Search results for "Trial"
showing 10 items of 10525 documents
Systematic review and meta-analysis of the efficacy and safety of minocycline in schizophrenia
2017
ObjectiveOur aim was to perform an updated systematic review and meta-analysis on the efficacy and safety of adjunctive minocycline as a treatment of schizophrenia.MethodsWe conducted a PubMed/Scopus database search from inception to 3 February 2016 for randomized, placebo-controlled trials (RCTs), open non-randomized studies, and case reports/series evaluating minocycline in patients with schizophrenia. Random-effects meta-analysis of positive, negative, depressive, and cognitive symptom rating scales, discontinuation and adverse effects rates calculating standardized mean difference (SMD), and risk ratios±95% confidence intervals (CI95%) were calculated.ResultsSix RCTs were eligible (mino…
Safety and Tolerance Evaluation of Milk Fat Globule Membrane-Enriched Infant Formulas: A Randomized Controlled Multicenter Non-Inferiority Trial in H…
2014
ObjectiveThis multicenter non-inferiority study evaluated the safety of infant formulas enriched with bovine milk fat globule membrane (MFGM) fractions.MethodsHealthy, full-term infants ( n = 119) age ≤14 days were randomized to standard infant formula (control), standard formula enriched with a lipid-rich MFGM fraction (MFGM-L), or standard formula enriched with a protein-rich MFGM fraction (MFGM-P). Primary outcome was mean weight gain per day from enrollment to age 4 months (non-inferiority margin: –3.0 g/day). Secondary (length, head circumference, tolerability, morbidity, adverse events) and exploratory (phospholipids, metabolic markers, immune markers) outcomes were also evaluated.Res…
Improving the Downwind Sail Design Process by Means of a Novel FSI Approach
2021
The process of designing a sail can be a challenging task because of the difficulties in predicting the real aerodynamic performance. This is especially true in the case of downwind sails, where the evaluation of the real shapes and aerodynamic forces can be very complex because of turbulent and detached flows and the high-deformable behavior of structures. Of course, numerical methods are very useful and reliable tools to investigate sail performances, and their use, also as a result of the exponential growth of computational resources at a very low cost, is spreading more and more, even in not highly competitive fields. This paper presents a new methodology to support sail designers in ev…
A methodological look at the controversy about the influence of salt intake on cardiovascular risk
2012
Cardiovascular diseases are a major cause of premature death and disability. They represent an extraordinarily strong financial burden upon health-care systems in ‘‘developed’’ countries. Elevated blood pressure is a major cause of cardiovascular disease. There is much evidence that cardiovascular risk increases from normal blood pressure (i.e., from 115/75 mmHg upwards) [1]. Overwhelming evidence shows that reducing salt intake from 9–12 g/day to 5–6 g/day lowers blood pressure [2]. Blood pressure is a surrogate endpoint, but may be related to a reduction of morbidity and mortality due to cardiovascular causes. Thus, intensive support and encouragement to cut down on the intake of salt in …
Evaluación del estrés laboral y sus consecuencias en trabajadores del sector sanitario. Una perspectiva de género
2017
Título: Evaluación del estrés laboral y sus consecuencias en trabajadores del sector sanitario. Una perspectiva de género Nombre: Llorca Rubio, José Luis Universidad: Universitat de València (Estudi General) Programa de doctorado: Ciencias Sociales, del Trabajo y de los RR.HH. Dirección: Pedro Rafael Gil Monte Resumen: Introducción: Los riesgos psicosociales son unos factores de riesgo importante en el ámbito laboral en el momento actual (Arechavala, y Trapero, 2010, INSHT, 2011) debido sobre todo a las importantes consecuencias sobre la salud de los trabajadores y sobre las organizaciones (Agencia Europea para la Seguridad y Salud en el Trabajo, 2002; Molinera, 2006) lo que supone unos ele…
Why Use Interactive Multi-Objective Optimization in Chemical Process Design?
2008
Problems in chemical engineering, like most real-world optimization problems, typically, have several conflicting performance criteria or objectives and they often are computationally demanding, which sets special requirements on the optimization methods used. In this chapter, we point out some shortcomings of some widely used basic methods of multi-objective optimization. As an alternative, we suggest using interactive approaches where the role of a decision maker or a designer is emphasized. Interactive multi-objective optimization has been shown to suit well for chemical process design problems because it takes the preferences of the decision maker into account in an iterative manner tha…
Legacy Effects of Contrasting Long-Term Integrated Weed Management Systems
2022
To reduce reliance on herbicides and maintain crop productivity, integrated weed management (IWM) seeks to optimize synergies between diverse sets of weed management practices combined at the cropping system scale. Nevertheless, data on weed community response to the long-term implementation of IWM practices remain scare. Here, we assessed the effects of four IWM systems with contrasting objectives and practices (S2: transition from superficial tillage to conservation agriculture; S3: no-mechanical weeding; S4: mixed mechanical and chemical weeding; S5: herbicide-free; all with 6 year rotations) compared to a conventional reference (S1: herbicide-based with systematic plowing and a 3 year r…
Review article: recommended reading list of early publications on atomic layer deposition - outcome of the "virtual Project on the History of ALD"
2017
Atomic layer deposition (ALD), a gas-phase thin film deposition technique based on repeated, self-terminating gas-solid reactions, has become the method of choice in semiconductor manufacturing and many other technological areas for depositing thin conformal inorganic material layers for various applications. ALD has been discovered and developed independently, at least twice, under different names: atomic layer epitaxy (ALE) and molecular layering. ALE, dating back to 1974 in Finland, has been commonly known as the origin of ALD, while work done since the 1960s in the Soviet Union under the name "molecular layering" (and sometimes other names) has remained much less known. The virtual proj…
Capire la città post-industriale: riflessioni multi-disciplinari e multi-territoriali
2010
Resoconto delle due giornate di lavori del seminario internazionale "Understanding the post-Industrial City: Metropolis, Urban Renewal and Public Space" tenutosi a Lisbona nei giorni 3 e 4 di dicembre 2009.