Search results for "ULN"
showing 10 items of 1078 documents
Responses to vulnerability : care ethics and the technologisation of eldercare
2020
This article argues for a re-conceptualisation of care relations and uses the re-conceptualisation to scrutinise the way in which technology is adopted in eldercare practices. First, it draws on the definition of care as attentiveness to vulnerability, as used in the tradition of care ethics. Second, it specifies four essential aspects of care relations: relationality, dyadic mutuality, corporeality and devotion. Third, using socio-technical and phenomenological perspectives, care relations are contrasted with the idea of intertwining technological and human actors in care practices. Finally, using two adaptations of telecare as examples, the essential aspects of care relations are shown to…
Mathematical modeling of fetal limb growth
1989
Using ultrasound measurements of the femur, tibia, humerus, radius (N = 515), and fibula and ulna (N = 385) from normal fetuses between 12 and 40 completed weeks of gestation, growth models were determined for each bone by computer analysis. On the basis of residual analysis, growth of fetal limb bones could best be expressed as a function of tangens hyperbolicus. Growth profiles and growth data are shown with 5th, 10th, 50th, 90th, and 95th percentiles. These results are compared with previous investigations of limb bone measurements.
Role of the metalloprotease Vvp and the virulence plasmid pR99 of Vibrio vulnificus serovar E in surface colonization and fish virulence.
2007
The virulence for eels of Vibrio vulnificus biotype 2 serovar E (VSE) is conferred by a plasmid that codifies ability to survive in eel serum and cause septicaemia. To find out whether the plasmid and the selected chromosomal gene vvp plays a role in the initial steps of infection, the VSE strain CECT4999, the cured strain CT218 and the Vvp-deficient mutant CT201 (obtained in this work by allelic exchange) were used in colonization and virulence experiments. The eel avirulent biotype 1 (BT1) strain YJ016, whose genome has been sequenced, was used for comparative purposes. The global results demonstrate that the plasmid does not play a significant role in surface colonization because (i) CEC…
A comparative epizootiologic study of the two fish-pathogenic serovars ofVibrio vulnificusbiotype 2
2010
Vibrio vulnificus biotype 2 is subdivided into two main serovars, serovar E, able to infect fish and humans, and serovar A, only virulent for fish. Serovar E emerged in 1976 as the causative agent of a haemorrhagic septicaemia (warm-water vibriosis) affecting eels cultured in brackish water. Serovar A emerged in 2000 in freshwater-cultured eels vaccinated against serovar E, causing warm-water vibriosis with fish showing a haemorrhagic intestine as the main differential sign. The aim of the present work was to compare the disease caused by both serovars in terms of transmission routes, portals of entry and host range. Results of bath, patch-contact and oral-anal challenges demonstrated that …
An Enriched European Eel Transcriptome Sheds Light upon Host-Pathogen Interactions with Vibrio vulnificus.
2015
Infectious diseases are one of the principal bottlenecks for the European eel recovery. The aim of this study was to develop a new molecular tool to be used in host-pathogen interaction experiments in the eel. To this end, we first stimulated adult eels with different pathogen- associated molecular patterns (PAMPs), extracted RNA from the immune-related tissues and sequenced the transcriptome.We obtained more than 2x106 reads that were assembled and annotated into 45,067 new descriptions with a notable representation of novel transcripts related with pathogen recognition, signal transduction and the immune response. Then, we designed a DNA-microarray that was used to analyze the early immun…
Early steps in the European eel (Anguilla anguilla)–Vibrio vulnificus interaction in the gills: Role of the RtxA13 toxin
2015
Vibrio vulnificus is an aquatic gram-negative bacterium that causes a systemic disease in eels called warm-water vibriosis. Natural disease occurs via water born infection; bacteria attach to the gills (the main portal of entry) and spread to the internal organs through the bloodstream, provoking host death by haemorrhagic septicaemia. V.vulnificus produces a toxin called RtxA13 that hypothetically interferes with the eel immune system facilitating bacterial invasion and subsequent death by septic shock. The aim of this work was to study the early steps of warm-water vibriosis by analysing the expression of three marker mRNA transcripts related to pathogen recognition (tlr2 and tlr5) and in…
Transmission to Eels, Portals of Entry, and Putative Reservoirs of Vibrio vulnificus Serovar E (Biotype 2)
2001
ABSTRACT Vibrio vulnificus serovar E (formerly biotype 2) is the etiologic agent that is responsible for the main infectious disease affecting farmed eels. Although the pathogen can theoretically use water as a vehicle for disease transmission, it has not been isolated from tank water during epizootics to date. In this work, the mode of transmission of the disease to healthy eels, the portals of entry of the pathogen into fish, and their putative reservoirs have been investigated by means of laboratory and field experiments. Results of the experiments of direct and indirect host-to-host transmission, patch contact challenges, and oral-anal intubations suggest that water is the prime vehicle…
Giustizia penale e tratta di esseri umani: i risvolti processuali della "vulnerabilità"
2017
Il contrasto dei fenomeni di tratta e di traffico di esseri umani mostra un processo di “contaminazione” fra normativa di tipo universale e regionale, caratterizzato dal rispetto dello standard di Duty of Due Diligence. Domina lo scenario italiano il concetto polifunzionale di “vulnerabilità”, direttamente trasfuso nella fattispecie sostanziale, recepito nel sistema processuale ed evidenziato da alcuni esiti giurisprudenziali. Esso, oltre a influenzare la determinazione del locus commissi delicti, gioca un ruolo di sicuro rilievo nel giustificare forme di anticipazione del contraddittorio e nel tratteggiare i contorni della prova dichiarativa “debole”. Ulteriori effetti la “vulnerabilità” e…
The Risk Society: Towards a new modernity
2009
The present review discusses one of the pioneer projects authored by Ulrich Beck, regarding risk perception issues, which was originally titled Risikogesellshaft, Auf dem weg in eine andere Moderne or in English The society of risk, towards a new modernity. This review is part of a broader project related to a Social Psychology doctoral thesis on fears of travelling in urban circumstances.
Derecho antidiscriminatorio y protección de los colectivos en situación de vulnerabilidad en las constituciones de Ecuador de 2008 y de Bolivia de 20…
2019
El sujeto político que protagonizó los procesos constituyentes de Bolivia y Ecuador no estaba conformado por un partido obrero clásico sino por la agregación de múltiples movimientos o luchas de grupos en situación de vulnerabilidad. Esta naturaleza del sujeto constituyente determinó que la forma de constitucionalismo social emergente no se basara, como el europeo, en la subjetivación del trabajo y reconocimiento de derechos vinculados al trabajosalario, sino en la visibilización de los grupos sociales hasta ahora excluidos y en su inclusión a la ciudadanía. Ello explica que se traten de textos muy ricos en referencias y mecanismos para el reconocimiento y garantía de los derechos específic…