Search results for "Uber"
showing 10 items of 1027 documents
Dermatofibrosarcoma protuberans: estudio de factores pronósticos
2012
Introducción: El dermatofibrosarcoma protubernas (DFSP) es un tumor cutáneo de malignidad intermedia clasificado dentro de los tumores fibrohistiocíticos que tiene una alta tasa de recidivas locales tras extirpaciones con cirugía convencional pero baja capacidad de producir metástasis. Hipótesis: Existen determinadas características del DFSP que condicionan un crecimiento más infiltrativo, asimétrico e impredecible, lo que supone mayor morbilidad para el paciente y una mayor dificultad para su tratamiento. Objetivos: 1.-Realizar un análisis observacional y descriptivo de una serie de casos de DFSP que han sido vistos en el Servicio de Dermatología del IVO, según las características epidemio…
S-type lectins occur also in invertebrates: high conservation of the carbohydrate recognition domain in the lectin genes from the marine sponge Geodi…
1993
The marine sponge Geodia cydonium contains several lectins. The main component, called lectin-1, is composed of three to four identical subunits. The subunits of the lectins were cloned from a cDNA library; two clones were obtained. From the deduced aa sequence of one clone, LECT-1, a mol. wt of 15,313 Da is calculated; this value is in good agreement with mass spectrometric analysis of 15,453 +/- 25 Da. The sequence of another clone, LECT-2, was analysed and the aa sequence was deduced (15,433 Da). The two subunits have a framework sequence of 38 conserved aa which are characteristic for the carbohydrate-binding site of vertebrate S-type lectins. Clustering of lectin sequences of various s…
Longitudinal associations of physical activity and pubertal development with academic achievement in adolescents.
2020
Highlights • Boys with higher levels of moderate-to-vigorous physical activity had better academic achievement than those with lower levels of physical activity at baseline. • Physical activity was not associated with academic achievement at follow-up in boys or girls. • Continuously inactive adolescents had poorer academic achievement over the follow-up period than their more active peers. • Girls with more advanced pubertal status had better academic achievement than other girls.
As inovações em contabilidade governamental na américa latina: o caso da Colômbia
2012
En este trabajo se aborda la reforma de la contabilidad gubernamental en Colombia -iniciada en 1991 y que se extiende hasta la actualidad- buscando contribuir a la comprensión de la génesis y del desarrollo del Sistema Contable Público Colombiano. Un elemento novedoso reside en documentar parte del proceso de adaptación de las International Public Sector Accounting Standards, IPSAS, a un contexto específico. Así, la pregunta central del documento es: ¿Puede considerarse el proceso desarrollado en la contabilidad gubernamental en Colombia como una innovación? Desde un enfoque descriptivo y analítico, soportado en documentos públicos y en fuentes secundarias, los autores caracterizan lo acont…
Functional Assessment of Variants in the TSC1 and TSC2 Genes Identified in Individuals with Tuberous Sclerosis Complex
2011
The effects of missense changes and small in-frame deletions and insertions on protein function are not easy to predict, and the identification of such variants in individuals at risk of a genetic disease can complicate genetic counselling. One option is to perform functional tests to assess whether the variants affect protein function. We have used this strategy to characterize variants identified in the TSC1 and TSC2 genes in individuals with, or suspected of having, Tuberous Sclerosis Complex (TSC). Here we present an overview of our functional studies on 45 TSC1 and 107 TSC2 variants. Using a standardized protocol we classified 16 TSC1 variants and 70 TSC2 variants as pathogenic. In add…
Discours et genres rebelles.
2010
Decoding tuberculosis transmission and drug resistance in Valencia Region using whole genome sequencing
2020
La tuberculosis (TB) es una enfermedad infecciosa causada y transmitida por miembros patógenos que pertenecen al complejo de Mycobacterium tuberculosis (MTBC). En el 2018, la Organización Mundial de la Salud (OMS) estimó que 10 millones de personas se infectaron de TB, de los cuales, 1,45 millones de casos murieron a causa de esta. Con estos números, la TB es una de las diez principales causas de muerte en todo el mundo. La TB se transmite por el aire a través de gotas en aerosol generadas al toser por una persona contagiada, por lo que, el sitio de infección más común es el sistema respiratorio. La transmisión es la causa principal de TB en países de alta y baja incidencia. Por este motivo…
Medición para el cambio en entidades sociales: La elaboración de un Cuadro de Mando Integral
2022
Los cambios sociales y las demandas actuales evidencian la necesidad de que las organizaciones de la economía social setransformen con agilidad y con visión de futuro. Para lograrloy avanzar en el cumplimiento de los ODS, resulta clave el establecimiento de metas estratégicas y la medición de resultados. En este trabajo, se presenta el proceso de la construcción e implementación de un Cuadro de Mando Integral como herramienta de gestión y estrategia de acción social en la Federación Española de Fibrosis Quística, entidad sin ánimo de lucro del Tercer Sector de Acción Social. Se ha utilizado el método Delphi como herramienta de consenso, contando con la participación de catorce expertos con …
Hierarchical cross-scale analysis identifies parallel ventral striatal networks coding for dynamic and stabilized olfactory reward predictions
2021
SUMMARYThe unbiased identification of brain circuits responsible for behavior and their local cellular computations is a challenge for neuroscience. We establish here a hierarchical cross-scale approach from behavioral modeling and fMRI in task-performing mice to cellular network dynamics to identify how reward predictions are represented in the forebrain upon olfactory conditioning. fMRI identified functional segregation in reward prediction and error computations among olfactory cortices and subcortical circuits. Among them, the olfactory tubercle contributed both to dynamic reward predictions and prediction error. In this region, cellular recordings revealed two parallel neuronal populat…
Origin of the Metazoan Immune System: Identification of the Molecules and Their Functions in Sponges
2011
SYNOPSIS. During the evolutionary transition to Metazoa, cell-cell- as well as cell-matrix recognition molecules have been formed, which made a further step in evolution possible, the establishment of an immune system. Sponges [Porifera] represent the oldest still extant metazoan phylum and consequently testify to major features of the common metazoan ancestor, the Urmetazoa. Most studies with respect to evolution and phylogeny in sponges have been performed with the marine demosponges Suberites domuncula and Geodia cydonium. These animals possess effective defense systems against microbes and parasites which involve engulfment of bacteria into specific cells, but also signal transduction p…