Search results for "Umana"

showing 10 items of 657 documents

Isolation and characterization of Oct-4+/HLA-G+ mesenchymal stem cells from human umbilical cord matrix: differentiation potential and detection of n…

2008

The presence of multipotent cells in several adult and embryo-related tissues opened new paths for their use in regenerative medicine. Extraembryonic tissues such as umbilical cord are considered a promising source of stem cells, potentially useful in therapy. The characterization of cells from the umbilical cord matrix (Wharton''s Jelly) and amniotic membrane revealed the presence of a population of mesenchymal-like cells, sharing a set of core-markers expressed by "mesenchymal stem cells". Several reports enlightened the differentiation capabilities of these cells, even if at times the lack of an extensive characterization of surface markers and immune co-stimulators expression revealed h…

HistologyCell Culture TechniquesClinical uses of mesenchymal stem cellsCell SeparationBiologyUmbilical CordHLA AntigensHumansAmnionMolecular BiologyCell ProliferationStem cell transplantation for articular cartilage repairHLA-G AntigensSettore BIO/16 - Anatomia UmanaMultipotent Stem CellsHistocompatibility Antigens Class IMesenchymal stem cellCell DifferentiationMesenchymal Stem CellsAmniotic stem cellsCell BiologyTelomereCord liningCell biologyMedical Laboratory TechnologyMesenchymal stem cells Umbilical cord matrix Differentiation protocols Tolerogenic properties Self-renewal markersAmniotic epithelial cellsImmunologyStem cellOctamer Transcription Factor-3BiomarkersAdult stem cellHistochemistry and Cell Biology

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Abstención sexual durante la Cuaresma en Andalucía a lo largo del siglo XX y su impacto en la estacionalidad de los nacimientos

2018

Durante siglos ha permanecido vigente en las poblaciones católicas un precepto religioso que prohibía las relaciones sexuales durante la Cuaresma. Esta interdicción repercutía en una disminución de concepciones y en un repunte tras dicho periodo, ambos difíciles de detectar porque, en poblaciones que no ejercían un control efectivo de la fecundidad, también se registraba un pico de concepciones durante la primavera. En la actualidad este precepto ha desaparecido como consecuencia de un proceso de erosión que no conocemos suficientemente. Con los datos anonimizados de todas las personas nacidas en Andalucía y supervivientes a 1 de enero de 2003 (n=8.397.206), este trabajo pretende determinar…

HistoryFecunditat humanamedia_common.quotation_subjectReligió i sociologiadifusiónFertilityHM401-1281preceptos religiosos060104 history03 medical and health sciences0302 clinical medicineSociology (General)0601 history and archaeologySexualitat Aspectes religiososconcepciónfecundidadmedia_common030219 obstetrics & reproductive medicineerosiónGeneral Social Sciences06 humanities and the artsInterdictionFecunditySexual intercoursePreceptHumanitiesRevista Internacional de Sociología

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Human HSP10 variants downregulation after cigarette smoke extract exposure in lung cells

2009

The impact of cigarette-smoke stress (a form of oxidative stress) on human lung fibroblasts and epithelial cells, particularly its effect on Hsp10 expression, has not been characterized despite the fact that a role for mitochondrial chaperonins in the development of lung diseases, ranging from chronic obstructive pulmonary disease to bronchial carcinogenesis, has been suggested (1). We studied the effects of non-lethal doses of cigarette smoke extract (CSE) on the expression of Hsp10 in human lung fibroblasts (HFL-1 line) and epithelial cells (16HBE line). Proteomics was carried out using 2D-IPG, silver stain, western blotting, and mass-spectrometry; mRNA was measured by RT-PCR. Database se…

Hsp10 cigarette smoke bronchial epithelial cells lung fibroblasts oxidative stress 2D-electrophoresis IPG isoelectric variants chaperoninsSettore BIO/16 - Anatomia Umana

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The reason for a project that was never performed: Alvar Aalto and the residential complex in Pavia (1966-68)

2015

This paper aims to analyze the characteristics of the project for the residential complex "Patrizia" in Pavia by Alvar Aalto (1966-1968). Although not realized, for political and economic reasons, the project offers an interesting example of urban planning in an “organic key”. In particular, this paper aims to contextualize the project of Aalto in the broader context of the residential building in Italy after World War II, when the problems of reconstruction and "home" are the heart of the debate on architecture. The project, in fact, takes place in the years immediately following the experiments of the social housing plan INA CASA (1949-63), which - with differences in design and architect…

