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showing 10 items of 539 documents
Pathway network inference from gene expression data
2014
[EN] Background: The development of high-throughput omics technologies enabled genome-wide measurements of the activity of cellular elements and provides the analytical resources for the progress of the Systems Biology discipline. Analysis and interpretation of gene expression data has evolved from the gene to the pathway and interaction level, i.e. from the detection of differentially expressed genes, to the establishment of gene interaction networks and the identification of enriched functional categories. Still, the understanding of biological systems requires a further level of analysis that addresses the characterization of the interaction between functional modules. Results: We presen…
Diurnal habitat suitability for a Mediterranean steppeland bird, identified by Ecological Niche Factor Analysis
2011
Context The negative effects of agricultural intensification and policies, use of pesticides, fertilisers and mechanised harvesting on several populations of pseudo-steppe birds have increasingly required more detailed and effective habitat suitability models. Distribution models of farmland species are prone to incur recordings of false absence data. Ecological Niche Factor Analysis (ENFA) allows identification of environmental predictors of species distribution by using presence data only. Aims We quantified the diurnal habitat preferences and niche width of one steppe species, the stone curlew (Burhinus oedicnemus), with unfavourable conservations status in a Mediterranean area and recl…
Comprehensive database on Induan (Lower Triassic) to Sinemurian (Lower Jurassic) marine bivalve genera and their paleobiogeographic record
2014
Marine bivalve genera that were described or mentioned for Triassic and Lower Jurassic deposits worldwide are reviewed in terms of their validity, stratigraphic range, paleogeographic distribution, paleoautoecology and shell mineralogy. Data were originally compiled at species level and are arranged systematically. A brief discussion for each genus includes synonymy, taxonomic status and included subgenera, as well as current uncertainties about their validity and range. The distribution of each genus is also shown on paleogeographic maps. Type species and first and last appearances of each genus are also mentioned. We recognize as valid 280 genera and their included subgenera, and we furth…
Bases para el análisis económico de los sistemas de compliance penal
2019
Compliance programs and systems of criminal or administrative liability are being increasingly adopted by different countries as measures meant to reduce the social cost of white collar criminality. However, the legal application of these measures does not always ponder correctly the impacts on common good, the levels of economic activity and the adequate functioning of markets of goods and services. Eventually, this situation can lead to undesired effects, such as the inefficiency of the criminal system, the reduction of economic activity or the arising of obstacles to competition. By taking these circumstances into account, in this paper we will utilize the Economic Analysis of Law to ana…
Edizione critica di "No hay vida como la honra", in Mata Induráin, Carlos (ed.), "Comedias burlescas del Siglo de Oro", tomo VII, collezione Bibliote…
2011
L'edizione di "No hay vida como la honra" porta alla luce una commedia burlesca inedita ed anonima e si inquadra nel progetto di edizione del corpus completo delle commedie burlesche del Siglo de Oro portato avanti dal Grupo de Investigación Siglo de Oro (GRISO) della Universidad de Navarra. L'edizione è preceduta da uno studio critico che evidenzia le caratteristiche strutturali e tematiche dell'opera, le sue modalità burlesche, l’aspetto retorico, le sue relazioni con l’omonima commedia di Juan Pérez de Montalbán, della quale si rivela essere la parodia.
Uzturlīdzekļu pārrobežu piedziņas par labu nepilngadīgam bērnam problemātika
2021
Bakalaura darbs “Uzturlīdzekļu pārrobežas piedziņas par labu nepilngadīgam bērnam problemātika” ir vērsts uz aktuālo uzturlīdzekļu pārrobežu piedziņas jautājumu izpēti saistībā ar Uzturlīdzekļu Regulas piemērošanas aspektiem, identificējot problēmjautājumus un piedāvājot to risinājumu. Bakalaura darba saturs tiek balstīts uz juridiskās literatūras izpēti, Eiropas Savienības aktuālo tiesību instrumentu uzturlīdzekļu pārrobežu saistību jautājumu risināšanā izpēti un analīzi. Darba ietvaros tika identificēti dažādi ar uzturlīdzekļu pārrobežu piedziņu saistītie problēmjautājumi un sniegts to iespējamais risinājums. Bakalaura darbs sastāv no anotācijas latviešu un angļu valodā, trīs nodaļām, kop…
Improved fast Gauss transform for meshfree electromagnetic transients simulations
2019
Abstract In this paper improved fast summations are introduced to enhance a meshfree solver for the evolution of the electromagnetic fields over time. The original method discretizes the time-domain Maxwell’s curl equations via Smoothed Particle Hydrodynamics requiring many summations on the first derivatives of the kernel function and field vectors at each time step. The improved fast Gauss transform is properly adopted picking up the computational cost and the memory requirement at an acceptable level preserving the accuracy of the computation. Numerical simulations in two-dimensional domains are discussed giving evidence of improvements in the computation compared to the standard formula…
Experimental and theoretical insights in the alkene-arene intramolecular π-stacking interaction
2016
Chiral acrylic esters derived from biomass were developed as models to have a better insight in the aryl-vinyl π-stacking interactions. Quantum chemical calculations, NMR studies and experimental evidences demonstrated the presence of equilibriums of at least four different conformations: π-stacked and face-to-edge, each of them in an s-cis/s-trans conformation. The results show that the stabilization produced by the π-π interaction makes the π-stacked conformation predominant in solution and this stabilization is slightly affected by the electron density of the aromatic counterpart. Fil: Corne, Valeria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológi…
Ultra-fast direct growth of metallic micro- and nano-structures by focused ion beam irradiation
2019
An ultra-fast method to directly grow metallic micro- and nano-structures is introduced. It relies on a Focused Ion Beam (FIB) and a condensed layer of suitable precursor material formed on the substrate under cryogenic conditions. The technique implies cooling the substrate below the condensation temperature of the gaseous precursor material, subsequently irradiating with ions according to the wanted pattern, and posteriorly heating the substrate above the condensation temperature. Here, using W(CO)6 as the precursor material, a Ga+ FIB, and a substrate temperature of -100 °C, W-C metallic layers and nanowires with resolution down to 38 nm have been grown by Cryogenic Focused Ion Beam Indu…
Overexpression of the truncated form of high mobility group a proteins (HMGA2) in human myometrial cells induces leiomyoma-like tissue formation
2014
The pathogenesis of uterine leiomyomas, the most common benign tumor in women, is still unknown. This lack of basic knowledge limits the development of novel non-invasive therapies. Our group has previously demonstrated that leiomyoma side population (SP) cells are present in tumor lesions and act like putative tumor-initiating stemcells in human leiomyoma. Moreover, accumulated evidence demonstrates that these benign tumors of mesenchymal origin are characterized by rearrangements of the High Mobility Group A proteins (HMGA). In this work, we tested the hypothesis that leiomyoma development may be due to overexpression of HMGA2 (encoding high mobility group AT-hook2) in myometrial stem cel…