinergic relaxation in the rat duodenum.
1990
In rat isolated duodenal segments, adenosine induced, in the presence of atropine and guanethidine, a dose-dependent, long-lasting (about 20 s), tetrodotoxin (TTX)-resistant relaxation both in endoluminal pressure and in isometric tension. Electrical field stimulation (EFS) induced, in the presence of atropine and guanethidine, a TTX-sensitive short-lasting (about 6 s) relaxation followed by a sustained rebound contraction. Theophylline, a P1 receptor antagonist, at the concentration of 100 microM caused a marked inhibition of the adenosine-induced relaxation, while the EFS-induced relaxation was not modified. Our results suggest that adenosine induces relaxation of the rat duodenal smooth …
PACAP induces bradycardia in guinea-pig heart by stimulation of atrial cholinergic neurones
1996
Based on previous studies which indicated that pituitary adenylate cyclase activating peptide (PACAP) acts as a positive inotropic and chronotropic substance in different species via the cAMP signal transduction pathway, the objective of the present work was to investigate cAMP-regulated myocardial key proteins in response to PACAP in isolated ventricular cells of the guinea pig. Surprisingly, the two molecular forms of PACAP, PACAP(1-27) and PACAP(1-38), showed no effect on intracellular cAMP-levels, L-type Ca2+ channel current or phosphorylation of troponin inhibitor (TnI) and phospholamban (PLB). Additionally, inotropy of isolated guinea-pig ventricular strips was not affected by the neu…
Muscarinic Modulation of Acetylcholine Release from the Myenteric Plexus of the Guinea Pig Small Intestine
1978
The concept of a local feedback regulation of neurotransmitter release has been most intensively studied in the adrenergic system (See Ref. 13 for review). The feedback hypothesis of noradrenaline release is based on the findings that α-adrenolytic drugs enhance, and α-adrenoceptor agonists reduce neuronal noradrenaline release. Relatively few systematic studies have been made on the influence of cholinolytic and cholinomimetic drugs on the release of ACh. Szerb and Somogyi (14) reported that the potent muscarinic agonist oxotremorine inhibited ACh output from cerebral cortical slices. Further, the muscarinic antagonists atropine and hyoscine have been found to facilitate the release of ACh…
Doppler Estimation and Correction for JANUS Underwater Communications
2020
In recent years, underwater communications have seen a growing interest pushed by marine research, oceanography, marine commercial operations, offshore oil industry and defense applications. Generally, underwater communications employ audio signals which can propagate relatively far but are also significantly affected by Doppler distortions. In fact, physical properties of the water and spatial changes due to tides, currents and waves can cause channel variations or unwanted movements of the transmitter or receiver. This study shows how to compensate for the Doppler effect in transmission employing the JANUS standard, a popular modulation scheme for underwater communication. Differently for…
Wireless battery chargers for portable applications: Design and test of a high-efficiency power receiver
2013
In this study, the authors present a 5 W wireless battery charger for handheld devices. Efficiency-related issues are addressed. A power receiver architecture which improves power conversion efficiency is proposed. Design hints are provided for further applications. Comparison with a conventional architecture is provided as well. Laboratory prototypes of both the proposed and the conventional architectures have been realised. Both prototypes are tested by using the same power transmitter to perform a valuable comparison. As shown by the experimental results, in the receiver side power conversion efficiency is increased up to 99% thanks to the proposed solution.
Wireless battery charging: E-bike application
2013
Nowadays, Inductive Power Transfer (IPT) represents a widely investigated issue with respect to modern battery charging methods, by providing a wireless solution. IPT is applied across a large variety of applications, from Watt to kWatt power levels. Although IPT features great benefits in terms of safety and comfort, the most significant drawback consists of a relatively poor power conversion efficiency. In this paper, a 100W wireless charging equipment for E-bikes which improves efficiency is proposed. Complete magnetic structure design, as well as transmitter and receiver efficient architectures, are deeply exposed. The efficiency of the designed solution is shown by simulation results.
E-bike battery charging: Methods and circuits
2013
Today, academic and industrial research is focused on innovative battery charging methods to ensure complete mobility of both handheld devices and electric vehicles. Wireless power transfer is actually the leading strategy even if efficiency related issues are to be solved for a successful marketing. In this paper, a wireless battery charging station is proposed for electric assisted pedal bikes. If compared with existing wireless solutions, the proposed system architecture improves power conversion efficiency of the charging equipment. The simulation model of the whole charging station is described in detail. The transmitter, receiver and inductive coupling circuits are described and desig…
Control subsystem design for wireless power transfer
2014
Recently, the wireless power transfer has been increasingly employed. Particularly for the electric vehicles, the wireless solution is attractive for contactless battery charging, based on the Inductive Power Transfer (IPT). In this paper, a 150W prototype for IPT-based battery charging is presented and design criteria are reported. In addition to the power stage analysis, a proper control strategy is proposed. Simulation and experimental results are shown. The proposed control method aims at regulating the load current against variations in the magnetic coupling, so that the required amount of power can be supplied despite of unexpected decreases in the coupling efficiency.
Elusive amines and cluster headache: mutational analysis of trace amine receptor cluster on chromosome 6q23.
2004
Cluster headache (CH) is characterised by unilateral pain and ipsilateral autonomic features. To date, no molecular genetic evidence has been shown for CH. Small pedigrees and low penetrance render the identification of the CH-gene quite difficult. Nonetheless the association of CH and migraine to a new class of amine, namely trace or elusive amines such as tyramine, octopamine and synephrine, has recently been demonstrated. In particular, in comparison to healthy control subjects, all these neurotransmitters have been found to be greatly elevated in CH sufferers in plasma and platelets both in active and remission periods. A cluster of gene-encoding G-protein-coupled receptors that bind an…