Search results for "UIC"
showing 10 items of 929 documents
Use of a logistic model to assess spoilage by Byssochlamys fulva in clarified apple juice
2010
Abstract The percentage P (%) of spoiled bottles (n = 40) of clarified apple juice due to Byssochlamys fulva, was modeled by using a logistic model: P = P max 1 + exp ( k ( τ − t ) ) where Pmax (%) the maximum percentage of spoiled bottles, k (h− 1) a slope parameter and τ (h) the time for P = Pmax/2. Bottles of pasteurized apple juice were inoculated with B. fulva IOC 4518 ascospores for low and high initial loads, 4.8 ± 2.3 ascospores/100 mL and 19.3 ± 4.6 ascospores/100 mL respectively and incubated at 21 °C and 30 °C. Pmax was not significantly different from 100% except for a low initial load at 21 °C. Model parameters were estimated with a good accuracy, RMSE in the range 3.89–7.50. T…
Preliminar construction of a multidimensional scale to assess clinical symptoms of anxiety. Evidences of content and face validity
2017
La medición de la ansiedad debería contemplar la multidimensionalidad de este constructo. Los instrumentos de uso local presentan limitaciones relacionadas con su abordaje incompleto, el contenido de sus ítems, la capacidad para discriminar los síntomas ansiosos de los depresivos y la desactualización con respecto a los diagnósticos vigentes. Un instrumento que tome en cuenta la conceptualización multidimensional de ansiedad y los criterios diagnósticos para el trastorno de ansiedad según la última versión del Manual de Diagnóstico y Estadístico de los Trastornos Mentales (DSM-5; American Psychiatric Association, 2013) podría responder a las limitaciones de sus predecesores. L…
Fluxapyroxad Haptens and Antibodies for Highly Sensitive Immunoanalysis of Food Samples
2017
Fluxapyroxad is a new-generation carboxamide fungicide, with residues increasingly being found in food samples. Immunochemical assays have gained acceptance in food quality control as rapid, cost-effective, sensitive, and selective methods for large sample throughput and in situ applications. In the present study, immunoreagents to fluxapyroxad were obtained for the first time, and competitive immunoassays were developed for the sensitive and specific determination of fluxapyroxad residues in food samples. Two carboxyl-functionalized analogues of fluxapyroxad were prepared, and antibodies with IC50 values in the low nanomolar range were generated from both haptens, though a dissimilar respo…
De ediciones y correcciones: Ibn Sāhib al-Salā, Cofrentes y la ruta antigua del río Magro
2008
Ledo Caballero, Antonio C. - Antonio.Ledo@uv.es En 1969, Ambrosio Huici publicó la versión en castellano del al-Mann bi-l-Imāma de Ibn Sāhib al- Salā. En la traducción se identifica un lugar, consignado en la fuente árabe como “Confluencia de los ríos”, con la localidad valenciana de Cofrentes. En el presente artículo intento demostrar lo incorrecto de esta identificación y propongo, a partir de la existencia de una antigua ruta que sigue el curso del río Magro y los datos de distancias ofrecidos por Ibn Salā, su reducción a un paraje ubicado entre las localidades de Requena y Yátova (Valencia). In 1969, Ambrosio Huici published the Spanish translation of al-Mann bi-l-Imāma, by Ibn Sāhib al…
Plant sterol oxides in functional beverages: Influence of matrix and storage
2014
Three plant sterol (PS)-enriched beverages, milk based fruit juice (MFJPS), fruit juice (FJPS) and milk beverage (MPS), were stored at 4, 24, or 37 °C and analysed at regular time intervals of 2 months until 6 months. PS stability was analysed from the production of phytosterol oxidation products (POPs). The β-sitosterol oxides (7α/7β-hydroxy, β/α-epoxy, triol, and 7-keto) and campesterol oxides (β/α-epoxy, and 7-keto) were detected in all beverages and at all storage times and temperatures. Total POP contents followed the order MPS≫FJPSMFJPS. In general, the beverages showed low PS oxidation levels (0.17%). Predictive models of POP content versus storage time were established. These models…
Cytotoxic effects of chemotherapy on cancer and immune cells: how can it be modulated to generate novel therapeutic strategies?