Il presente contributo intende analizzare le caratteristiche del progetto di Alvar Aalto per il complesso residenziale “Patrizia” nella periferia S-O di Pavia ideato tra il 1966 e 1968. Sebbene non realizzato per motivazioni politico-economiche il progetto offre un interessante esempio di pianificazione urbana in chiave organica. Esso reinterpreta infatti le regole dell’insediamento storico pavese integrandosi nell’orografia della valle del fiume Ticino con un intervento a “scala umana” con una rete di percorsi pedonali verde attrezzato agricolo ed edifici ad anse regolari che seguono l’andamento delle curve di livello del luogo. In particolare questo contributo vuole contestualizzare il progetto di Aalto nel quadro più ampio dell’edilizia residenziale in Italia nel secondo dopoguerra quando il problema della ricostruzione e della “casa” sono il cuore del dibattito sull’architettura. Il progetto si colloca infatti negli anni immediatamente successivi alle sperimentazioni del piano sociale per l’edilizia pubblica INA CASA (1949-63) che con differenze progettuali e linguistiche variabili da regione a regione aveva comunque attinto molto dal neoempirismo scandinavo desumendo da quest’ultimo modelli insediativi tipologie edilizie e schemi distributivi interni alle abitazioni spesso però scadendo nel linguaggio vernacolare. Il quartiere “Patrizia” mostra rispetto agli esempi italiani un salto di qualità dovuto alla visione “organica” dell’architettura di Aalto e al suo approccio libero dai pregiudizi e dal “peso della storia” che gravava su tanti architetti italiani. Molti furono infatti gli oppositori al piano pavese che vedevano nel progetto di Aalto una minaccia per il centro storico di Pavia. Per analizzare il progetto ci si servirà quindi di due chiavi di lettura: una interna che ne descriverà le caratteristiche attraverso i disegni le relazioni scritte anche in rapporto ad altre opere del maestro finlandese e una esterna che contestualizzerà il progetto nel particolare momento storico italiano della ricostruzione post-bellica cercando anche di valutare gli apporti e l’influenza di Aalto sull’architettura italiana in particolare su alcuni protagonisti come Giancarlo De CarloSettore ICAR/18 - Storia Dell'Architettura

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Immune-related molecole are espresse by both naive and differentiated Wharton’s jelly mesenchymal stem cells: a new avenue for cellular therapy

2012

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Sex and race stereotypes in images of textbooks in primary physical education

2013

El objetivo de este trabajo es analizar las imágenes que aparecen en los libros de texto de Educación Física en el tercer ciclo de Educación Primaria y comprobar si los estereotipos con respecto al género y la raza han sido eliminados en sus contenidos. Se realiza un estudio descriptivo que utiliza el análisis de contenido como técnica central de la investigación. La muestra está formada por 997 imágenes, pertenecientes a cinco editoriales diferentes (Anaya, Inde, Paidotribo, Bruño y Serbal) que han publicado sus libros de texto a partir de la actual Ley de Educación 2/2006. Para el análisis de las imágenes, se utilizó el sistema de categorías elaborado por Táboas (2009), en un estudio simi…

ImágenesTextbooks5802.04 Niveles y Temas de EducaciónLibros de textoIl·lustració de llibresPhysical educationImagesRaza humanaEducació físicaEducación físicaHuman race

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Hsp10: Anatomic distribution, functions, and involvement in human disease

2013

There is growing evidence that molecular chaperones/heat shock proteins are involved in the pathogenesis of a number of human diseases, known as chaperonopathies. A better molecular understanding of the pathogenetic mechanisms is essential for addressing new strategies in diagnostics, therapeutics and clinical management of chaperonopathies, including those in which Hsp10 is involved. This chaperonin has been studied for a long time as a member of the mitochondrial protein-folding machine. However, although in normal cells Hsp10 is mainly localized in the mitochondrial matrix, it has also been found during and after stress in other subcellular compartments, such as cytosol, vesicles and sec…

