Search results for "United States"
showing 10 items of 383 documents
Cost-Effectiveness Analysis: Stress Ulcer Bleeding Prophylaxis with Proton Pump Inhibitors, H2 Receptor Antagonists
2012
Abstract Objectives Proton pump inhibitors (PPIs) and H2-receptor antagonists (H2RAs) present varying pharmacological efficacy in preventing stress ulcer bleeding (SUB) in intensive care units. The literature also reports disparate rates of ventilator-assisted pneumonia (VAP) as side effects of these treatments. We compared the cost-effectiveness of these two prophylactic pharmacological options. Methods We constructed a decision tree with a 60-day time horizon for patients at high risk for developing SUB, receiving either PPIs or H2RAs. For each treatment strategy, patients could be in one of three states of health: SUB, VAP, or no complication. Contemporary, clinically relevant probabilit…
Formulation predictive dissolution (fPD) testing to advance oral drug product development: an introduction to the US FDA funded ‘21st Century BA/BE’ …
2018
Over the past decade, formulation predictive dissolution (fPD) testing has gained increasing attention. Another mindset is pushed forward where scientists in our field are more confident to explore the in vivo behavior of an oral drug product by performing predictive in vitro dissolution studies. Similarly, there is an increasing interest in the application of modern computational fluid dynamics (CFD) frameworks and high-performance computing platforms to study the local processes underlying absorption within the gastrointestinal (GI) tract. In that way, CFD and computing platforms both can inform future PBPK-based in silico frameworks and determine the GI-motility-driven hydrodynamic impac…
Stany Zjednoczone w I wojnie światowej a odzyskanie niepodległości przez Polskę w 1918 roku w ujęciu współczesnej szkolnej narracji podręcznikowej
2018
Accotding to many historians, the US accession to the war in 1917 was of significant importance for the final resolution of the conflict, and thus also the revival of the independedt Polish state. In the article, we analyse this issue on the basic of contemporary Polish school history education. Textbooks for high school and technical school students were used as the source. Their authors agreed that "the entrance of Uncle Sam into the game", that is, the accession of the United States to the war in 1917 was one of the landmark moments in its over four - year history. The US president Thomas W. Wilson from January 8, 1918, in which a separate point about the revival of the independent Polis…
¿Estados Unidos de Europa? Mapeo y diseño de constituciones para Europa
2020
En los últimos tiempos, académicos, intelectuales públicos, movimientos políticos y sociales y destacados líderes políticos europeos de diferentes orientaciones ideológicas han hecho un llamamiento a la creación de unos Estados Unidos de Europa. Desde su punto de vista, enfrentar la crisis de legitimidad de la UE requiere una renovación democrática a través de un proceso constituyente. Sin embargo, estas declaraciones no han sido acompañadas por un diseño específico sobre cómo instituir esta nueva Constitución Europea. Con el objeto de discutir las posibles vías de poner en práctica esta idea, este artículo presenta las principales formulaciones del poder constituyente europeo y su traducci…
The impact of COVID-19 on the practice of Oral and Maxillofacial Pathology in the United States and Canada.
2022
The COVID-19 pandemic has significantly disrupted the delivery of healthcare, including oral healthcare services. The restrictions imposed for mitigating spread of the virus forced dental practitioners to adopt significant changes in their workflow pattern. The aim of this study was to investigate the impact of the pandemic on the practice of oral and maxillofacial pathology in two countries in regard to educational activities, and clinical and diagnostic pathology services.An online questionnaire was distributed to oral and maxillofacial pathologists in the United States and Canada. The survey was designed by combining dichotomous, multiple choice, and Likert response scale questions. Stat…
Latent structure of the Centre for Epidemiologic Studies Depression Scale (CES-D) in older adult populations: a systematic review
2019
Objective: The Center for Epidemiologic Studies Depression Scale (CES-D) is a 20-item, self-report metric intended to measure depression. Despite being one of the most popular depression scales, the psychometric properties, specifically the underlying factor structure of the scale, have come under scrutiny. The latent structure of a scale is a key indicator of its construct validity, i.e. the degree to which the intended variable is captured. To date, a comprehensive review of the latent structure of the CES-D in older adult populations (≥65 years old) has not been conducted. We aimed to examine the latent structure of the CES-D in samples of older adults to assess its ability to capture de…
Research trends in the journal Hormones and Behavior (1987-2000).
2003
As a continuation of the study carried out by Svare more than 15 years ago (Horm. Behav. 22 (1988), 139) and to determine the tendencies of the evolution of behavioral endocrinology since then, our aim was to extend his work until 2000, assuming that the journal Hormones and Behavior would be representative of the field at large. To study this 14-year period and compare it with Svare's data, we kept the same criteria and categories, behavioral patterns, and species. Our results show that "sexual behavior" in "rodents" is still the most extensive field studied by behavioral endocrinologists, although frequency of other topics is increasing, above all "aggressive and emotional responses," and…
Initial experiences in radiology e-learning
2007
The use of two different educator-centric learning management systems (LMSs), Moodle and Manila, for radiology e-learning was formatively evaluated and the implications of the future use of LMSs in radiology education were explored. NeuroRAD, a neuroradiologic digital library and learning community, is implemented with Moodle, one of the most popular open-source educator-centric LMSs. Pediatric-Education.org, a pediatric digital library and learning community, is implemented with Manila, a commercial educator-centric LMS. Quantitative and qualitative analyses of these LMSs were performed with World Wide Web server log file statistical programs and user-submitted comment forms. In 2005, Neur…
Knowledge Gaps and Research Priorities in Immune Checkpoint Inhibitor–related Pneumonitis. An Official American Thoracic Society Research Statement
2019
Rationale: Immune checkpoint inhibitors (ICIs) have revolutionized cancer care but are associated with unique adverse events, including potentially life-threatening pneumonitis. The diagnosis of ICI-pneumonitis is increasing; however, the biological mechanisms, clinical and radiologic features, and the diagnosis and management have not been well defined. Objectives: To summarize evidence, identify knowledge and research gaps, and prioritize topics and propose methods for future research on ICI-pneumonitis. Methods: A multidisciplinary group of international clinical researchers reviewed available data on ICI-pneumonitis to develop and refine research questions pertaining to ICI-pneumonitis.…
An Official American Thoracic Society Workshop Report: Evaluation and Management of Asthma in the Elderly.
2016
Asthma in the elderly (>65 yr old) is common and associated with higher morbidity and mortality than asthma in younger patients. The poor outcomes in this group are due, in part, to underdiagnosis and undertreatment. There are a variety of factors related to aging itself that affect the presentation of asthma in the elderly and influence diagnosis and management. Structural changes in the aging lung superimposed on structural changes due to asthma itself can worsen the disease and physiologic function. Changes in the aging immune system influence the cellular composition and function in asthmatic airways. These processes and differences from younger individuals with asthma are not well u…