Search results for "Uber"
showing 10 items of 1027 documents
Non-specific Effects of Vaccines Illustrated Through the BCG Example: From Observations to Demonstrations
2018
Epidemiological studies regarding many successful vaccines suggest that vaccination may lead to a reduction in child mortality and morbidity worldwide, on a grander scale than is attributable to protection against the specific target diseases of these vaccines. These non-specific effects (NSEs) of the Bacille Calmette-Guérin (BCG) vaccine, for instance, implicate adaptive and innate immune mechanisms, with recent evidence suggesting that trained immunity might be a key instrument at play. Collectively referring to the memory-like characteristics of innate immune cells, trained immunity stems from epigenetic reprogramming that these innate immune cells undergo following exposure to a primary…
IL-12 Expands and Differentiates Human Vγ2Vδ2 T Effector Cells Producing Antimicrobial Cytokines and Inhibiting Intracellular Mycobacterial Growth
2019
While IL-12 plays a key role in differentiation of protective CD4+ Th1 response, little is known about mechanisms whereby IL-12 differentiates other T-cell populations. Published studies suggest that predominant Vγ2Vδ2 T cells in humans/nonhuman primates (NHP) are a fast-acting T-cell subset, with capacities to rapidly expand and produce Th1 and cytotoxic cytokines in response to phosphoantigen (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMBPP) produced by Mycobacterium tuberculosis (Mtb) or others. However, whether IL-12 signaling pathway mediates fast-acting and Th1 or anti-microbial features of Vγ2Vδ2 T cells remains poorly defined. Here, we show that IL-12, but not other IL-12 fami…
γδ T Cells Cross-Link Innate and Adaptive Immunity in Mycobacterium tuberculosis Infection
2011
Protective immunity against mycobacterial infections such asMycobacterium tuberculosisis mediated by interactions between specific T cells and activated antigen presenting cells. To date, many aspects of mycobacterial immunity have shown that innate cells could be the key elements that substantially may influence the subsequent adaptive host response. During the early phases of infection, innate lymphocyte subsets play a pivotal role in this context. Here we summarize the findings of recent investigations onγδT lymphocytes and their role in tuberculosis immunity.
Functional Signatures of Human CD4 and CD8 T Cell Responses to Mycobacterium tuberculosis
2014
With 1.4 million deaths and 8.7 million new cases in 2011, tuberculosis (TB) remains a global health care problem and together with HIV and Malaria represents one of the three infectious diseases world-wide. Control of the global TB epidemic has been impaired by the lack of an effective vaccine, by the emergence of drug-resistant forms of Mycobacterium tuberculosis (Mtb) and by the lack of sensitive and rapid diagnostics. It is estimated, by epidemiological reports, that one third of the world's population is latently infected with Mtb, but the majority of infected individuals develop long-lived protective immunity, which controls and contains Mtb in a T cell-dependent manner. Development o…
Autonomy and Cooperation in Federalizing Models of Cultural Policy. Comparative Analysis of the Cases of Germany, USA, Canada, Switzerland, United Ki…
2018
Desde los años ochenta diversas investigaciones han profundizado en la comparación de los diversos modelos de las políticas culturales nacionales. Asimismo, el interés por la descentralización cultural y el reconocimiento de la diversidad cultural y nacional ha crecido en paralelo a la importancia de la acción cultural pública de las regiones y las municipalidades. Sin embargo, no se han desarrollado estudios que permitan comparar de forma sistemática la relación entre los modelos de federalismo y los modelos de política cultural de un Estado. Este trabajo persigue cubrir este vacío realizando una comparativa de seis países federales o casi federales que han destacado en su desarrollo de po…
Estudio de la distribución clonal de aislados clínicos de Mycobacterium tuberculosis complex mediante técnicas genotípicas en el área de influencia d…
2019
La tuberculosis sigue siendo un importante problema sanitario y de salud pública a escala mundial. Por esta razón se han establecido estrategias que contribuyen a mejorar los procesos de control y vigilancia de esta enfermedad, basadas en el estudio epidemiológico molecular del complejo Mycobacterium tuberculosis. En las últimas dos décadas han surgido múltiples técnicas de genotipificación aplicadas a este microorganismo, permitiendo discriminar el origen clonal de los aislados clínicos en distintos contextos. El objetivo principal de este estudio es la caracterización molecular de 154 aislados clínicos del complejo Mycobacterium tuberculosis en el Departamento de Salud Valencia - Hospital…
Détéction de Mycobacterium bovis dans les sols et la faune du sol
2011
Master 2 Aliments Microbiologie Assurance Qualité, option: Microbiologie appliquée à l'agro-alimentaire et à l'agro-environnement (Formation continue); Master
Książki poddane w 1841 r. cenzurze prewencyjnej. Przyczynek źródłowy do dziejów bibliotek klasztorów skasowanych na mocy ukazu z 1832 r. w guberniach…
2014
Mycobacterium tuberculosis multirezistences noteikšanas metodes
2019
Darba aktualitāte: Neskatoties uz to, ka šobrīd ir pieejami vairāki TB kontroles mehānismi gan slimības diagosticēšanai, gan ārstēšanai, un multirezistentās tuberkulozes prevalence samazinās, tā joprojām ir aktuāla problēma. Ņemot vērā, ka rezistence pret tuberkulozi dažādos reģionos krasi atškiras, svarīgi noskaidrot tās pašreizējo situāciju Latvijā un konkrētāk analizēt pret kuriem no anti-tuberkulozes medikamentiem reizistence ir sastopama visbiežāk. Darba mērķis: : Noteikt M. tuberculosis multirezistentu celmu prevalenci un salīdzināt fenotipiskās un genotipiskās multirezistences noteikšanas metodes. Metodes un materiāli: Diplomdarbā tika iekļauti dati par M. tuberculosis jutību pret da…
Normativitet: utfordring i psykoterapeutisk og pedagogisk arbeid. Den profesjonelle mellom tvang og frihet
2016
In this article we wish to discuss different normative dilemmas that teachers and psychotherapists meet in their work with the student and the patient. We argue that crucial for a good practice is not the actual choice between normativity and freedom, between generalized or authorized standards and individual dialogue. Rather it is the professional’s continuous reflection on the form and quality of the interactions with the pupil and the patient, and the preservation of the balance between personal ethos and professional responsibilities that best safeguard respect for the other's autonomy and self-determination. By illustrating psychotherapeutic malpractice and systematic mistreatment of c…