InflammationAgingGeneral Immunology and MicrobiologySettore BIO/16 - Anatomia UmanaVesicleBiologyGeneral Biochemistry Genetics and Molecular BiologyChaperoninCell biologyAutoimmune DiseasesPathogenesisSettore MED/18 - Chirurgia GeneraleCytosolSettore MED/38 - Pediatria Generale E SpecialisticaBiochemistryMitochondrial matrixHeat shock proteinNeoplasmsCancer cellExtracellularChaperonin 10HumansHsp10chaperonopathies molecular chaperones human diseases cellular localization mitochondria

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Cigarette smoke promotes inflammasome‐independent activation of caspase‐1 and ‐4 leading to gasdermin D cleavage in human macrophages

2022

Mechanisms and consequences of gasdermin D (GSDMD) activation in cigarette smoke (CS)-associated inflammation and lung disease are unknown. GSDMD is a downstream effector of caspase-1, -8, and -4. Upon cleavage, GSDMD generates pores into cell membranes. Different degrees of GSDMD activation are associated with a range of physiological outputs ranging from cell hyperactivation to pyroptosis. We have previously reported that in human monocyte-derived macrophages CS extract (CSE) inhibits the NLRP3 inflammasome and shifts the response to lipopolysaccharide (LPS) towards the TLR4-TRIF axis leading to activation of caspase-8, which, in turn, activates caspase-1. In the present work, we investig…

InflammationLipopolysaccharidesPore Forming Cytotoxic Proteinsalveolar macrophages caspasecigarette smoke inflammasome lung Caspase 1 Caspases Caspases Initiator Humans Inflammation Intracellular Signaling Peptides and Proteins Lipopolysaccharides Lipopolysaccharides NLR Family Pyrin Domain-Containing 3 Protein Phosphate-Binding Proteins Pore Forming Cytotoxic Proteins Tobacco Cigarette Smoking Inflammasomes.InflammasomesSettore BIO/16 - Anatomia UmanaMacrophagesCaspase 1Intracellular Signaling Peptides and ProteinsPhosphate-Binding ProteinsBiochemistryCaspases InitiatorCigarette SmokingCaspasesNLR Family Pyrin Domain-Containing 3 ProteinTobaccoGeneticsHumansMolecular BiologyBiotechnologyThe FASEB Journal

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Data mining-based statistical analysis of biological data uncovers hidden significance: clustering Hashimoto’s thyroiditis patients based on the resp…

2014

The pathogenesis of Hashimoto's thyroiditis includes autoimmunity involving thyroid antigens, autoantibodies, and possibly cytokines. It is unclear what role plays Hsp60, but our recent data indicate that it may contribute to pathogenesis as an autoantigen. Its role in the induction of cytokine production, pro- or anti-inflammatory, was not elucidated, except that we found that peripheral blood mononucleated cells (PBMC) from patients or from healthy controls did not respond with cytokine production upon stimulation by Hsp60 in vitro with patterns that would differentiate patients from controls with statistical significance. This "negative” outcome appeared when the data were pooled and ana…

Interleukin 2Hashimoto’s thyroiditiShort Communicationmedicine.medical_treatmentStimulationHashimoto Diseasecomputer.software_genremedicine.disease_causeBiochemistryClusteringThyroiditisAutoimmunityInterferon-gammaCluster AnalysisData MiningHumansMedicineHashimoto DiseaseDelta valueIFN-γCells CulturedSettore BIO/16 - Anatomia Umanabusiness.industryIL-2ThyroidChaperonin 60Cell BiologyHsp60medicine.diseasemedicine.anatomical_structureCytokineClustering; Data mining; Delta values; Hashimoto’s thyroiditis; Hsp60; IFN-γ; IL-2ImmunologyLeukocytes MononuclearInterleukin-2Biomarker (medicine)Data miningbusinesscomputerAlgorithmsmedicine.drug

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Institut Valencià d'Infertilitat (IVI)

2006

Des de la seua creació en 1995 com a la primera institució mèdica d'Espanya especialitzada en la reproducció humana, l'Institut Valencià d' Infertilitat (IVI) ha esdevingut un referent per a professionals i pacients de tot el món. En 2004 es crea l'Institut Universitari IVI, adscrit a la Universitat de València. Els objectius d'aquest Institut són el desenvolupament de projectes d'investigació bàsica (Fundació IVI) i investigació clínica, la docència i la formació específica, en el camp de la Ciència de la

Investigació Medicina Reproducció humana IVI

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