Search results for "Type"
showing 10 items of 10618 documents
Effectiveness of Gamification in Knee Replacement Rehabilitation : Protocol for a Randomized Controlled Trial With a Qualitative Approach
2022
Background: Exergames can provide encouraging exercise options. Currently, there is limited evidence regarding home-based exergaming in the postoperative phase of total knee replacement (TKR). Objective: This study aimed to investigate the effects of a 4-month postoperative home-based exergame intervention with an 8-month follow-up on physical function and symptoms among older persons undergoing TKR compared with home exercise using a standard protocol. In addition, a concurrent embedded design of a mixed methods study was used by including a qualitative component within a quantitative study of exergame effects. Methods: This was a dual-center, nonblinded, two-arm, parallel group randomized…
Pohjoismaiset hyötypelit
2008
Uutispelien suunnittelu
2015
Pelien suunnittelu on pelinkehityksen osa-alue, jota voidaan lähestyä tieteellisistä näkökulmista, ja näistä on julkaistu useita kirjoja ja tieteellisiä artikkeleja. Uutispelien suunnittelua ei kuitenkaan ole näissä julkaisuissa käsitelty melkeinpä ollenkaan. Tässä pro gradu -tutkielmassa tutkitaan uutispelien suunnittelua. Tutkimuksen aineistona on Jyväskylän yliopistossa keväällä 2015 järjestetyn Uutispeliprojekti-kurssin suorittaneiden opiskelijoiden täyttämät tutkimuskyselyt ja kurssilla valmiiksi saadut uutispelit. Vastauksia vertailtiin pelitutkimuksen eri pelisuunnittelun ohjeistuksien avulla. Tutkimuksen tavoitteena oli selvittää, miten Uutispeliprojekti-kurssilla suunnitellaan uuti…
Agenttien uskottavuus ja tekotyperyys digitaalisissa peleissä
2012
Tutkielmassa tarkastellaan pelin hahmojen eli agenttien uskottavuutta. Uskottava agentti käyttäytyy pelaajan odotusten mukaisesti. Tekstissä pohditaan, mitkä seikat vaikuttavat agentin uskottavuuteen, ja miten uskottavuus vaikuttaa pelin viihdyttävyyteen. Työssä pyritään tuomaan esille, kuinka agentin etevyys pelissä, tai sen toteutuksen virheettömyys eivät yksin riitä tekemään siitä uskottavaa. Tutkielmassa esitellään myös tekotyperyyden käsite. Tekotyperä agentti on tarkoituksellisesti ohjelmoitu tekemään virheitä. Tekstissä havainnollistetaan, kuinka tekotyperyys voi parantaa agentin uskottavuutta.
Assessing Personality in SLA: Type- and Trait-Focused Approaches
2022
The study of personality has long been one of the major themes in Psychology. Nevertheless, within the field of Second Language Acquisition (SLA), this research area has not received a lot of recognition, despite the strong ties of both disciplines. The objective of this paper is to describe the concept of personality and its role within the SLA field, as well as to outline the dominating research methodologies that are based on distinctive theoretical approaches. For this purpose, in Section 1 of the paper, the basic term of personality is defined, and its role in the process of foreign language acquisition is described, together with an outline of the most frequent problems encountered in…
Is HLA type a possible cancer risk modifier in Lynch syndrome?
2022
Lynch syndrome (LS) is the most common inherited cancer syndrome. It is inherited via a monoallelic germline variant in one of the DNA mismatch repair (MMR) genes. LS carriers have a broad 30-80% risk of developing various malignancies, and more precise, individual risk estimations would be of high clinical value, allowing tailored cancer prevention and surveillance. Due to MMR deficiency, LS cancers are characterized by the accumulation of frameshift mutations leading to highly immunogenic frameshift peptides (FSPs). Thus, immune surveillance is proposed to inhibit the outgrowth of MMR-deficient cell clones. Recent studies have shown that immunoediting during the evolution of MMR-deficient…
Visión directiva y elección estratégica: su influencia en los tipos básicos de trabajo
2008
Este trabajo analiza si la perspectiva de la elección estratégica (strategic choice) contribuye, más allá de los planteamientos de la teoría contingente, a la generación y descripción de distintos tipos básicos de trabajo. El análisis de las hipótesis formuladas, mediante un estudio de carácter cuantitativo, muestra que las variables que principalmente explican las diferencias entre los tipos de trabajo (y que caracterizan la perspectiva de la elección estratégica) son aquellas que se refieren a la percepción del entorno, en particular las que miden su grado de complejidad y dinamismo. En un menor grado, la variable estilo de liderazgo emprendedor influye también en la definición de las car…
Induction of body weight loss through RNAi-knockdown of APOBEC1 gene expression in transgenic rabbits
2014
In the search of new strategies to fight against obesity, we targeted a gene pathway involved in energy uptake. We have thus investigated the APOB mRNA editing protein (APOBEC1) gene pathway that is involved in fat absorption in the intestine. The APOB gene encodes two proteins, APOB100 and APOB48, via the editing of a single nucleotide in the APOB mRNA by the APOBEC1 enzyme. The APOB48 protein is mandatory for the synthesis of chylomicrons by intestinal cells to transport dietary lipids and cholesterol. We produced transgenic rabbits expressing permanently and ubiquitously a small hairpin RNA targeting the rabbit APOBEC1 mRNA. These rabbits exhibited a moderately but significantly reduced …
Ohjauksen kirjaaminen : tyypin 2 diabetespotilaiden omahoito ja osaaminen potilasasiakirjoissa
2017
The purpose of this study was to describe the contents of type 2 diabetes patient self-management counselling documentation, how counselling of self- management appeared in various content areas and how patients’ self- management competence developed during the counselling. The research data consisted of nurses’ documentations from type 2 diabetes patient self- management counselling situations (N = 60) in primary health care. The data was collected in 2014 from the period between the years 2005 and 2014. Data were analyzed using content analysis as well as a case study approach. The documentation of self-management counselling included entries from content areas on nutrition, exercise, wei…
Beneficial coinfection can promote within-host viral diversity
2018
Abstract In many viral infections, a large number of different genetic variants can coexist within a host, leading to more virulent infections that are better able to evolve antiviral resistance and adapt to new hosts. But how is this diversity maintained? Why do faster-growing variants not outcompete slower-growing variants, and erode this diversity? One hypothesis is if there are mutually beneficial interactions between variants, with host cells infected by multiple different viral genomes producing more, or more effective, virions. We modelled this hypothesis with both mathematical models and simulations, and found that moderate levels of beneficial coinfection can maintain high levels o…