Search results for "URACIL"
showing 10 items of 343 documents
TRAIL-induced apoptosis of hepatocellular carcinoma cells is augmented by targeted therapies
2009
AIM: To analyze the effect of chemotherapeutic drugs and specific kinase inhibitors, in combination with the death receptor ligand tumor necrosis factor-related apoptosis inducing ligand (TRAIL), on overcoming TRAIL resistance in hepatocellular carcinoma (HCC) and to study the efficacy of agonistic TRAIL antibodies, as well as the commitment of antiapoptotic BCL-2 proteins, in TRAIL-induced apoptosis. METHODS: Surface expression of TRAIL receptors (TRAIL-R1-4) and expression levels of the antiapoptotic BCL-2 proteins MCL-1 and BCL-xL were analyzed by flow cytometry and Western blotting, respectively. Knock-down of MCL-1 and BCL-xL was performed by transfecting specific small interfering RNA…
CCDC 120949: Experimental Crystal Structure Determination
2000
Related Article: F.Hueso-Urena, M.N.Moreno-Carretero, A.L.Penas-Chamorro, J.M.Amigo, V.Esteve, T.Debaerdemaeker|1999|Polyhedron|18|3629|doi:10.1016/S0277-5387(99)00292-2
CCDC 236010: Experimental Crystal Structure Determination
2005
Related Article: E.Saniger, M.Diaz-Gavilan, B.Delgado, D.Choquesillo, J.M.Gonzalez-Perez, S.Aiello, M.A.Gallo, A.Espinosa, J.M.Campos|2004|Tetrahedron|60|11453|doi:10.1016/j.tet.2004.09.077
CCDC 119847: Experimental Crystal Structure Determination
2000
Related Article: F.Hueso-Urena, M.N.Moreno-Carretero, A.L.Penas-Chamorro, J.M.Amigo, V.Esteve, T.Debaerdemaeker|1999|Polyhedron|18|3629|doi:10.1016/S0277-5387(99)00292-2
CCDC 121426: Experimental Crystal Structure Determination
2000
Related Article: F.Hueso-Urena, M.N.Moreno-Carretero, A.L.Penas-Chamorro, J.M.Amigo, V.Esteve, T.Debaerdemaeker|1999|Polyhedron|18|3629|doi:10.1016/S0277-5387(99)00292-2
CCDC 1934514: Experimental Crystal Structure Determination
2019
Related Article: Verónica G. Vegas, Noelia Maldonado, Oscar Castillo, Carlos J. Gómez-García, Pilar Amo-Ochoa|2019|J.Inorg.Biochem.|200|110805|doi:10.1016/j.jinorgbio.2019.110805
CCDC 2064122: Experimental Crystal Structure Determination
2021
Related Article: Verónica G. Vegas, Ana Latorre, María Luisa Marcos, Carlos J. Gómez-García, Óscar Castillo, Félix Zamora, Jacobo Gómez, José Martínez-Costas, Miguel Vázquez López, Álvaro Somoza, Pilar Amo-Ochoa|2021|ACS Applied Materials and Interfaces|13|31|doi:10.1021/acsami.1c11612
CCDC 2064123: Experimental Crystal Structure Determination
2021
Related Article: Verónica G. Vegas, Ana Latorre, María Luisa Marcos, Carlos J. Gómez-García, Óscar Castillo, Félix Zamora, Jacobo Gómez, José Martínez-Costas, Miguel Vázquez López, Álvaro Somoza, Pilar Amo-Ochoa|2021|ACS Applied Materials and Interfaces|13|31|doi:10.1021/acsami.1c11612
Regioselectivity of the OH Radical Addition to Uracil in Nucleic Acids. A Theoretical Approach Based on QM/MM Simulations.
2017
Oxidation of nucleic acids is ubiquitous in living beings under metabolic impairments and/or exposed to external agents such as radiation, pollutants, or drugs, playing a central role in the development of many diseases mediated by DNA/RNA degeneration. Great efforts have been devoted to unveil the molecular mechanisms behind the OH radical additions to the double bonds of nucleobases; however, the specific role of the biological environment remains relatively unexplored. The present contribution tackles the study of the OH radical addition to uracil from the gas phase to a full RNA macromolecule by means of quantum-chemistry methods combined with molecular dynamics simulations. It is shown…
Analysis of the Thymidylate Synthase Gene Structure in Colorectal Cancer Patients and lts Possible Relation with the S-Fluorouracil Drug Response
2010
Thymidylate synthase (TS) catalyzes methylation of dUMP to dTMP and it is the target for the 5-Fluorouracil (5-FU) activity*. Barbour et al. showed that variant structural forms of TS in tumour cell lines confer resistance to fluoropyrimidines. We planned to perform the whole TS gene structure by means of sequencing techniques in human colorectal cancer (CRC) san-rples to try to identify the presence of any possible TS variant form that could be responsible of fluoropyrimidines drug resistance and of the worse prognosis. We performed the TS-DNA gene sequence in 68 CRC from patients of A, B, and C Dukes' stages and different histological grade, but we did not find any mutation in the TS-DNA …