Search results for "Triazolopyridines"
showing 6 items of 6 documents
Synthesis and in vitro leishmanicidal activity of novel [1,2,3]triazolo[1,5-a]pyridine salts
2017
Leishmaniasis remains a significant worldwide problem; it is of great interest to develop new drugs to fight this disease. Recently we described some [1,2,3] triazolo[1,5-a] pyridine compounds with significant leishmanicidal activity. The importance of water solubility in drug action made us realise that we could transform non charged triazolopyridines into charged analogues that could increase the degree of water solubility. With this objective we report here the synthesis of novel [1,2,3] triazolo[1,5-a] pyridinium salts 2-7 from triazolopyridines 1, and the study of their in vitro leishmanicidal activity. The activity was tested on Leishmania infantum, Leishmania braziliensis and Leishma…
Evaluation and synthesis of 7-arylhydroxymethyltriazolopyridines as potential cardiovascular agents
2002
7-Arylhydroxymethyltriazolopyridines 3a-c and 4a-d were synthesized by regioselective lithiation of [1,2,3]triazolo[1,5-a]pyridines 1 and 2 and subsequent trapping of the 7-lithioderivatives formed using aryl aldehydes as electrophiles. The structural relationship between compounds 3a-c and 4a-d and arylethanolamines suggested their consideration as potential cardiovascular agents. A preliminary evaluation as vascular smooth muscle relaxants was carried out. These compounds did not act as α1-adrenoceptor antagonists and were unable to block calcium entry through voltage-dependent calcium channels. Abarca Gonzalez, Belen, Belen.Abarca@uv.es ; Ballesteros Campos, Rafael, Rafael.Ballesteros@uv…
Synthesis of novel polypyridylcarbonylpyridines from triazolopyridines. Building blocks in supramolecular chemistry
2009
The synthesis from triazolopyridines 1, of novel triazolopyridylcarbonylpyridylcarbonyltriazolopyridines (TPyCOPyCOTPy) (tpcpctp) 7, and polypyridylcarbonylpyridines (pPyCOPy) (ppcp) 14, building blocks in supramolecular chemistry, is described. These compounds are interesting polynitrogenated ligands as potential molecular sensors, new magnetic materials, single molecular magnets, or in the emerging science of nanomaterials. Abarca Gonzalez, Belen, Belen.Abarca@uv.es ; Ballesteros Campos, Rafael, Rafael.Ballesteros@uv.es ; Chadlaoui, Mimoun, michad@alumni.uv.es
Pyridylcarbene formation by thermal decomposition of 7-bromo-3-methyl-[1,2,3]triazolo[1,5-a]pyridine under pressure
2007
7-Bromo-3-methyl-[1,2,3]triazolo[1,5-a]pyridine 1 at 1.7 atm and 100ºC decompose to form a pyridylcarbene intermediate by nitrogen expulsion. The carbene stabilization give 2-bromo-6- vinylpyridine 2, 1-(6-bromopyridin-2-yl)ethanol 3, 1-(6-Bromopyridin-2-yl)ethanone 4, 2- bromo-6-[2-(6-bromopyridin-2-yl)-2-methyl-trans-cyclopropyl]pyridine 5, and 2-bromo-6-[2-(6- bromopyridin-2-yl)-2-methyl-cis-cyclopropyl]pyridine 6. Abarca Gonzalez, Belen, Belen.Abarca@uv.es ; Ballesteros Campos, Rafael, Rafael.Ballesteros@uv.es
Triazolopyridines. Part 27.1 the preparation of novel 6,7-dihydro[1,2,3] triazolo[1,5-a]pyridines
2010
A very efficient synthesis of the unknown family of 6,7-dihydro[1,2,3]triazolo[1,5-a]pyridines from [1,2,3]triazolo[1,5-a]pyridines have been developed, and a mechanism for their formation has been proposed. Their behaviour with NBS to give 4,5-dibromo substituted-4,5,6,7-tetrahydro-[1,2,3]triazolo[1,5-a]pyridines is studied. Abarca Gonzalez, Belen, Belen.Abarca@uv.es ; Adam Ortiz, Rosa, Rosa.Adam@uv.es ; Ballesteros Campos, Rafael, Rafael.Ballesteros@uv.es
Triazolopyridines 21.1 The stereochemistry of 1-[1,2,3]triazolo [1,5-a] pyridin-7-yl-4-(2h-[1,2,3]triazol-4-yl)-1,3-butadienes and triazolo ring open…
2002
The synthesis and NMR study of the geometry of 1-[1,2,3]triazolo[1,5-a]pyridin-7-yl-4-(2H- [1,2,3]triazol-4-yl)-1,3-butadienes 1a, 1b, 5 and of new 1-(6-substituted-2-pyridyl)-4-(2H- [1,2,3]triazol-4-yl)-1,3-butadienes 8-10 is reported. The stereochemistry of all butadienes studied is 1E, 3E except for compound 5 that is the 1Z, 3Z stereoisomer of 1a. Abarca Gonzalez, Belen, Belen.Abarca@uv.es ; Ballesteros Campos, Rafael, Rafael.Ballesteros@uv.es