Search results for "ULB"
showing 10 items of 219 documents
Young neurons from medial ganglionic eminence disperse in adult and embryonic brain.
1999
In this study, we identified neuronal precursors that can disperse through adult mammalian brain tissue. Transplanted neuronal precursors from embryonic medial ganglionic eminence (MGE), but not from lateral ganglionic eminence (LGE) or neocortex, dispersed and differentiated into neurons in multiple adult brain regions. In contrast, only LGE cells were able to migrate efficiently from the adult subventricular zone to the olfactory bulb. In embryonic brain slices, MGE cells migrated extensively toward cortex. Our results demonstrate that cells in different germinal regions have unique migratory potentials, and that adult mammalian brain can support widespread dispersion of specific populati…
Determining the efficiency of optical sources using a smartphone's ambient light sensor
2017
This work reports the use of a smartphone’s ambient light sensor as a valuable tool to study and characterize the efficiency of an optical source. Here, we have measured both luminous efficacy and efficiency of several optical sources (incandescent bulb and halogen lamp) as a function of the electric power consumed and the distance to the optical detector. The illuminance of LEDs as a function of the distance to the optical detector is characterized for different wavelength emissions. Analysis of the results confirms an inverse-square law of the illuminance with the detector–source distance and shows good agreement with values obtained by classical experiments. This experience will trigger …
Novel NG2-CreERT2 knock-in mice demonstrate heterogeneous differentiation potential of NG2 glia during development
2014
NG2 (nerve/glia antigen-2) is a type I transmembrane glycoprotein and also known as chondroitin sulfate proteoglycan 4. In the parenchyma of the central nervous system, NG2-expressing (NG2(+) ) cells have been identified as a novel type of glia with a strong potential to generate oligodendrocytes (OLs) in the developing white matter. However, the differentiation potential of NG2 glia remained controversial, largely attributable to shortcomings of transgenic mouse models used for fate mapping. To minimize these restrictions and to more faithfully mimic the endogenous NG2 expression in vivo, we generated a mouse line in which the open reading frame of the tamoxifen-inducible form of the Cre D…
Fatal neuroinvasion and SARS-CoV-2 tropism in K18-hACE2 mice is partially independent on hACE2 expression
2022
ABSTRACTAnimal models recapitulating distinctive features of severe COVID-19 are critical to enhance our understanding of SARS-CoV-2 pathogenesis. Transgenic mice expressing human angiotensin-converting enzyme 2 (hACE2) under the cytokeratin 18 promoter (K18-hACE2) represent a lethal model of SARS-CoV-2 infection. The precise mechanisms of lethality in this mouse model remain unclear. Here, we evaluated the spatiotemporal dynamics of SARS-CoV-2 infection for up to 14 days post-infection. Despite infection and moderate pneumonia, rapid clinical decline or death of mice was invariably associated with viral neuroinvasion and direct neuronal injury (including brain and spinal neurons). Neuroinv…
In silico identification and experimental validation of hits active against KPC-2 β-lactamase
2018
Bacterial resistance has become a worldwide concern, particularly after the emergence of resistant strains overproducing carbapenemases. Among these, the KPC-2 carbapenemase represents a significant clinical challenge, being characterized by a broad substrate spectrum that includes aminothiazoleoxime and cephalosporins such as cefotaxime. Moreover, strains harboring KPC-type β-lactamases are often reported as resistant to available β-lactamase inhibitors (clavulanic acid, tazobactam and sulbactam). Therefore, the identification of novel non β-lactam KPC-2 inhibitors is strongly necessary to maintain treatment options. This study explored novel, non-covalent inhibitors active against KPC-2, …
Adult Neurogenesis in Reptiles
2011
Adult neurogenesis in reptiles is a well-documented phenomenon and exists in many telencephalic areas. The newly generated neurons originate along the walls of the lateral ventricles, mainly in the sulci. The putative neural progenitors are radial glial cells. These glial cells give rise to neuroblasts that migrate to their final destination. In general, the new neurons are born in the portion of the ventricular zone (VZ) adjacent to the telencephalic area where they will be recruited and migrate radially through the brain parenchyma along the processes of radial glial cells to their final destination, although migration to the olfactory bulbs (OB) is different. Specifically, it seems that …
Dendritic pattern development of the honeybee antennal lobe neurons: a laser scanning confocal microscopic study
1999
The processing of odorant signals is performed, in the olfactory bulb of vertebrates or in the antennal lobe of insects, by different types of neurons which display specific morphological and functional features. The present work characterizes the morphogenesis of the main neuronal types which participate in olfactory discrimination in the adult honeybee (Apis mellifera). Neurons were stained intracellularly with Lucifer yellow at different stages of pupal development and in the adult, and imaged by laser scanning confocal microscopy. Attending to branching patterns, all pupal neurons could be attributed to morphological types previously established in the adult. Given the functional import…
Gulbenes novada domes reprezentācija reģionālajā laikrakstā “Dzirkstele” un pašvaldības informatīvajā izdevumā “Gulbenes Novada Ziņas” 2019. gadā
2020
Bakalaura darba tēma ir “Gulbenes novada domes reprezentācija reģionālajā laikrakstā “Dzirkstele” un pašvaldības informatīvajā izdevumā “Gulbenes Novada Ziņas” 2019. gadā” Darba mērķis ir noskaidrot, kā Gulbenes novada domes un pašvaldības reprezentācija atšķiras novadu aprakstošajos medijos: reģionālajā laikrakstā “Dzirkstele” un pašvaldības informatīvajā izdevumā “Gulbenes Novada Ziņas”. Teorētiskajā daļā ir aplūkota teorija par reprezentāciju un valodas nozīmi reprezentācijā, par plašsaziņas līdzekļu ētikas principiem, pašiem plašsaziņas līdzekļiem, laikrakstiem un reģionālo presi. Darbā izmantotās pētījuma metodes ir kontentanalīze, diskursa analīze un aptaujas metode. Bakalaura darbā v…
Utilization of mulberry leaves (Morus latifolia cv. Kokusou 21) in diets for dairy ewes
2009
Twelve Valle del Belice lactating ewes were divided into three homogeneous groups and fed ad libitum the following diets in a 3 x 3 Latin square design: sulla hay (HA); sulla hay and Mulberry leaves (M. leaves) (HM); M. leaves (MU). DM intake of MU ewes was lower than that of HM ewes, with an intermediate level for HA ewes. HM ewes showed to prefer M. leaves to hay, but their need to balance the high protein and low NDF contents of M. leaves by eating hay also emerged. Milk yield increased as the dietary content of M. leaves increased- In addition, the use of HM and MU diets led to higher milk fat and urea content in comparison with the HA diet. The results confirmed that M. leaves are a su…
Un vocabulari pornogràfic francès-català inèdit
2014
Resum: Antoni Bulbena Tosell és autor d’un manuscrit, i inèdit, vocabulari pornogràfic francès-català català-francès, la Flora pornogràfica francesa: suplement al argot francès / Flore pornographique catalane: supplément à l’argot catalan. És una obra d’aproximadament l’any 1921 que, per la seva temàtica, ell mateix reservava per a no publicar-se. Bulbena és autor d’una discutida obra lingüística, entre la qual trobem diferents diccionaris, alguns d’ells entre el català i el francès. El darrer que publicà és el Diccionari de les lléngues francesa & catalana / Dictionnaire catalan-français (1921) que inclou dos apèndixs, un «Vocabulari d’argot francès» i un «Vocabulari d’argot catalan». …