Search results for "Type"

A Novel Border Identification Algorithm Based on an “Anti-Bayesian” Paradigm

2013

Published version of a chapter in the book: Computer Analysis of Images and Patterns. Also available from the publisher at: http://dx.doi.org/10.1007/978-3-642-40261-6_23 Border Identification (BI) algorithms, a subset of Prototype Reduction Schemes (PRS) aim to reduce the number of training vectors so that the reduced set (the border set) contains only those patterns which lie near the border of the classes, and have sufficient information to perform a meaningful classification. However, one can see that the true border patterns (“near” border) are not able to perform the task independently as they are not able to always distinguish the testing samples. Thus, researchers have worked on thi…

Rough Set Theory for Optimization of Packet Management Mechanism in IP Routers

2020

Bandwidth and consequently optimum overall efficiency of network system relies greatly on mechanism of packet management in IP routers. Our research objective is to implement rough set theory to minimizing number of the network system attributes responsible for decision making in selection of those packets, which improve its transmission. Such an approach is called priority queuing system model, as we assign priority to the packets selected, following rough set theory. Regardless of the file format, for all the routers, packets are transmitted in sequence one-by-one. Nonetheless, quality of streaming data largely depends on how much the packet loss is minimized, or eliminated at all, if pos…

Combined column-and-row-generation for the optimal communication spanning tree problem

2018

Abstract This paper considers the exact solution of the optimal communication spanning tree problem (OCSTP), which can be described as follows: Given an undirected graph with transportation costs on every edge and communication requirements for all pairs of vertices, the OCSTP seeks for a spanning tree that minimizes the sum of the communication costs between all pairs of vertices, where the communication cost of a pair of vertices is defined as their communication requirement multiplied by the transportation cost of the unique tree path that connects the two vertices. Two types of compact formulations for OCSTP were presented in the literature. The first one is a four-index model based on …

The ELECTRE I method to support the FMECA

2018

Abstract In traditional Failure Modes, Effects and Criticality Analysis (FMECA), risk priorities of failure modes are determined through the Risk Priority Number (RPN), which is a function of the three risk parameters Occurrence (O), Severity (S), and Detection (D). In the present paper, an alternative approach to RPN is proposed for the criticality assessment of system failure modes. Particularly, the Multi-Criteria Decision Making (MCDM) method ELECTRE I is proposed to select the most critical failure mode in the set of the failure modes charactering a complex system. The method has been applied to a case study previously proposed by Zammori and Gabrielli (2012).

2019

Integral membrane proteins of the aquaporin family facilitate rapid water flux across cellular membranes in all domains of life. Although the water-conducting pore is clearly defined in an aquaporin monomer, all aquaporins assemble into stable tetramers. In order to investigate the role of protomer–protomer interactions, we analyzed the activity of heterotetramers containing increasing fractions of mutated monomers, which have an impaired oligomerization propensity and activity. In order to enforce interaction between the protomers, we designed and analyzed a genetically fused homotetramer of GlpF, the aquaglyceroporin of the bacterium Escherichia coli (E. coli). However, increasing fractio…

Investigation of Isoindolo[2,1-a] quinoxaline-6-imines as Topoisomerase I Inhibitors with Molecular Modeling Methods

2017

Background: Isoindolo[2,1-alpha] quinoxalines constitute an important class of compounds which demonstrated potent antiproliferative activity against different human tumor cell lines and topoisomerase I inhibitors. In particular, their water soluble imine or iminium salts recently synthesized showed potent growth inhibitory effect on NCI-60 tumor cell line panel and biological studies performed on the most active compounds demonstrated that they cause DNA damage via topoisomerase I poisoning. Objective: Herein, we investigate with molecular modeling methods, the common features responsible for topoisomerase I inhibition of the water-soluble isoindolo[2,1-alpha] quinoxalin-6-imines, by compa…

Neither Diplectanum nor specific: a dramatic twist to the taxonomic framework of Diplectanum (Monogenea: Diplectanidae).

2019

The taxonomy of the genus Diplectanum has been exclusively based on morphological features, with 28 nominal species parasitic on perciform fishes recognised. We used molecular data, to our knowledge for the first time, to evaluate the taxonomic framework of Diplectanum, infer the relationships amongst species attributed to this genus, re-assess the degree of host specificity and explore the population genetic structure of Diplectanum spp. parasitising Mediterranean sciaenids, which are potential target fish species for aquaculture diversification in the region. A minimum of 10 specimens of Diplectanum spp. were sequenced per host species (Argyrosomus regius, Sciaena umbra, Umbrina canariens…

Exposure to a Highly Caloric Palatable Diet During Pregestational and Gestational Periods Affects Hypothalamic and Hippocampal Endocannabinoid Levels…

2016

Journal Article; Exposure to unbalanced diets during pre-gestational and gestational periods may result in long-term alterations in metabolism and behavior. The contribution of the endocannabinoid system to these long-term adaptive responses is unknown. In the present study, we investigated the impact of female rat exposure to a hypercaloric-hypoproteic palatable diet during pre-gestational, gestational and lactational periods on the development of male offspring. In addition, the hypothalamic and hippocampal endocannabinoid contents at birth and the behavioral performance in adulthood were investigated. Exposure to a palatable diet resulted in low weight offspring who exhibited low hypotha…

Effect of resource availability on evolution of virulence and competition in an environmentally transmitted pathogen

2018

Understanding ecological and epidemiological factors driving pathogen evolution in contemporary time scales is a major challenge in modern health management. Pathogens that replicate outside the hosts are subject to selection imposed by ambient environmental conditions. Increased nutrient levels could increase pathogen virulence by pre-adapting for efficient use of resources upon contact to a nutrient rich host or by favouring transmission of fast-growing virulent strains. We measured changes in virulence and competition in Flavobacterium columnare, a bacterial pathogen of freshwater fish, under high and low nutrient levels. To test competition between strains in genotype mixtures, we devel…

Human ectonucleotidase-expressing CD25 high Th17 cells accumulate in breast cancer tumors and exert immunosuppressive functions

2015

IF 7.644; International audience; Th17 cells contribute to the development of some autoimmune and allergic diseases by driving tissue inflammation. However, the function of Th17 cells during cancer progression remains controversial. Here, we show that human memory CD25(high) Th17 cells suppress T cell immunity in breast cancer. Ectonucleotidase-expressing Th17 cells accumulated in breast cancer tumors and suppressed CD4(+) and CD8(+) T cell activation. These cells expressed both Ror gamma t and Foxp3 genes and secreted Th17 related cytokines. We further found that CD39 ectonucleotisase expression on tumor-infiltrating Th17 cells was driven by TGF-beta and IL-6. Finally, immunohistochemical …