Search results for "Umana"
showing 10 items of 657 documents
TGFbeta signaling: roles of Smads
2009
Extracellular vesicles in airway homeostasis and pathophysiology
2021
The epithelial–mesenchymal trophic unit (EMTU) is a morphofunctional entity involved in the maintenance of the homeostasis of airways as well as in the pathogenesis of several diseases, including asthma and chronic obstructive pulmonary disease (COPD). The “muco-microbiotic layer” (MML) is the innermost layer of airways made by microbiota elements (bacteria, viruses, archaea and fungi) and the surrounding mucous matrix. The MML homeostasis is also crucial for maintaining the healthy status of organs and its alteration is at the basis of airway disorders. Nanovesicles produced by EMTU and MML elements are probably the most important tool of communication among the different cell types, inclu…
Effects of essential oils and selected compounds from Lamiaceae family as adjutants on the treatment of subjects with periodontitis and cardiovascula…
2021
Essential oils from different plant species were found to contain different compounds exhibiting anti-inflammatory effects with the potential to be a valid alternative to conventional chemotherapy that is limited in long-term use due to its serious side effects. Generally, the first mechanism by which an organism counteracts injurious stimuli is inflammation, which is considered a part of the innate immune system. Periodontitis is an infectious and inflammatory disease caused by a dysbiosis in the subgingival microbiome that triggers an exacerbated immune response of the host. The immune–inflammatory component leads to the destruction of gingival and alveolar bone tissue. The main anti-infl…
Molecular profile study of extracellular vesicles for the identification of useful small “hit” in cancer diagnosis
2021
Tumor-secreted extracellular vesicles (EVs) are the main mediators of cell-cell communication, permitting cells to exchange proteins, lipids, and metabolites in varying physiological and pathological conditions. They contain signature tumor-derived molecules that reflect the intracellular status of their cell of origin. Recent studies have shown that tumor cell-derived EVs can aid in cancer metastasis through the modulation of the tumor microenvironment, suppression of the immune system, pre-metastatic niche formation, and subsequent metastasis. EVs can easily be isolated from a variety of biological fluids, and their content makes them useful biomarkers for the diagnosis, prognosis, monito…
L' escala global en la geografía humana
2001
La escala global en geografía humana se aplica en el siglo XIX a la manera imperialista por geógrafos como Ritter, Ratzel o Mackinder, mientras T. Malthus y M. Sorre la aplican considerando la Humanidad como una carga que ha de soportar el planeta. Los geógrafos del siglo XXI como Taylor y Harvey consideran la escala global humana de acuerdo con las divisiones del sistema político, de la economía y de los conflictos sociales. (A)
Utilización de microRNAs como dianas terapéuticas en Distrofia Miotónica
2018
La distrofia miotónica tipo 1 (DM1) se debe a una expansión del triplete CTG en 3´UTR del gen DMPK, mientras que, la distrofia miotónica tipo 2 (DM2) se origina por la de la repetición CCTG en el intrón 1 del gen CNBP. Son dos enfermedades multisistémicas con manifestaciones patológicas en músculo esquelético (miotonia, degeneración y debilidad muscular), corazón (defectos en la conducción cardiaca) y sistema nervioso central. Los transcritos DMPK y CNBP mutantes se pliegan en horquillas que secuestran factores de splicing alternativo, principalmente Muscleblind-like 1 (MBNL1; y su parálogo MBNL2). La falta de la proteínas MBNL origina problemas en el splicing de transcritos musculares y co…
Gobernanza territorial para el desarrollo sostenible : estado de la cuestión y agenda
2008
Joaquin.Farinos@uv.es La gobernanza territorial se ha convertido en el instrumento en el que se encuentran depositadas las esperanzas de una más efectiva gestión y gobierno de las políticas de desarrollo territorial. A lo largo del presente texto, en los sucesivos epígrafes, se analizan sus puntos fuertes y limitaciones; las estratégicas relaciones dialécticas –en ascendente sinergia– entre la gobernanza territorial, los objetivos de Lisboa y la cohesión territorial; porqué la planificación del desarrollo territorial sostenible es uno de los campos predilectos de aplicación de nuevas formas de gobernanza (entre ellos el Método Abierto de coordinación). Cierra el artículo una interpretación …
Highlights on two decades with microbiota and inflammatory bowel disease from etiology to therapy
2023
Inflammatory Bowel diseases (IBDs) constitute a complex panel of disorders characterized with chronic inflammation affecting the alimentary canal along with extra intestinal manifestations. Its exact etiology is still unknown; however, it seems to be the result of uncharacterized environmental insults in the intestine and their immunological consequences along with dysbiosis, in genetically predisposed individuals. It was the main target of our team since 2002 to explore the etiology of IBD and the related role of bacteria. For almost two decades, our laboratory, among others, has been involved in the reciprocal interaction between the host gastrointestinal lining and the homing microbiota.…
Exosomal Hsp60: A Tumor Biomarker?
2019
Exosomes (EXs) are extracellular vesicles containing proteins, DNA, mRNA, non-coding RNAs, such as miRNAs, and lipid. The EXs can be easily isolated from different biological fluids and their content is considered a potential biomarker in various diseases, such as cancer. EXs play an important role in intercellular communication, permitting cells to exchange proteins, lipids, and genetic material in normal and pathological conditions. New data have shown that tumor cells-derived EXs contribute to cancer progression through the modulation of tumor microenvironment. Heat shock proteins 60 kDa (Hsp60) is classically considered mitochondrial proteins with different biological roles. In recent y…
Lectotypification of the names of two species of Fumana ( Cistaceae )
2004
The names Cistus ericoides Cav. and C. laevis Cav. are typified. These names apply to two species, currently classified within the genus Fumana (Dunal) Spach, but the names have been frequently misapplied and both of thempose typification problems. The type specimen of the first has not been found. Thus an illustration is chosen as type and an epitype designated. The original material of C. laevis comprises a mixture of two different species. One element is selected to clarify the application of this binomial.