2015
The first objective to use chemotherapy is to kill cancer cells. However, it is common knowledge that these drugs can also damage healthy host cells, especially immune cells, and thus impair the endogenous antitumor response. Here, we focus on the cytotoxic effects of chemotherapy on tumor cells and immune cells. It is not enough to simply kill cancer cells, and causing immunogenic cell death will impair the adaptive immune system's ability to fight the remaining cancer cells. On the other hand, the killing of immune cells can also enhance tumor growth. A study of the repercussions of the cytotoxic effects of chemotherapy is of great importance to evaluate the antitumor response. Strategie…
Molecular principles of cancer invasion and metastasis (Review)
2009
The main threat and the reason for most cancer deaths are not the primary neoplasias, but secondary tumors, the metastases. Drastic phenotypic and biochemical changes occur during the metamorphosis of a normal tissue cell into an invasive cancer cell. These alterations concern various areas such as growth factor signaling, cell-cell adhesion, gene expression, motility or cell shape. Cancer cells of epithelial origin can even shed their typical qualities and characteristics and adopt a mesenchymal-like phenotype. This is often referred to as an epithelial-mesenchymal transition. Various oncogenes, tumor suppressor genes and metastasis suppressor genes are known to affect the invasiveness and…
Ganciclovir-induced apoptosis in HSV-1 thymidine kinase expressing cells: critical role of DNA breaks, Bcl-2 decline and caspase-9 activation.
2002
Although ganciclovir (GCV) is most often used in suicide anticancer gene therapy, the mechanism of GCV-induced cell killing and apoptosis is not fully understood. We analysed the mechanism of apoptosis triggered by GCV using a model system of CHO cells stably transfected with HSV-1 thymidine kinase (HSVtk). GCV-induced apoptosis is due to incorporation of the drug into DNA resulting in replication-dependent formation of DNA double-strand breaks and, at later stages, S and G2/M arrest. GCV-provoked DNA instability was likely to be responsible for the observed initial decline in Bcl-2 level and caspase-9/-3 activation. Further decline in the Bcl-2 level was due to cleavage of the protein by c…
Loneliness predicts suicidal ideation and anxiety symptoms in long-term childhood cancer survivors.
2020
Abstract Background/Objective Long-term childhood cancer survivors (CCS) are at risk for adverse late effects. However, not all of them are well understood. The present study addressed loneliness, a previously under-researched mental health risk in cancer survivor populations. We assessed the prevalence of loneliness and its impact on psychological symptoms over time. Method: A registry-based sample of N = 633 adult long-term CCS underwent medical and psychological assessments and took part in a follow-up survey 2.5 years later. Psychological symptoms (somatic, anxiety, depression symptoms, and suicidal ideation) were measured using the Patient Health Questionnaire. We calculated linear reg…
De Bernardo Ares José Manuel (coordinador), El Cardenal Portocarrero y su tiempo (1635-1709). Biografías estelares y procesos influyentes, León, CSED…
2013
El volumen, editado por José Manuel De Bernardo Ares, catedrático de Historia moderna de la Universidad de Córdoba, incluye los trabajos que fueron expuestos y debatidos en las V Jornadas de Historia “Cardenal Portocarrero”, que se celebró en el 2009 en Palma del Río (Córdoba) en ocasión del tercer centenario de la muerte del cardenal Luis Fernández Portocarrero. El volumen se divide en dos grandes partes: la primera trata ampliamente de la biografía personal y de las redes familiares y clientelares de Portocarrero; la segunda se centra en las influencias que las decisiones tomadas entre los siglos XVII y XVIII tuvieron en la cultura, en la sociedad, en la política y en la economía.