Search results for "Uber"
showing 10 items of 1027 documents
Cloning of sponge heat shock proteins: evolutionary relationships between the major kingdoms
2009
In the present study we have cloned from sponges (Porifera) those molecules which are involved in the protection of organisms against physiological and stress conditions; the inducible heat shock protein Mr 70,000, hsp70, from the marine sponge Geodia cydonium, its interacting hsp40, a DnaJ-like protein (from G. cydonium) and the constitutively expressed counterpart the glucose-regulated protein Mr 78,000, GRP78 from Suberites domuncula. Alignments of the sequences revealed that the deduced aa sequences of all sponge hsp's share high homology to other metazoan sequences, and are separated from related sequences from plants and fungi (hsp70, GRP78, DnaJ) as well as Bacteria (DnaK, the hsp70 …
Propuesta de política pública para acelerar la transición hacia el automóvil eléctrico en el contexto español
2018
Este trabajo pretende determinar el tipo de intervención pública deseable en España para acelerar la transición hacia una adopción mayoritaria del coche eléctrico. Para ello primero se tratará de explicar los efectos positivos de esta transición, la situación actual del mercado del coche eléctrico en España, las barreras que frenan una mayor penetración en el mercado y las iniciativas políticas en otros países en este tema. Y posteriormente haremos un repaso de los planes de estímulo a la adquisición de vehículos eléctricos en nuestro país estos tres últimos años. Observamos que en España la ciudadanía responde positivamente a unas políticas de incentivo al coche eléctrico que se han mostra…
Haploinsufficiency of Tsc2 Leads to Hyperexcitability of Medial Prefrontal Cortex via Weakening of Tonic GABAB Receptor-mediated Inhibition.
2020
Abstract Loss-of-function mutation in one of the tumor suppressor genes TSC1 or TSC2 is associated with several neurological and psychiatric diseases, including autism spectrum disorders (ASDs). As an imbalance between excitatory and inhibitory neurotransmission, E/I ratio is believed to contribute to the development of these disorders, we investigated synaptic transmission during the first postnatal month using the Tsc2+/− mouse model. Electrophysiological recordings were performed in acute brain slices of medial prefrontal cortex. E/I ratio at postnatal day (P) 15–19 is increased in Tsc2+/− mice as compared with wildtype (WT). At P25–30, facilitated GABAergic transmission reduces E/I rati…
Synthesis of the aggregation pheromone of the Colorado potato beetle from its degradation product
2015
Incubation of the Colorado potato beetle aggregation pheromone, (S)-1,3-dihydroxy-3,7-dimethyl-6-octen-2-one, with antennal or leg extracts from this beetle gave 6-methyl-5-hepten-2-one as the major product. This ketone was used as a substrate in a stereoselective synthesis of the pheromone. It was attached to the butanediacetal of glycolic acid with good stereoselectivity and the desired isomer was further enriched by purification of the product of this reaction on silica gel.
Laudatio (Investidura como Doctor "Honoris Causa" por la Universitat de València a José Vidal Beneyto)
2006
Fantasmas y Malentendidos
2001
Suicidio programado
2001
Sex pheromones are not always attractive: changes induced by learning and illness in mice
2014
A male-specific major urinary protein named darcin is attractive to female mice, Mus musculus, stimulates a learned attraction to volatile components of a male's urinary odour and induces spatial learning. In this article we show that darcin also induces learned attraction for a previously neutral olfactory stimulus (the odorant isoamyl acetate), acquired by repeated presentation of both stimuli together. We hypothesize that this is a case of olfactory–vomeronasal associative learning, in which darcin acts as the unconditioned reinforcer. However, the presence of darcin is not always attractive to adult female mice. Urine from males parasitized by the nematode Aspiculuris tetraptera has no …
Towards next generation diagnostics for tuberculosis: identification of novel molecular targets by large-scale comparative genomics
2019
AbstractTuberculosis remains one of the main causes of death worldwide. The long and cumbersome process of culturingMycobacterium tuberculosiscomplex (MTBC) bacteria has encouraged the development of specific molecular tools for detecting the pathogen. Most of these tools aim to become novel tuberculosis diagnostics, and big efforts and resources are invested in their development, looking for the endorsement of the main public health agencies. Surprisingly, no study had been conducted where the vast amount of genomic data available is used to identify the best MTBC diagnostic markers. In this work, we use large-scale comparative genomics to provide a catalog of 30 characterized loci that ar…