Search results for "Trial"
showing 10 items of 10525 documents
Is Sertraline a Good Pharmacological Strategy to Control Anger? Results of a Systematic Review
2019
Introduction: Extensive research has made it possible to conclude that dysfunctions in serotoninergic transmission are associated with a tendency toward violence and behavioral dysregulations in humans. In this regard, it has been suggested that selective serotonin reuptake inhibitors (SSRIs), such as sertraline, which regulate the serotonin system, might reduce proneness to violence. Aims: This review aims to explore changes in feelings of anger-state (e.g., irritability and hostility) and anger expression as primary outcomes after sertraline treatment. Methods: Based on PRISMA quality criteria for reviews, a literature search was carried out through PubMed, PsycINFO, Dialnet, Psicodoc, We…
Depression is Associated with Moderate-Intensity Physical Activity Among College Students During the COVID-19 Pandemic: Differs by Activity Level, Ge…
2020
Jingyuan Lin,1,* Tianyou Guo,2,* Benjamin Becker,3 Qian Yu,2 Si-Tong Chen,4 Stubbs Brendon,5 Md Mahbub Hossain,6 Paolo M Cunha,7 Fernanda Cunha Soares,8 Nicola Veronese,9 Jane Jie Yu,10 Igor Grabovac,11 Lee Smith,12 Albert Yeung,13 Liye Zou,2 Hong Li1 1Research Centre of Brain Function and Psychological Science; Center for Language and Brain, Shenzhen Institute of Neuroscience; Shenzhen Key Laboratory of Affective and Social Cognitive Science, School of Psychology, Shenzhen University, Shenzhen, 518060, People’s Republic of China; 2Exercise and Mental Health Laboratory, School of Psychology, Shenzhen University, Shenzhen 518060, People’s Republic of China; 3The Clinical …
Are Treatment Gains Maintained? Long-term Psychological Interventions for Bordeline Personality Disorder
2017
IntroductionMany new approaches have been developed to treat borderline personality disorder (BPD) by means of psychotherapy. Though there is a clear research trend towards short-interventions, the evidence from randomised controlled trials (RCT) on longer-term programmes still accumulates. On the one hand, well-established treatments like Dialectical Behavior Therapy (DBT) or Mentalisation-Based Treatment (MBT) are now subject to real-world effectiveness studies; on the other hand, new dynamic approaches have been studied, lasting longer than 6 months.ObjectivesWe are currently updating the cochrane Collaboration review on psychological interventions for BPD. First findings on the effects …
Exercise therapy for chronic musculoskeletal pain: Innovation by altering pain memories.
2015
Even though nociceptive pathology has often long subsided, the brain of patients with chronic musculoskeletal pain has typically acquired a protective (movement-related) pain memory. Exercise therapy for patients with chronic musculoskeletal pain is often hampered by such pain memories. Here the authors explain how musculoskeletal therapists can alter pain memories in patients with chronic musculoskeletal pain, by integrating pain neuroscience education with exercise interventions. The latter includes applying graded exposure in vivo principles during exercise therapy, for targeting the brain circuitries orchestrated by the amygdala (the memory of fear centre in the brain). Before initiatin…
Medication-related osteonecrosis of the jaws (MRONJ) in cancer patients treated with denosumab VS. zoledronic acid : a systematic review and meta-ana…
2020
Background The aim of the present study was to analyse the incidence, risk ratio (RR) and prognoses of two types of medication-related osteonecrosis of the jaws (MRONJ): denosumab-related osteonecrosis of the jaws (DRONJ) and Bisphosphonate-Related Osteonecrosis of the Jaws (BRONJ) in cancer patients under treatment with denosumab or zoledronic acid (ZA). Material and Methods An electronic and manual search was conducted for randomized controlled trials (RCTs) until May 2019. Assessment of the identified studies, risk of bias and data extraction were performed independently by two reviewers. The incidence of DRONJ and BRONJ and the RR to develop MRONJ were calculated at 1 year, 2 years and …
Poincaré surface profile. Novel non-invasive method to detect preferential ventricular response during atrial fibrillation
2007
The strategy of rate control during atrial fibrillation (AF) essentially deals with efforts to utilize and adjust the filtering properties of the atrioventricular (AV) node, allowing AF to continue and ensure that ventricular rate is controlled. In this work, a new tool based on the 3D Poincare plots is developed for the characterization of the ventricular response (VR) and the clinical evaluation of rate control therapies. Mechanisms underlying atrioventricular conduction during AF remain unclear. The role of the dual pathway AV nodal electrophysiology and the effects of the AV node modifications are still being an incognita. RR interval clusters exhibiting harmonic behaviour have been qua…
Magnification in apical surgerymusing the endoscope: a review
2011
Objective: A review is made to determine whether the use of the endoscope in endodontic surgery offers advantages in clinical practice, and whether it improves the clinical and radiographic outcomes of the procedure. Material and methods: The main search terms used were: endodontic surgery, apicoectomy, apical surgery, endoscope, and magnification devices . The authors searched the Medline database for articles published up to 1 September 2010. The review included experimental studies comparing endoscopic microstructural findings with the findings of the naked eye or other magnification devices, as well as prospective clinical trials comparing endodontic surgery with or without the use of a…
Quantitative assessment of regularity and synchronization of intracardiac recordings during human atrial fibrillation
2003
This study proposes the morphology-based evaluation of the regularity (R) and the synchronization (S) of intra-atrial electrograms acquired during atrial fibrillation (AF). R is defined as the degree of repetitiveness over time of the shapes of the activation waves detected in single atrial recordings. S accounts for the simultaneous presence of morphologically similar activation waves in two atrial electrograms, and for the dispersion of the propagation delays between the two sites. Both R and S resulted unitary for normal sinus rhythm and decreased significantly moving from atrial flutter (R=0.93, S=0.88) to AF of increasing complexity class (type I AF: R=0.75, S=0.66; type II AF: R=0.32,…
Randomized clinical trial comparing liver resection with and without perioperative assessment of liver function
2018
Background Liver function tests may help to predict outcomes after liver surgery. The aim of this study was to evaluate the clinical impact on postoperative outcome and patient management of perioperative liver function testing using the LiMAx® test. Methods A multicentre RCT was conducted in six academic liver centres. Patients with intrahepatic tumours scheduled for open liver resection of at least one segment were eligible. Patients were randomized to undergo additional perioperative liver function tests (LiMAx® group) or standard care (control group). Patients in the intervention arm received two perioperative LiMAx® tests, one before the operation for surgical planning and another afte…
Mechanical recanalization in basilar artery occlusion: The ENDOSTROKE study
2015
Objective A study was undertaken to evaluate clinical and procedural factors associated with outcome and recanalization in endovascular stroke treatment (EVT) of basilar artery (BA) occlusion. Methods ENDOSTROKE is an investigator-initiated multicenter registry for patients undergoing EVT. This analysis includes 148 consecutive patients with BA occlusion, with 59% having received intravenous thrombolysis prior to EVT. Recanalization (defined as Thrombolysis in Cerebral Infarction [TICI] score 2b–3) and collateral status (using the American Society of Interventional and Therapeutic Neuroradiology/Society of Interventional Radiology collateral grading system) were assessed by a blinded core l…